{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T08:41:47Z","timestamp":1768639307516,"version":"3.49.0"},"reference-count":103,"publisher":"Informa UK Limited","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders"],"published-print":{"date-parts":[[2004,1]]},"DOI":"10.1080\/14660820410020187","type":"journal-article","created":{"date-parts":[[2004,6,7]],"date-time":"2004-06-07T15:41:35Z","timestamp":1086622895000},"page":"84-98","source":"Crossref","is-referenced-by-count":44,"title":["Amyotrophic lateral sclerosis: a consensus viewpoint on designing and implementing a clinical trial"],"prefix":"10.1080","volume":"5","author":[{"given":"P Nigel","family":"Leigh","sequence":"first","affiliation":[]},{"given":"Michael","family":"Swash","sequence":"additional","affiliation":[]},{"given":"Yasuo","family":"Iwasaki","sequence":"additional","affiliation":[]},{"given":"Albert","family":"Ludolph","sequence":"additional","affiliation":[]},{"given":"Vincent","family":"Meininger","sequence":"additional","affiliation":[]},{"given":"Robert G","family":"Miller","sequence":"additional","affiliation":[]},{"given":"Hiroshi","family":"Mitsumoto","sequence":"additional","affiliation":[]},{"given":"Pamela","family":"Shaw","sequence":"additional","affiliation":[]},{"given":"Kunio","family":"Tashiro","sequence":"additional","affiliation":[]},{"given":"Leonard","family":"Van Den Berg","sequence":"additional","affiliation":[]}],"member":"301","published-online":{"date-parts":[[2009,7,10]]},"reference":[{"key":"CIT0001","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1046\/j.1365-2990.1998.00108.x","volume":"24","author":"Ince PG","year":"1998","journal-title":"Neuropathol Appl Neurobiol"},{"key":"CIT0002","first-page":"24","volume-title":"Bull de la Societe Med des Hopit de Paris","author":"Charcot JM.","year":"1865"},{"key":"CIT0003","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1001\/archneur.1972.00490170029005","volume":"27","author":"Olivares L","year":"1972","journal-title":"Arch Neurol"},{"key":"CIT0004","first-page":"231","volume":"55","author":"Rosati G","year":"1977","journal-title":"Studies on epidemiological, clinical and aetiological aspects of ALS disease in Sardinia, southern Italy. Acta Neurol Scand"},{"issue":"24","key":"CIT0005","first-page":"1","volume":"42","author":"Brewis M","year":"1966","journal-title":"Acta Neurol Scand"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000048208.54755.78"},{"key":"CIT0008","first-page":"1025","volume":"53","author":"Preux PM","year":"2000","journal-title":"Estimation of the amyotrophic lateral sclerosis incidence by capture-recapture method in the Limousin region of France. J Clin Epidemiol"},{"key":"CIT0011","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1212\/WNL.52.3.504","volume":"52","author":"Traynor BJ","year":"1999","journal-title":"Neurology"},{"key":"CIT0012","doi-asserted-by":"crossref","unstructured":"Kondo K. Epidemiology of motor neuron disease. In: PN Leigh, M Swash, eds. Motor Neuron Disease: Biology and Manage- ment. Springer-Verlag, 1995: 19.","DOI":"10.1007\/978-1-4471-1871-8_2"},{"key":"CIT0013","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0022-510X(01)00630-X","volume":"191","author":"Worms PM.","year":"2001","journal-title":"J Neurol Sci"},{"key":"CIT0014","first-page":"355","volume":"4","author":"Kurland LT","year":"1954","journal-title":"Preliminary report on geogra- phical distribution, with special reference to the Mariana Islands, including clinical and pathological observations. Neurology"},{"key":"CIT0015","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1093\/oxfordjournals.aje.a114437","volume":"124","author":"Plato CC","year":"1986","journal-title":"Am J Epidemiol"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.30.5.463"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.6.768"},{"key":"CIT0018","first-page":"6","volume":"39","author":"Pavlovsky Z","year":"2003","journal-title":"Cesk Patol"},{"key":"CIT0020","first-page":"358","volume":"10","author":"Dupuis L","year":"2002","journal-title":"Nogo provides a molecular marker for diagnosis of amyotrophic lateral sclerosis. Neurobiol Dis"},{"key":"CIT0021","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/00127893-199903000-00002","volume":"5","author":"Bromberg