{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T07:24:58Z","timestamp":1770967498754,"version":"3.50.1"},"reference-count":68,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1997,11,3]]},"abstract":"<jats:p>Localization of maternally provided RNAs during oogenesis is required for formation of the antero\u2013posterior axis of the Drosophila embryo. Here we describe a subcellular structure in nurse cells and oocytes which may function as an intracellular compartment for assembly and transport of maternal products involved in RNA localization. This structure, which we have termed \u201csponge body,\u201d consists of ER-like cisternae, embedded in an amorphous electron-dense mass. It lacks a surrounding membrane and is frequently associated with mitochondria. The sponge bodies are not identical to the Golgi complexes. We suggest that the sponge bodies are homologous to the mitochondrial cloud in Xenopus oocytes, a granulo-fibrillar structure that contains RNAs involved in patterning of the embryo.<\/jats:p>\n               <jats:p>Exuperantia protein, the earliest factor known to be required for the localization of bicoid mRNA to the anterior pole of the Drosophila oocyte, is highly enriched in the sponge bodies but not an essential structural component of these. RNA staining indicates that sponge bodies contain RNA. However, neither the intensity of this staining nor the accumulation of Exuperantia in the sponge bodies is dependent on the amount of bicoid mRNA present in the ovaries. Sponge bodies surround nuage, a possible polar granule precursor. Microtubules and microfilaments are not present in sponge bodies, although transport of the sponge bodies through the cells is implied by their presence in cytoplasmic bridges. We propose that the sponge bodies are structures that, by assembly and transport of included molecules or associated structures, are involved in localization of mRNAs in Drosophila oocytes.<\/jats:p>","DOI":"10.1083\/jcb.139.3.817","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:47:50Z","timestamp":1027702070000},"page":"817-829","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":111,"title":["A Sponge-like Structure Involved in the Association and Transport of Maternal Products during <i>Drosophila<\/i> Oogenesis"],"prefix":"10.1083","volume":"139","author":[{"given":"Michaela","family":"Wilsch-Br\u00e4uninger","sequence":"first","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Entwicklungsbiologie, D-72076 T\u00fcbingen, Germany"}]},{"given":"Heinz","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Entwicklungsbiologie, D-72076 T\u00fcbingen, Germany"}]},{"given":"Christiane","family":"N\u00fcsslein-Volhard","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Entwicklungsbiologie, D-72076 T\u00fcbingen, Germany"}]}],"member":"291","published-online":{"date-parts":[[1997,11,3]]},"reference":[{"key":"2023072207174523500_B1","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1002\/j.1460-2075.1988.tb03004.x","article-title":"The role of localization of bicoid RNA in organizing the anterior pattern of the Drosophilaembryo","volume":"7","author":"Berleth","year":"1988","journal-title":"EMBO (Eur Mol Biol Organ) J"},{"key":"2023072207174523500_B2","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/S0022-5320(69)80016-X","article-title":"A new staining procedure for electron microscopical cytology","volume":"27","author":"Bernhard","year":"1969","journal-title":"J Ultrastruct Res"},{"key":"2023072207174523500_B3","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1242\/jcs.107.4.849","article-title":"Cytoskeleton-dependent transport of cytoplasmic particles in previtellogenic to mid-vitellogenic ovarian follicles of Drosophila: time-lapse analysis using video-enhanced contrast microscopy","volume":"107","author":"Bohrmann","year":"1994","journal-title":"J Cell Sci"},{"key":"2023072207174523500_B4","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1101\/gad.10.17.2179","article-title":"Oskar protein interaction with Vasa represents an essential step in polar granule assembly","volume":"10","author":"Breitwieser","year":"1996","journal-title":"Genes Dev"},{"key":"2023072207174523500_B5","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1242\/jcs.109.8.2031","article-title":"Actin filament bundles are required for microtubule reorientation during growth cone turning to avoid an inhibitory guidance cue","volume":"109","author":"Challacombe","year":"1996","journal-title":"J Cell Sci"},{"key":"2023072207174523500_B6","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/dvg.1020120502","article-title":"Sequence