{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T08:52:50Z","timestamp":1775206370927,"version":"3.50.1"},"reference-count":255,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2022,1,2]],"date-time":"2022-01-02T00:00:00Z","timestamp":1641081600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","award":["404067\/2012-3 and 2020\/00433-8"],"award-info":[{"award-number":["404067\/2012-3 and 2020\/00433-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001713","name":"European and Developing Countries Clinical Trials Partnership","doi-asserted-by":"crossref","award":["RIA2017T-2018"],"award-info":[{"award-number":["RIA2017T-2018"]}],"id":[{"id":"10.13039\/501100001713","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Funda\u00e7\u00e3o de Amparo *a Pesquisa do Estado de mInas Gerais","award":["CBB-APQ 00952-16"],"award-info":[{"award-number":["CBB-APQ 00952-16"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Drug Metabolism &amp; Toxicology"],"published-print":{"date-parts":[[2022,1,2]]},"DOI":"10.1080\/17425255.2022.2049235","type":"journal-article","created":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T10:40:28Z","timestamp":1647254428000},"page":"39-59","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":15,"title":["An update on pharmacogenetic factors influencing the metabolism and toxicity of artemisinin-based combination therapy in the treatment of malaria"],"prefix":"10.1080","volume":"18","author":[{"given":"Leyre","family":"Pernaute-Lau","sequence":"first","affiliation":[{"name":"Department of Microbiology, Tumor and Cell biology, Karolinska Institutet, Solna, Sweden"},{"name":"Faculty of Sciences, BioISI - Biosystems & Integrative Sciences Institute, University of Lisbon, Lisbon, 1749-016, Portugal"}]},{"given":"Mahamadou","family":"Camara","sequence":"additional","affiliation":[{"name":"Department of Epidemiology of Parasitic Diseases, Faculty of Pharmacy, Malaria Research and Training Center, University of Science, Techniques and Technologies of Bamako, Bamako, Mali"}]},{"given":"Ta\u00eds","family":"N\u00f3brega de Sousa","sequence":"additional","affiliation":[{"name":"Molecular Biology and Malaria Immunology Research Group, Instituto Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz (FIOCRUZ), Belo Horizonte, Brasil"}]},{"given":"Ulrika","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Tumor and Cell biology, Karolinska Institutet, Solna, Sweden"}]},{"given":"Marcelo Urbano","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Faculty of Sciences, BioISI - Biosystems & Integrative Sciences Institute, University of Lisbon, Lisbon, 1749-016, Portugal"},{"name":"Department of Parasitology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}]},{"given":"Jos\u00e9 Pedro","family":"Gil","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Tumor and Cell biology, Karolinska Institutet, Solna, Sweden"},{"name":"Faculty of Sciences, BioISI - Biosystems & Integrative Sciences Institute, University of Lisbon, Lisbon, 1749-016, Portugal"},{"name":"Global Health and Tropical Medicine, Institute of Hygiene and Tropical Medicine, Nova University of Lisbon, Portugal"}]}],"member":"301","published-online":{"date-parts":[[2022,4,4]]},"reference":[{"key":"cit0001","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2011.608660"},{"key":"cit0002","unstructured":"MMV-supported projects [Internet]. Geneva: Medicines for Malaria Venture; [cited 2021 Jun 08]. Available from: https:\/\/www.mmv.org\/research-development\/mmv-supported-projects"},{"key":"cit0003","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16767-6"},{"key":"cit0004","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00487-9"},{"key":"cit0005","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-10-281"},{"key":"cit0006","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-10-349"},{"key":"cit0007","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-021-03620-6"},{"key":"cit0008","unstructured":"World Health Organization. World Malaria Report. 2020."},{"key":"cit0009","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-017-0940-3"},{"issue":"12","key":"cit0010","first-page":"1378","volume":"78","author":"Bloland PB","year":"2000","journal-title":"Bull World Health Organ"},{"key":"cit0011","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2020.12.011"},{"key":"cit0012","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4922(01)02085-2"},{"key":"cit0013","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200847020-00002"},{"key":"cit0014","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200262090-00003"},{"key":"cit0015","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.12.2943"},{"key":"cit0016","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30409-1"},{"key":"cit0017","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30415-7"},{"key":"cit0018","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2005.09.001"},{"key":"cit0019","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2007.77.1034"},{"key":"cit0020","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911317106"},{"key":"cit0021","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.04181-14"},{"key":"cit0022","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-017-1712-4"},{"key":"cit0023","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01949-20"},{"key":"cit0024","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)61510-3"},{"key":"cit0025","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2018.1524871"},{"key":"cit0026","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmaid.2020.101765"},{"key":"cit0027","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S265602"},{"key":"cit0028","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-018-1045-3"},{"key":"cit0029","doi-asserted-by":"publisher","DOI":"10.1186\/s40249-016-0196-8"},{"key":"cit0030","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2016.1192462"},{"key":"cit0031","doi-asserted-by":"publisher","DOI":"10.4155\/fmc-2019-0225"},{"key":"cit0032","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00318-7"},{"key":"cit0033","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2019.08.030"},{"issue":"3","key":"cit0034","first-page":"380","volume":"22","author":"Bunnag