M.","year":"1999","journal-title":"Neurologist"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1080\/146608200300079536"},{"key":"CIT0023","doi-asserted-by":"crossref","unstructured":"Chaudhuri KR, Crump S, al-Sarraj S, Anderson V, Cavanagh J, Leigh PN. The validation of El Escorial criteria for the diagnosis of amyotrophic lateral sclerosis: a clinicopathological study. J Neurol Sci 1995; 129(Suppl): 11\u201312.","DOI":"10.1016\/0022-510X(95)00050-C"},{"key":"CIT0024","doi-asserted-by":"crossref","unstructured":"Turner MR, Bakker M, Sham P, Shaw CE, Leigh PN, Al-Chalabi C. Prognostic modelling of therapeutic interventions in amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord 2002; 3: 15\u201321.","DOI":"10.1080\/146608202317576499"},{"key":"CIT0025","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0022-510X(00)00418-4","volume":"180","author":"Househam E","year":"2000","journal-title":"J Neurol Sci"},{"key":"CIT0026","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1001\/archneur.55.4.526","volume":"55","author":"Riviere M","year":"1998","journal-title":"Arch Neurol"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-200008000-00006"},{"key":"CIT0028","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1056\/NEJM200105313442207","volume":"344","author":"Rowland LP","year":"2001","journal-title":"N Engl J Med"},{"key":"CIT0029","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s11910-001-0078-7","volume":"1","author":"Shaw CE","year":"2001","journal-title":"Curr Neurol Neurosci Rep"},{"key":"CIT0030","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/35097565","volume":"2","author":"Cleveland DW","year":"2001","journal-title":"Nat Rev Neurosci"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9084(02)00025-1"},{"key":"CIT0032","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0022-510X(00)00422-6","volume":"180","author":"Julien JP","year":"2000","journal-title":"J Neurol Sci"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199905000-00005"},{"key":"CIT0034","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1046\/j.0305-1846.2001.00332.x","volume":"27","author":"Sathasivam S","year":"2001","journal-title":"Neuropathol Appl Neurobiol"},{"key":"CIT0035","first-page":"59","volume":"362","author":"Rosen DR","year":"1993","journal-title":"Mutations in Cu\/Zn superoxide dismutase gene are associated with familial amyo- trophic lateral sclerosis. Nature"},{"key":"CIT0036","first-page":"390","volume":"43","author":"Shaw CE","year":"1998","journal-title":"Mutations in all five exons of SOD-1 may cause ALS. Ann Neurol"},{"key":"CIT0037","first-page":"160","volume":"29","author":"Yang Y","year":"2001","journal-title":"The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains is mutated in a form of recessive amyotrophic lateral sclerosis. Nat Genet"},{"key":"CIT0038","first-page":"715","volume":"34","author":"LaMonte BH","year":"2002","journal-title":"Disruption of dynein\/ dynactin inhibits axonal transport in motor neurons causing late- onset progressive degeneration. Neuron"},{"key":"CIT0039","first-page":"455","volume":"33","author":"Puls I","year":"2003","journal-title":"Mutant dynactin in motor neuron disease. Nat Genet"},{"key":"CIT0040","first-page":"157","volume":"8","author":"Al-Chalabi A","year":"1999","journal-title":"Deletions of the heavy neurofilament subunit tail in amyotrophic lateral sclerosis. Hum Mol Genet"},{"key":"CIT0041","first-page":"939","volume":"160","author":"Robertson J","year":"2003","journal-title":"A neurotoxic peripherin slice variant in a mouse model of ALS. J Cell Biol"},{"key":"CIT0042","first-page":"1348","volume":"60","author":"Meyer T","year":"2003","journal-title":"High rate of constitutional chromosomal rearrangements in apparently sporadic ALS. Neurology"},{"key":"CIT0043","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1056\/NEJMra022366","volume":"348","author":"Friedlander RM.","year":"2003","journal-title":"New Engl J Med"},{"key":"CIT0044","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1385\/NMM:3:2:65","volume":"3","author":"Mattson M.","year":"2003","journal-title":"Neuromolecular