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Among the key messages was broad agreement about the importance of biospecimen science. Much greater attention needs to be paid towards the provenance of collected samples. The workshop also highlighted clear gaps in our knowledge about pre\u2010analytical factors that alter extracellular vesicles (EVs). The future utility of certified standards for credentialing of instruments and software, to analyse EV and for tracking the influence of isolation steps on the structure and content of EVs were also discussed. Several example studies were presented, demonstrating the potential utility for EVs in disease diagnosis, prognosis, longitudinal serial testing and stratification of patients. The conclusion of the workshop was that more effort focused on pre\u2010analytical issues and benchmarking of isolation methods is needed to strengthen collaborations and advance more effective biomarkers.<\/jats:p>","DOI":"10.1080\/20013078.2018.1473707","type":"journal-article","created":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T10:25:35Z","timestamp":1526552735000},"update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":56,"title":["Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3087-9226","authenticated-orcid":false,"given":"Aled","family":"Clayton","sequence":"first","affiliation":[{"name":"Tissue Microenvironment Group School of Medicine Cardiff University Cardiff UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0460-6459","authenticated-orcid":false,"given":"Dominik","family":"Buschmann","sequence":"additional","affiliation":[{"name":"Division of Animal Physiology and Immunology Technical University of Munich and Institute of Human Genetics University Hospital, LMU Munich Munich Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0509-3520","authenticated-orcid":false,"given":"J. 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