{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T01:11:44Z","timestamp":1768439504137,"version":"3.49.0"},"reference-count":57,"publisher":"Informa UK Limited","issue":"12","funder":[{"DOI":"10.13039\/501100002924","name":"FEDER","doi-asserted-by":"publisher","award":["PT2020"],"award-info":[{"award-number":["PT2020"]}],"id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT)","doi-asserted-by":"publisher","award":["PD\/BD\/135103\/2017"],"award-info":[{"award-number":["PD\/BD\/135103\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"FCT\/Minist\u00e9rio da Educa\u00e7\u00e3o e Ci\u00eancia (MEC)","award":["UID\/QUI\/00062\/2013"],"award-info":[{"award-number":["UID\/QUI\/00062\/2013"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Drug Discovery"],"published-print":{"date-parts":[[2018,12,2]]},"DOI":"10.1080\/17460441.2018.1543267","type":"journal-article","created":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T04:56:28Z","timestamp":1542689788000},"page":"1141-1151","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":21,"title":["Chromones: privileged scaffolds for the production of multi-target-directed-ligand agents for the treatment of Alzheimer\u2019s disease"],"prefix":"10.1080","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2861-8286","authenticated-orcid":false,"given":"Carlos F. M.","family":"Silva","sequence":"first","affiliation":[{"name":"Department of Chemistry & QOPNA, University of Aveiro, Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4249-7089","authenticated-orcid":false,"given":"Diana C. G. A.","family":"Pinto","sequence":"additional","affiliation":[{"name":"Department of Chemistry & QOPNA, University of Aveiro, Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2861-8286","authenticated-orcid":false,"given":"Artur M. S.","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Chemistry & QOPNA, University of Aveiro, Aveiro, Portugal"}]}],"member":"301","published-online":{"date-parts":[[2018,11,15]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.5b01055"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1021\/cr400265z"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.03.047"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b01720"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1021\/np0503808"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1021\/cn400213r"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1021\/jm050635e"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1038\/srep18440"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1039\/c1fo10098j"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201600359"},{"key":"CIT0013","author":"Prince M","year":"2015","journal-title":"Alzheimer\u2019s Disease International, editor"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.2174\/1568015053202723"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(91)90609-V"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000129697.01779.0A"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)91936-X"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1126\/science.7058341"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.66.2.137"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2000.7397"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1126\/science.7046051"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2003.11.017"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80108-7"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1021\/bi0101392"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-09-03213.1998"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1126\/science.1566067"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2008.12.015"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2015.06.008"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2420"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201606210"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.12.1317"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)02031-2"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.2174\/092986708785909111"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-005-5597-y"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-007-7220-x"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2014.2040"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.6b00309"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1080\/14756360802187885"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2009.07.072"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2003.12.017"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2010.12.001"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2014.12.008"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2015.01.005"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.04.005"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0146197"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2015.12.031"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2008.01.017"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2010.06.021"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2011.03.060"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2015.10.036"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1021\/jm201460y"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2013.09.024"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.06.022"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2013.02.095"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2013.09.061"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.02.045"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2015.01.042"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1002\/jhet.5570410401"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.13005\/ojc\/290425"}],"container-title":["Expert Opinion on Drug Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/17460441.2018.1543267","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T08:50:19Z","timestamp":1544431819000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17460441.2018.1543267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,15]]},"references-count":57,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2018,10,25]]},"published-print":{"date-parts":[[2018,12,2]]}},"alternative-id":["10.1080\/17460441.2018.1543267"],"URL":"https:\/\/doi.org\/10.1080\/17460441.2018.1543267","relation":{},"ISSN":["1746-0441","1746-045X"],"issn-type":[{"value":"1746-0441","type":"print"},{"value":"1746-045X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,15]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iedc20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iedc20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2018-07-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}