of swallow, a gene required for the localization of bicoid message in Drosophilaeggs","volume":"12","author":"Chao","year":"1991","journal-title":"Dev Genet"},{"key":"2023072207174523500_B7","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0960-9822(00)00068-3","article-title":"Transient posterior localization of a kinesin fusion protein reflects anteroposterior polarity of the Drosophilaoocyte","volume":"4","author":"Clark","year":"1994","journal-title":"Curr Biol"},{"key":"2023072207174523500_B8","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1126\/science.7939713","article-title":"Cytoskeletal functions during Drosophilaoogenesis","volume":"266","author":"Cooley","year":"1994","journal-title":"Science (Wash DC)"},{"key":"2023072207174523500_B9","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0092-8674(88)90183-3","article-title":"The bicoid protein determines position in the Drosophilaembryo in a concentration-dependent manner","volume":"54","author":"Driever","year":"1988","journal-title":"Cell"},{"key":"2023072207174523500_B10","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0092-8674(88)90182-1","article-title":"A gradient of bicoid protein in Drosophilaembryos","volume":"54","author":"Driever","year":"1988","journal-title":"Cell"},{"key":"2023072207174523500_B11","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/337138a0","article-title":"The bicoid protein is a positive regulator of hunchback transcription in the early Drosophilaembryo","volume":"337","author":"Driever","year":"1989","journal-title":"Nature (Lond)"},{"key":"2023072207174523500_B12","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0074-7696(08)60070-4","article-title":"Germ plasm and the differentiation of the germ cell line","volume":"43","author":"Eddy","year":"1975","journal-title":"Int Rev Cytol"},{"key":"2023072207174523500_B13","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1101\/gad.9.20.2482","article-title":"cappuccino, a Drosophilamaternal effect gene required for polarity of the egg and embryo, is related to the vertebrate limb deformity locus","volume":"9","author":"Emmons","year":"1995","journal-title":"Genes Dev"},{"key":"2023072207174523500_B14","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0092-8674(91)90137-N","article-title":"oskar organizes the germ plasm and directs localization of the posterior determinant nanos.","volume":"66","author":"Ephrussi","year":"1991","journal-title":"Cell"},{"key":"2023072207174523500_B15","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/377524a0","article-title":"Requirement for Drosophila cytoplasmic tropomyosin in oskarmRNA localization","volume":"377","author":"Erdelyi","year":"1995","journal-title":"Nature (Lond)"},{"key":"2023072207174523500_B16","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/0092-8674(94)90013-2","article-title":"Staufen protein associates with the 3\u2032UTR of bicoidmRNA to form particles that move in a microtubule-dependent manner","volume":"79","author":"Ferrandon","year":"1994","journal-title":"Cell"},{"key":"2023072207174523500_B17","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1242\/jcs.109.8.2041","article-title":"Function of spindle microtubules in directing cortical movement and actin filament organization in dividing cultured cells","volume":"109","author":"Fishkind","year":"1996","journal-title":"J Cell Sci"},{"key":"2023072207174523500_B18","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1242\/dev.121.1.201","article-title":"Patterns of localization and cytoskeletal association of two vegetally localized RNAs, Vg1 and Xcat2.","volume":"121","author":"Forristall","year":"1995","journal-title":"Development (Camb)"},{"key":"2023072207174523500_B19","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/0092-8674(86)90516-7","article-title":"Structure of the segmentation genes paired and the Drosophila PRDgene set as part of a gene network","volume":"47","author":"Frigerio","year":"1986","journal-title":"Cell"},{"key":"2023072207174523500_B20","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/324120a0","article-title":"Organization of anterior pattern in the Drosophila embryo by the maternal gene bicoid.","volume":"324","author":"Frohnh\u00f6fer","year":"1986","journal-title":"Nature (Lond)"},{"key":"2023072207174523500_B21","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1101\/gad.1.8.880","article-title":"Maternal genes required for the anterior localization of bicoid activity in the embryo of