Med"},{"key":"CIT0045","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1172\/JCI200317610","volume":"111","author":"Guegan C","year":"2003","journal-title":"J Clin Invest"},{"key":"CIT0047","first-page":"455","volume":"7","author":"Martin LJ.","year":"2001","journal-title":"Int J Mol Med"},{"key":"CIT0048","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/nrn1100","volume":"4","author":"Vila M","year":"2003","journal-title":"Nat Rev Neurosci"},{"key":"CIT0049","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1002\/mus.10186","volume":"26","author":"Heath AM","year":"2002","journal-title":"Muscle Nerve"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(02)00357-X"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-5846(03)00025-3"},{"key":"CIT0052","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1001\/archneur.57.12.1695","volume":"57","author":"Deng H-X Siddique T.","year":"2000","journal-title":"Arch Neurol"},{"key":"CIT0053","first-page":"147","volume":"39","author":"Gurney ME","year":"1996","journal-title":"Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis. Ann Neurol"},{"key":"CIT0054","first-page":"347","volume":"5","author":"Klivenyi P","year":"1999","journal-title":"Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis. Nat Med"},{"key":"CIT0055","first-page":"9","volume":"2","author":"Desnuelle C","year":"2001","journal-title":"A double-blind, placebo controlled randomised clinical trial of alpha- tocopherol (vitamin E) in the treatment of amyotrophic lateral sclerosis. ALS Riluzole-tocopherol Study Group. Amyotroph Lat Scler Other Motor Neuron Disord"},{"key":"CIT0056","first-page":"843","volume":"56","author":"Miller RG","year":"2001","journal-title":"Phase III randomised trial of gabapentin in patients with amyotrophic lateral sclerosis. Neurology"},{"key":"CIT0057","first-page":"437","volume":"53","author":"Groeneveld GJ","year":"2003","journal-title":"A randomised sequential trial of creatine in amyotrophic lateral sclerosis. Ann Neurol"},{"key":"CIT0058","first-page":"82","volume":"21","author":"Shibata N.","year":"2001","journal-title":"Neuro- pathol"},{"key":"CIT0059","first-page":"1621","volume":"49","author":"Lai EC","year":"1997","journal-title":"Effect of recombinant human insulin-like growth factor-I on progression of ALS. A placebo controlled study. The North America ALS\/IGF-I Study Group. Neurology"},{"key":"CIT0060","first-page":"583","volume":"51","author":"Borasio GD","year":"1998","journal-title":"A placebo controlled trial of insulin-like growth factor-I in amyotrophic lateral sclerosis. European ALS\/IGF-I Study Group. Neurology"},{"key":"CIT0061","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1212\/WNL.52.7.1427","volume":"52","author":"Study Group BDNF","year":"1999","journal-title":"Neurology"},{"key":"CIT0062","first-page":"1244","volume":"46","author":"Treatment Study ALS CNTF","year":"1996","journal-title":"A double-blind placebo controlled clinical trial of subcutaneous recombinant human ciliary neurotrophic factor (rHCNTF) in amyotrophic lateral sclerosis. ALS CNTF Treatment Study Group. Neurology"},{"key":"CIT0063","first-page":"1329","volume":"47","author":"Miller RG","year":"1996","journal-title":"Toxicity and tolerability of recombinant human ciliary neurotrophic factor in patients with amyotrophic lateral sclerosis. Neurology"},{"key":"CIT0064","first-page":"1383","volume":"47","author":"Miller RG","year":"1996","journal-title":"Placebo-controlled trial of gabapentin in patients with amyotrophic lateral sclerosis. Western Amyotrophic Lateral Sclerosis Study Group. Neurology"},{"key":"CIT0065","first-page":"585","volume":"330","author":"Bensimon G","year":"1994","journal-title":"ALS\/Riluzole Study Group [see comments]. N Engl J Med"},{"key":"CIT0066","first-page":"1425","volume":"347","author":"Lacomblez L","year":"1996","journal-title":"Amyotrophic Lateral Sclerosis\/Riluzole Study Group II [see comments]. Lancet"},{"key":"CIT0069","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1080\/146608202317576534","volume":"3","author":"Drory VE","year":"2002","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disord"},{"key":"CIT0070","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/sj.sc.3101281","volume":"40","author":"Savas S","year":"2002","journal-title":"Spinal