D","year":"1991","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"cit0035","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0805011"},{"key":"cit0036","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808859"},{"key":"cit0037","doi-asserted-by":"publisher","DOI":"10.1086\/657402"},{"key":"cit0038","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1999.00044.x"},{"key":"cit0039","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-003-0636-9"},{"key":"cit0040","doi-asserted-by":"publisher","DOI":"10.3109\/15376516.2011.623331"},{"key":"cit0041","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.13-0531"},{"key":"cit0042","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.30.9.1005"},{"key":"cit0043","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2001.65.717"},{"key":"cit0044","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1996.tb01151.x"},{"key":"cit0045","doi-asserted-by":"publisher","DOI":"10.3109\/03602530903491741"},{"key":"cit0046","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00275-21"},{"key":"cit0047","unstructured":"World Health Organization. Drug Policies by Region [Internet]. Geneva: World Health Organization; [cited 2021 May 08]. Available from: https:\/\/www.who.int\/malaria\/am_drug_policies_by_region_afro\/en\/"},{"key":"cit0048","doi-asserted-by":"publisher","DOI":"10.1007\/s002280050648"},{"key":"cit0049","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2002.01696.x"},{"key":"cit0050","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01700-12"},{"key":"cit0051","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30552-3"},{"issue":"1","key":"cit0052","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/s12936-020-03287-5","volume":"19","author":"Mhamilawa LE","year":"2020","journal-title":"Malar J"},{"key":"cit0053","doi-asserted-by":"publisher","DOI":"10.1124\/mol.104.009019"},{"key":"cit0054","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-13-214"},{"key":"cit0055","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.107.016600"},{"key":"cit0056","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0b013e318274197e"},{"key":"cit0057","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1987.tb03079.x"},{"key":"cit0058","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199019040-00002"},{"issue":"2","key":"cit0059","first-page":"207","volume":"69","author":"Karbwang J","year":"1991","journal-title":"Bull World Health Organ"},{"issue":"1","key":"cit0060","first-page":"83","volume":"72","author":"Karbwang J","year":"1994","journal-title":"Bull World Health Organ"},{"key":"cit0061","doi-asserted-by":"publisher","DOI":"10.1007\/s002280050008"},{"key":"cit0062","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm355"},{"key":"cit0063","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-8-58"},{"key":"cit0064","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01187-09"},{"key":"cit0065","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku154"},{"key":"cit0066","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-018-2416-0"},{"key":"cit0067","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(00)00546-4"},{"key":"cit0068","doi-asserted-by":"publisher","DOI":"10.1211\/0022357001777243"},{"key":"cit0069","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2710.2005.00651.x"},{"key":"cit0070","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200007000-00001"},{"key":"cit0071","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.120.000261"},{"key":"cit0072","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-1758"},{"key":"cit0073","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2005.11.015"},{"key":"cit0074","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/90.16.1225"},{"key":"cit0075","doi-asserted-by":"publisher","DOI":"10.1002\/em.10199"},{"key":"cit0076","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0b013e31815e93c6"},{"key":"cit0077","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2003.091"},{"key":"cit0078","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-11-111"},{"key":"cit0079","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(02)00066-2"},{"key":"cit0080","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4165(00)00160-4"},{"key":"cit0081","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2006.07.003"},{"key":"cit0082","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2005.05.022"},{"key":"cit0083","doi-asserted-by":"publisher","DOI":"10.1081\/DMR-200047984"},{"key":"cit0084","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.04140-14"},{"key":"cit0085","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.06009-11"},{"key":"cit0086","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2015.37"},{"key":"cit0087","doi-asserted-by":"publisher","DOI":"10.1586\/eri.12.51"},{"key":"cit0088","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-8-S1-S4"},{"issue":"4","key":"cit0089","first-page":"434","volume":"15","author":"Borrmann