Drosophila.","volume":"1","author":"Frohnh\u00f6fer","year":"1987","journal-title":"Genes Dev"},{"key":"2023072207174523500_B22","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0074-7696(08)61664-2","article-title":"Recent advances in the morphology, cytochemistry, and function of Balbiani's vitelline body in animal oocytes","volume":"59","author":"Guraya","year":"1979","journal-title":"Int Rev Cytol"},{"key":"2023072207174523500_B23","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1242\/dev.103.4.625","article-title":"Identification of a component of Drosophilapolar granules","volume":"103","author":"Hay","year":"1988","journal-title":"Development (Camb)"},{"key":"2023072207174523500_B24","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/0092-8674(88)90216-4","article-title":"A protein component of Drosophila polar granules is encoded by vasaand has extensive sequence similarity to ATP-dependent helicases","volume":"55","author":"Hay","year":"1988","journal-title":"Cell"},{"key":"2023072207174523500_B25","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1093\/genetics\/126.3.607","article-title":"The exuperantia gene is required for Drosophilaspermatogenesis as well as anteroposterior polarity of the developing oocyte, and encodes overlapping sex-specific transcripts","volume":"126","author":"Hazelrigg","year":"1990","journal-title":"Genetics"},{"key":"2023072207174523500_B26","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/0012-1606(84)90303-8","article-title":"The mitochondrial cloud of Xenopusoocytes: the source of germinal granule material","volume":"105","author":"Heasman","year":"1984","journal-title":"Dev Biol"},{"key":"2023072207174523500_B27","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1242\/dev.119.2.457","article-title":"Distribution of swallow protein in egg chambers and embryos of Drosophilamelanogaster","volume":"119","author":"Hedge","year":"1993","journal-title":"Development (Camb)"},{"key":"2023072207174523500_B28","first-page":"68","article-title":"Note sur la vesicule de Balbiani","volume":"39","author":"Henneguy","year":"1887","journal-title":"C R Seances Soc Biol Ses Fil"},{"key":"2023072207174523500_B29","first-page":"192","article-title":"The histology of the cytoplasmic elements during vitellogenesis in Drosophila melanogaster.","volume":"93","author":"Hsu","year":"1952","journal-title":"Q J Microsc Sci"},{"key":"2023072207174523500_B30","first-page":"23","article-title":"The origin of proteid yolk in Drosophila melanogaster.","volume":"94","author":"Hsu","year":"1953","journal-title":"Q J Microsc Sci"},{"key":"2023072207174523500_B31","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0092-8674(91)90136-M","article-title":"oskar mRNA is localized to the posterior pole of the Drosophilaoocyte","volume":"66","author":"Kim-Ha","year":"1991","journal-title":"Cell"},{"key":"2023072207174523500_B32"},{"key":"2023072207174523500_B33","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1242\/dev.121.2.287","article-title":"Two distinct pathways for the localization of RNAs at the vegetal cortex in Xenopusoocytes","volume":"121","author":"Kloc","year":"1995","journal-title":"Development (Camb)"},{"key":"2023072207174523500_B34","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/335611a0","article-title":"The product of the Drosophila gene vasais very similar to eukaryotic initiation factor-4A","volume":"335","author":"Lasko","year":"1988","journal-title":"Nature (Lond)"},{"key":"2023072207174523500_B35","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1101\/gad.4.6.905","article-title":"Posterior localization of vasaprotein correlates with, but is not sufficient for, pole cell development","volume":"4","author":"Lasko","year":"1990","journal-title":"Genes Dev"},{"key":"2023072207174523500_B36","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1242\/dev.124.2.353","article-title":"\u03b1-Spectrin is required for ovarian follicle monolayer integrity in Drosophila melanogaster.","volume":"124","author":"Lee","year":"1997","journal-title":"Development (Camb)"},{"key":"2023072207174523500_B37","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0092-8674(86)90375-2","article-title":"Abdominal segmentation, pole cell formation, and embryonic polarity require the localized activity of oskar, a maternal gene in Drosophila.","volume":"47","author":"Lehmann","year":"1986","journal-title":"Cell"},{"key":"2023072207174523500_B38","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1242\/dev.120.5.1201","article-title":"Localization of vasa protein to