Cord"},{"key":"CIT0072","first-page":"74","volume":"417","author":"Zhu S","year":"2002","journal-title":"Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice. Nature"},{"key":"CIT0073","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1006\/nbdi.2002.0487","volume":"10","author":"Kriz J","year":"2002","journal-title":"Neurobiol Dis"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200206120-00018"},{"key":"CIT0075","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0028-3908(99)00019-2","volume":"386","author":"Parsons CG","year":"1999","journal-title":"Neuropharmacology"},{"key":"CIT0076","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1517\/13543784.9.6.1397","volume":"9","author":"Jain KK.","year":"2000","journal-title":"Expert Opin Investig Drugs"},{"key":"CIT0077","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1161\/01.STR.32.5.1220","volume":"32","author":"Lapchak PA","year":"2001","journal-title":"Stroke"},{"key":"CIT0078","first-page":"721","volume":"131","author":"Sagot Y","year":"2000","journal-title":"An orally active anti-apoptotic molecule (CGP 3466B) preserves mitochondria and enhances survival in an animal model of motor neuron disease. Br J Pharmacol"},{"key":"CIT0079","first-page":"2040","volume":"57","author":"Bourke SC","year":"2001","journal-title":"sleep- disordered breathing as predictors of QOL in ALS. Neurology"},{"key":"CIT0080","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1080\/146608202317576480","volume":"3","author":"Lechtzin N","year":"2002","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disord"},{"key":"CIT0081","first-page":"75","volume":"191","author":"Jackson CE","year":"2001","journal-title":"A preliminary evaluation of a prospective study of pulmonary function studies and symptoms of hypoventilation in ALS\/MND patients. J Neurol Sci"},{"key":"CIT0082","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1212\/01.WNL.0000042781.22278.0A","volume":"60","author":"Lou JS","year":"2003","journal-title":"Neurology"},{"key":"CIT0083","first-page":"482","volume":"71","author":"Newsom-Davis IC","year":"2001","journal-title":"Leigh PN et al. The effect of non- invasive positive pressure ventilation (NIPPV) on cognitive function in amyotrophic lateral sclerosis (ALS): a prospective study. J Neurol Neurosurg Psychiatry"},{"key":"CIT0084","first-page":"153","volume":"57","author":"Lyall RA","year":"2001","journal-title":"A prospective study of quality of life in ALS patients treated with non-invasive ventilation. Neurology"},{"key":"CIT0085","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1093\/brain\/124.10.2000","volume":"124","author":"Lyall RA","year":"2001","journal-title":"Brain"},{"issue":"4","key":"CIT0087","doi-asserted-by":"crossref","first-page":"S233","DOI":"10.1212\/WNL.47.6_Suppl_4.233S","volume":"47","author":"Doble A.","year":"1996","journal-title":"Neurology"},{"key":"CIT0088","first-page":"152","volume":"36","author":"Mitsumoto H","year":"1986","journal-title":"Negroski D et al. Amyotrophic lateral sclerosis: effects of acute intravenous and chronic subcutaneous administration of thyrotropin-releasing hormone in controlled trials. Neurology"},{"key":"CIT0089","first-page":"537","volume":"43","author":"Abe K","year":"2001","journal-title":"Decrease in N- acetylaspartate\/creatine ratio in the motor area and the frontal lobe in amyotrophic lateral sclerosis. Neuroradiology"},{"key":"CIT0090","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0022-510X(03)00024-8","volume":"210","author":"de Carvalho M","year":"2003","journal-title":"J Neurol Sci"},{"key":"CIT0091","first-page":"33","volume":"88","author":"Shefner JM","year":"2002","journal-title":"Adv Neurol"},{"issue":"1","key":"CIT0092","doi-asserted-by":"crossref","first-page":"S91","DOI":"10.1080\/146608202320374417","volume":"3","author":"Olney RK.","year":"2002","journal-title":"Amyotroph Lat Scler"},{"key":"CIT0093","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1016\/S1388-2457(01)00692-7","volume":"112","author":"Eisen A","year":"2001","journal-title":"Clin Neurophysiol"},{"key":"CIT0095","volume-title":"Moore DH. ALSFRS-R as a primary outcome measure in amyotrophic lateral sclerosis clinical trials","author":"Gordon