S","year":"2010","journal-title":"Trop Med Int Health"},{"key":"cit0090","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2006.01739.x"},{"key":"cit0091","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2008.05.022"},{"key":"cit0092","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-016-1327-1"},{"key":"cit0093","doi-asserted-by":"publisher","DOI":"10.2217\/pgs-2017-0032"},{"key":"cit0094","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.7.2106-2109.2001"},{"key":"cit0095","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05136-11"},{"key":"cit0096","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-006-0199-7"},{"key":"cit0097","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-007-0861-9"},{"key":"cit0098","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-008-1080-8"},{"key":"cit0099","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01312-10"},{"key":"cit0100","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02595-14"},{"key":"cit0101","unstructured":"Hansson HH Human Genetic Variation and their potential role in drug metabolism and susceptibility to malaria [dissertation]. University of Copenhagen; 2015. https:\/\/scholar.google.com\/citations?view_op=view_citation&hl=da&user=An7bNBIAAAAJ&citation_for_view=An7bNBIAAAAJ:UeHWp8X0CEIC (accessed, 2021 Nov, 2)."},{"key":"cit0102","doi-asserted-by":"publisher","DOI":"10.2131\/jts.38.349"},{"key":"cit0103","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2010.28"},{"key":"cit0104","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-020-03320-7"},{"key":"cit0105","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-017-2006-6"},{"key":"cit0106","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.119.088062"},{"key":"cit0107","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-200308150-00001"},{"key":"cit0108","doi-asserted-by":"publisher","DOI":"10.1177\/0091270004269142"},{"key":"cit0109","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.10.6043"},{"key":"cit0110","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2012.34"},{"key":"cit0111","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks207"},{"key":"cit0112","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31826ebb5c"},{"key":"cit0113","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-015-0695-2"},{"key":"cit0114","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-13-205"},{"key":"cit0115","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw291"},{"key":"cit0116","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067946"},{"key":"cit0117","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2018.04.012"},{"key":"cit0118","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209788"},{"issue":"2","key":"cit0119","first-page":"311","volume":"49","author":"Schuetz EG","year":"1996","journal-title":"Mol Pharmacol"},{"key":"cit0120","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.9.4001"},{"key":"cit0121","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2003.10"},{"key":"cit0122","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e32834d672b"},{"key":"cit0123","doi-asserted-by":"publisher","DOI":"10.1021\/ja01184a023"},{"key":"cit0124","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1951.s1-31.212"},{"key":"cit0125","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)92371-8"},{"key":"cit0126","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.292.6522.721"},{"key":"cit0127","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)06217-4"},{"issue":"4","key":"cit0128","first-page":"493","volume":"68","author":"Phillips-Howard PA","year":"1990","journal-title":"Bull World Health Organ"},{"key":"cit0129","unstructured":"World Health Organization. Management of uncomplicated malaria and the use of antimalarial drugs for the protection of travellers: report of an informal consultation. Geneva: World Health Organization; 1995. (no. 18\u201321)."},{"key":"cit0130","first-page":"CD000016","author":"Olliaro P","year":"2003","journal-title":"Cochrane Database Syst Rev"},{"key":"cit0131","first-page":"CD007483","author":"Sinclair D","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"cit0132","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(20)30127-9"},{"key":"cit0133","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1879"},{"key":"cit0134","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-019-2724-z"},{"key":"cit0135","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.300.2.399"},{"key":"cit0136","first-page":"612","volume":"43","author":"Laurent F","year":"1993","journal-title":"Arzneimittelforschung"},{"key":"cit0137","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt513"},{"key":"cit0138","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(85)90285-1"},{"key":"cit0139","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.11.4089-4096.2004"},{"key":"cit0140","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-020-03553-6"},{"key":"cit0141","doi-asserted-by":"publisher","DOI":"10.1007\/BF00637639"},{"issue":"4","key":"cit0142","first-page":"409","volume":"383","author":"Mount DL","year":"1986","journal-title":"J