the Drosophilapole plasm is independent of its RNA-binding and helicase activities","volume":"120","author":"Liang","year":"1994","journal-title":"Development (Camb)"},{"key":"2023072207174523500_B39","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1242\/dev.120.4.947","article-title":"The Drosophilafusome, a germline-specific organelle, contains membrane skeletal proteins and functions in cyst formation","volume":"120","author":"Lin","year":"1994","journal-title":"Development (Camb)"},{"key":"2023072207174523500_B40","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/336595a0","article-title":"Cis-acting sequences responsible for anterior localization of bcd mRNA in Drosophilaembryos","volume":"336","author":"Macdonald","year":"1988","journal-title":"Nature (Lond)"},{"key":"2023072207174523500_B41","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1101\/gad.5.12b.2455","article-title":"Protein encoded by the exuperantia gene is concentrated at sites of bicoid mRNA accumulation in Drosophilanurse cells but not in oocytes or embryos","volume":"5","author":"Macdonald","year":"1991","journal-title":"Genes Dev"},{"key":"2023072207174523500_B42","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1242\/dev.118.4.1233","article-title":"RNA regulatory element BLE1 directs the early steps of bicoidmRNA localization","volume":"118","author":"Macdonald","year":"1993","journal-title":"Development (Camb)"},{"key":"2023072207174523500_B43","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/jez.1401510302","article-title":"Fine structure of pole cells and polar granules in Drosophila melanogaster.","volume":"151","author":"Mahowald","year":"1962","journal-title":"J Exp Zool"},{"key":"2023072207174523500_B44","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/jez.1401760308","article-title":"Polar granules of Drosophila: III. The continuity of polar granules during the life cycle of Drosophila.","volume":"176","author":"Mahowald","year":"1971","journal-title":"J Exp Zool"},{"key":"2023072207174523500_B45","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/jez.1401760309","article-title":"Polar granules of Drosophila: IV. Cytochemical studies showing loss of RNA from polar granules during early stages of embryogenesis","volume":"176","author":"Mahowald","year":"1971","journal-title":"J Exp Zool"},{"key":"2023072207174523500_B46","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1126\/science.1372132","article-title":"Germ plasm revisited and illuminated","volume":"255","author":"Mahowald","year":"1992","journal-title":"Science (Wash DC)"},{"key":"2023072207174523500_B47"},{"key":"2023072207174523500_B48","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1242\/dev.122.7.2109","article-title":"Profilin is required for posterior patterning of the Drosophilaoocyte","volume":"122","author":"Manseau","year":"1996","journal-title":"Development (Camb)"},{"key":"2023072207174523500_B49","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1101\/gad.3.9.1437","article-title":"cappuccino and spire: two unique maternal-effect loci required for both the anteroposterior and dorsoventral patterns of the Drosophilaembryo","volume":"3","author":"Manseau","year":"1989","journal-title":"Genes Dev"},{"key":"2023072207174523500_B50","doi-asserted-by":"crossref","first-page":"4259","DOI":"10.1002\/j.1460-2075.1991.tb05004.x","article-title":"The temporal and spatial distribution pattern of maternal exuperantia protein: evidence for a role in establishment but not maintenance of bicoidmRNA localization","volume":"10","author":"Marcey","year":"1991","journal-title":"EMBO (Eur Mol Biol Organ) J"},{"key":"2023072207174523500_B51","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.1101\/gad.8.22.2718","article-title":"Direct control of transcription of the Drosophila morphogen bicoidby the Serendipity \u03b4 zinc finger protein, as revealed by in vivo analysis of a finger swap","volume":"8","author":"Payre","year":"1994","journal-title":"Genes Dev"},{"key":"2023072207174523500_B52","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1242\/jcs.109.5.981","article-title":"A high molecular mass non-muscle tropomyosin isoform stimulates retrograde organelle transport","volume":"109","author":"Pelham","year":"1996","journal-title":"J Cell Sci"},{"key":"2023072207174523500_B53","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1242\/dev.113.1.55","article-title":"Microtubules mediate the localization of bicoid RNA during Drosophilaoogenesis","volume":"113","author":"Pokrywka","year":"1991","journal-title":"Development (Camb)"},{"key":"2023072207174523500_B54","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1006\/dbio.1995.1030","article-title":"Microtubules are a general component of mRNA localization systems in Drosophilaoocytes","volume":"167","author":"Pokrywka","year":"1995","journal-title":"Dev Biol"},{"key":"2023072207174523500_B55"},{"key":"2023072207174523500_B56","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0092-8674(92)90466-P","article-title":"The origin of pattern and polarity in the Drosophilaembryo","volume":"68","author":"St Johnston","year":"1992","journal-title":"Cell"},{"key":"2023072207174523500_B57"},{"key":"2023072207174523500_B58","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0092-8674(91)90138-O","article-title":"staufen, a gene required to localize maternal RNAs in the Drosophilaegg","volume":"66","author":"St Johnston","year":"1991","journal-title":"Cell"},{"key":"2023072207174523500_B59","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/216173a0","article-title":"Fixation of ejaculated spermatozoa for electron microscopy","volume":"216","author":"Stefanini","year":"1967","journal-title":"Nature (Lond)"},{"key":"2023072207174523500_B60","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1101\/gad.2.12a.1655","article-title":"Molecular analysis of the swallow gene of Drosophila melanogaster.","volume":"2","author":"Stephenson","year":"1988","journal-title":"Genes Dev"},{"key":"2023072207174523500_B61","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/BF00291041","article-title":"A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback.","volume":"98","author":"Tautz","year":"1989","journal-title":"Chromosome"},{"key":"2023072207174523500_B62","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1006\/dbio.1994.1258","article-title":"Microtubules and cytoplasm organization during Drosophilaoogenesis","volume":"165","author":"Theurkauf","year":"1994","journal-title":"Dev Biol"},{"key":"2023072207174523500_B63","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1126\/science.8091233","article-title":"Premature microtubule-dependent cytoplasmic streaming in cappuccino and spiremutant oocytes","volume":"265","author":"Theurkauf","year":"1994","journal-title":"Science (Wash DC)"},{"key":"2023072207174523500_B64","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1242\/dev.115.4.923","article-title":"Reorganization of the cytoskeleton during Drosophilaoogenesis: implications for axis specification and intercellular transport","volume":"115","author":"Theurkauf","year":"1992","journal-title":"Development (Camb)"},{"key":"2023072207174523500_B65","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/369400a0","article-title":"Implications for bcd mRNA localization from spatial distribution of exu protein in Drosophilaoogenesis","volume":"369","author":"Wang","year":"1994","journal-title":"Nature (Lond)"},{"key":"2023072207174523500_B66","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1440-169X.1992.tb00011.x","article-title":"Immuno-localization of DEAD family proteins in germ line cells of Xenopusembryos","volume":"34","author":"Watanabe","year":"1992","journal-title":"Dev Growth Differ"},{"key":"2023072207174523500_B67","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/0092-8674(89)90611-9","article-title":"Structure of the Drosophila BicaudalD protein and its role in localizing the posterior determinant nanos.","volume":"59","author":"Wharton","year":"1989","journal-title":"Cell"},{"key":"2023072207174523500_B68","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1083\/jcb.123.2.269","article-title":"RNA on the move: the mRNA localization pathway","volume":"123","author":"Wilhelm","year":"1993","journal-title":"J Cell Biol"}],"container-title":["The Journal of Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/139\/3\/817\/1487881\/15020.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/139\/3\/817\/1487881\/15020.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,22]],"date-time":"2023-07-22T07:19:03Z","timestamp":1690010343000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jcb\/article\/139\/3\/817\/769\/A-Sponge-like-Structure-Involved-in-the"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,11,3]]},"references-count":68,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1997,11,3]]}},"URL":"https:\/\/doi.org\/10.1083\/jcb.139.3.817","relation":{},"ISSN":["0021-9525","1540-8140"],"issn-type":[{"value":"0021-9525","type":"print"},{"value":"1540-8140","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,11,3]]}}}