H","year":"2003"},{"key":"CIT0096","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1002\/mus.10090","volume":"25","author":"Magnus T","year":"2002","journal-title":"Muscle Nerve"},{"key":"CIT0099","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410220308"},{"key":"CIT00100","first-page":"274","volume":"48","author":"Sanjak M","year":"2000","journal-title":"Prospective quality control of vital capacity as primary endpoint in international multicentre therapeutic trial of SR57746A (xaliproden) in amyotrophic lateral sclerosis. Ann Neurol"},{"key":"CIT00101","first-page":"225","volume-title":"Handbook of Neurologic Rating Scales. Demos Vermande","author":"Coulthard-Morris L","year":"1997"},{"issue":"1","key":"CIT00102","first-page":"S18","volume":"152","author":"McGuire D","year":"1997","journal-title":"A brief quality- of-life measure for ALS clinical trials based on a subset of items from the Sickness Impact Profile. The Syntex-Synergen ALS\/CNTF Study Group. J Neurol Sci"},{"key":"CIT00103","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1191\/0269215503cr624oa","volume":"17","author":"Jenkinson C","year":"2003","journal-title":"Clin Rehabil"},{"key":"CIT00105","first-page":"31","volume":"2","author":"Bromberg MB","year":"2001","journal-title":"ALS CARE Study Group. Clinical Assessment, Research, and Education. Amyotroph Lateral Scler Other Motor Neuron Disord"},{"key":"CIT00106","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1007\/s004150070069","volume":"247","author":"Jenkinson C","year":"2000","journal-title":"J Neurol"},{"key":"CIT00107","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1212\/WNL.56.4.442","volume":"56","author":"Robbins RA","year":"2001","journal-title":"Neurology"},{"key":"CIT00108","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1212\/WNL.24.8.721","volume":"24","author":"Jr Norris FH","year":"1974","journal-title":"Neurology"},{"key":"CIT00109","first-page":"13","volume":"169","author":"Cedarbaum JM","year":"1999","journal-title":"Malta E et al. The ALSFRS-R: a revised ALS functional rating scale that incorporates assess- ments of respiratory function. BDNF ALS Study Group (Phase III). J Neurol Sci"},{"key":"CIT00111","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1097\/00005650-198108000-00001","volume":"19","author":"Bergner M","year":"1981","journal-title":"Med Care"},{"issue":"3","key":"CIT00112","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/BF03161085","volume":"246","author":"Jenkinson C","year":"1999","journal-title":"J Neurol"},{"key":"CIT00113","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1136\/jnnp.70.1.70","volume":"70","author":"Jenkinson C","year":"2001","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"CIT00114","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1136\/bmj.313.7048.29","volume":"313","author":"Hickey AM","year":"1996","journal-title":"BMJ"},{"issue":"1","key":"CIT00115","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1080\/14660820152415690","volume":"2","author":"Munsat TL.","year":"2001","journal-title":"Amyo- troph Lateral Scler Other Motor Neuron Disord"},{"key":"CIT00116","first-page":"20","volume":"2","author":"Moore DH","year":"2001","journal-title":"Improving efficiency of ALS Clinical Trials. (12th International Symposium on ALS\/MND). Amyotroph Lateral Scler Other Motor Neuron Disord"},{"key":"CIT00117","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S0022-510X(99)00209-9","volume":"169","author":"Miller RG","year":"1999","journal-title":"J Neurol Sci"}],"container-title":["Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/14660820410020187","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,5,28]],"date-time":"2018-05-28T17:55:22Z","timestamp":1527530122000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14660820410020187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1]]},"references-count":103,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2009,7,10]]},"published-print":{"date-parts":[[2004,1]]}},"alternative-id":["10.1080\/14660820410020187"],"URL":"https:\/\/doi.org\/10.1080\/14660820410020187","relation":{},"ISSN":["1466-0822"],"issn-type":[{"value":"1466-0822","type":"print"}],"subject":[],"published":{"date-parts":[[2004,1]]}}}