Chromatogr"},{"key":"cit0143","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.108.025171"},{"key":"cit0144","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)80786-0"},{"key":"cit0145","unstructured":"PharmVar CYP2C8 [Internet]. Pharmacogene Variation Consortium; [cited 2021 Jun 08]. Available from: https:\/\/www.pharmvar.org\/gene\/CYP2C8"},{"key":"cit0146","doi-asserted-by":"publisher","DOI":"10.2174\/138920009790711832"},{"key":"cit0147","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2016.78"},{"key":"cit0148","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-004-0871-8"},{"key":"cit0149","first-page":"571","volume":"13","author":"Habtemikael L","year":"2020","journal-title":"Pharmgenomics Pers Med"},{"key":"cit0150","doi-asserted-by":"publisher","DOI":"10.1038\/sj.clpt.6100122"},{"key":"cit0151","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2005.73.826"},{"key":"cit0152","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir629"},{"key":"cit0153","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis736"},{"key":"cit0154","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis741"},{"key":"cit0155","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(92)90198-R"},{"key":"cit0156","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(95)00236-S"},{"key":"cit0157","doi-asserted-by":"publisher","DOI":"10.3109\/00498259509061845"},{"key":"cit0158","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13148"},{"key":"cit0159","doi-asserted-by":"publisher","DOI":"10.1042\/bss0610163"},{"key":"cit0160","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-009-0436-9"},{"key":"cit0161","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2008.11.006"},{"key":"cit0162","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2017.05.003"},{"key":"cit0163","doi-asserted-by":"publisher","DOI":"10.3109\/10408441003742895"},{"key":"cit0164","doi-asserted-by":"publisher","DOI":"10.1016\/S0070-2137(01)80009-1"},{"key":"cit0165","doi-asserted-by":"publisher","DOI":"10.1002\/biof.5520170111"},{"key":"cit0166","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-006-0121-3"},{"key":"cit0167","doi-asserted-by":"publisher","DOI":"10.1177\/0091270004270642"},{"key":"cit0168","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2004.02257.x"},{"key":"cit0169","doi-asserted-by":"publisher","DOI":"10.1186\/2049-9957-3-9"},{"key":"cit0170","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200565010-00004"},{"key":"cit0171","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2020.11.006"},{"key":"cit0172","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.12.5127-5128.2005"},{"key":"cit0173","doi-asserted-by":"publisher","DOI":"10.3109\/00498254.2012.693972"},{"key":"cit0174","doi-asserted-by":"publisher","DOI":"10.1002\/bip.23398"},{"key":"cit0175","doi-asserted-by":"publisher","DOI":"10.1007\/s13318-014-0182-0"},{"key":"cit0176","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-11-270"},{"key":"cit0177","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02716-14"},{"key":"cit0178","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.05.099"},{"key":"cit0179","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00708-06"},{"key":"cit0180","doi-asserted-by":"publisher","DOI":"10.1086\/319689"},{"key":"cit0181","doi-asserted-by":"publisher","DOI":"10.1086\/503051"},{"key":"cit0182","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-11-424"},{"issue":"2","key":"cit0183","first-page":"CD008152","volume":"2","author":"Graves PM","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"cit0184","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00011-19"},{"issue":"10","key":"cit0185","first-page":"6848","volume":"267","author":"V\u00e1squez-Vivar J","year":"1992","journal-title":"Oxidation and Redox Cycling. J Biol Chem"},{"key":"cit0186","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-12-212"},{"key":"cit0187","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(94)90022-1"},{"key":"cit0188","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11239-0"},{"key":"cit0189","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-11-259"},{"key":"cit0190","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2020.12.004"},{"key":"cit0191","doi-asserted-by":"publisher","DOI":"10.1038\/sj.tpj.6500285"},{"key":"cit0192","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-003-0832-2"},{"key":"cit0193","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-008-2291-6"},{"key":"cit0194","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2012.12.007"},{"key":"cit0195","unstructured":"PharmVar CYP2D6 [Internet]. Pharmacogene Variation Consortium; [cited 2021 Jun 08]. Available from: https:\/\/www.pharmvar.org\/gene\/CYP2D6"},{"key":"cit0196","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2016.80"},{"key":"cit0197","doi-asserted-by":"publisher","DOI":"10.1038\/sj.clpt.6100406"},{"key":"cit0198","doi-asserted-by":"publisher","DOI":"10.3390\/jpm8020015"},{"key":"cit0199","doi-asserted-by":"publisher","DOI":"10.2174\/1389200215666140202215316"},{"key":"cit0200","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1301936"},{"key":"cit0201","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2020.12.001"},{"key":"cit0202","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-017-2139-7"},{"key":"cit0203","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2018.1449"},{"key":"cit0204","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02056-19"},{"key":"cit0205","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiz386"},{"key":"cit0206","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00015-15"},{"key":"cit0207","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00538-19"},{"key":"cit0208","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.15085"},{"key":"cit0209","volume-title":"Testing for G6PD deficiency for safe use of primaquine in radical cure of P. vivax and P. ovale malaria","author":"World Health Organization","year":"2016"},{"key":"cit0210","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151898"},{"key":"cit0211","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0190272"},{"key":"cit0212","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-016-1145-5"},{"key":"cit0213","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1710775"},{"key":"cit0214","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00343-15"},{"key":"cit0215","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-13-2"},{"key":"cit0216","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-016-1632-8"},{"key":"cit0217","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2017.03.002"},{"key":"cit0218","doi-asserted-by":"publisher","DOI":"10.1021\/jm2003359"},{"key":"cit0219","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02727-13"},{"key":"cit0220","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602250"},{"key":"cit0221","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa952"},{"key":"cit0222","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-017-2162-8"},{"key":"cit0223","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-38871"},{"key":"cit0224","doi-asserted-by":"publisher","DOI":"10.1038\/nature02779"},{"key":"cit0225","doi-asserted-by":"publisher","DOI":"10.1086\/655831"},{"key":"cit0226","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-015-0982-y"},{"key":"cit0227","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw029"},{"key":"cit0228","doi-asserted-by":"publisher","DOI":"10.1177\/0091270010385578"},{"key":"cit0229","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2008.01.087"},{"key":"cit0230","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1015762108"},{"key":"cit0231","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00320-5"},{"key":"cit0232","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.104.003202"},{"key":"cit0233","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05359-11"},{"key":"cit0234","doi-asserted-by":"publisher","DOI":"10.2217\/FMB.15.60"},{"key":"cit0235","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-6-70"},{"key":"cit0236","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix1122"},{"key":"cit0237","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-7-225"},{"key":"cit0238","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-011112-140317"},{"key":"cit0239","unstructured":"Guttmann P, Ehrlich P. Ueber die Wirkung des Methylenblau bei Malaria [Effect of methylene blue in malaria]. Vol. 28. German: Berlin Klin Wochenschr; 1891. p. 953\u2013956."},{"key":"cit0240","first-page":"292","volume":"1","author":"Couto M","year":"1908","journal-title":"Bull Soc Pathol Exot"},{"key":"cit0241","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30044-6"},{"key":"cit0242","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu540"},{"key":"cit0243","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01441-19"},{"key":"cit0244","unstructured":"Highlights of prescribing information: PROVAYBLUETM [Internet]. Washintong (DC): U.S. Food and Drug Administration; [cited 2021 Jun 08]. Available from: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2016\/204630s000lbl.pdf"},{"key":"cit0245","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1998.3087"},{"key":"cit0246","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0152677"},{"key":"cit0247","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e32836498f4"},{"key":"cit0248","doi-asserted-by":"publisher","DOI":"10.2165\/11536520-000000000-00000"},{"key":"cit0249","doi-asserted-by":"publisher","DOI":"10.2165\/11597790-000000000-00000"},{"key":"cit0250","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3370"},{"key":"cit0251","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe0708842"},{"key":"cit0252","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.16-0552"},{"key":"cit0253","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.12.009"},{"key":"cit0254","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k698"},{"key":"cit0255","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2020.06.008"}],"container-title":["Expert Opinion on Drug Metabolism &amp; Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17425255.2022.2049235","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T15:00:28Z","timestamp":1649689228000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17425255.2022.2049235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,2]]},"references-count":255,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1,2]]}},"alternative-id":["10.1080\/17425255.2022.2049235"],"URL":"https:\/\/doi.org\/10.1080\/17425255.2022.2049235","relation":{},"ISSN":["1742-5255","1744-7607"],"issn-type":[{"value":"1742-5255","type":"print"},{"value":"1744-7607","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,2]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iemt20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iemt20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2021-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}