{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:05:57Z","timestamp":1779343557103,"version":"3.51.4"},"reference-count":74,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1999,5,17]]},"abstract":"<jats:p>We have used digital fluorescence imaging techniques to explore the interplay between mitochondrial Ca2+ uptake and physiological Ca2+ signaling in rat cortical astrocytes. A rise in cytosolic Ca2+ ([Ca2+]cyt), resulting from mobilization of ER Ca2+ stores was followed by a rise in mitochondrial Ca2+ ([Ca2+]m, monitored using rhod-2). Whereas [Ca2+]cyt recovered within \u223c1 min, the time to recovery for [Ca2+]m was \u223c30 min. Dissipating the mitochondrial membrane potential (\u0394\u03c8m, using the mitochondrial uncoupler carbonyl cyanide p-trifluoromethoxy-phenyl-hydrazone [FCCP] with oligomycin) prevented mitochondrial Ca2+ uptake and slowed the rate of decay of [Ca2+]cyt transients, suggesting that mitochondrial Ca2+ uptake plays a significant role in the clearance of physiological [Ca2+]cyt loads in astrocytes. Ca2+ signals in these cells initiated either by receptor-mediated ER Ca2+ release or mechanical stimulation often consisted of propagating waves (measured using fluo-3). In response to either stimulus, the wave traveled at a mean speed of 22.9 \u00b1 11.2 \u03bcm\/s (n = 262). This was followed by a wave of mitochondrial depolarization (measured using tetramethylrhodamine ethyl ester [TMRE]), consistent with Ca2+ uptake into mitochondria as the Ca2+ wave traveled across the cell. Collapse of \u0394\u03c8m to prevent mitochondrial Ca2+ uptake significantly increased the rate of propagation of the Ca2+ waves by 50%. Taken together, these data suggest that cytosolic Ca2+ buffering by mitochondria provides a potent mechanism to regulate the localized spread of astrocytic Ca2+ signals.<\/jats:p>","DOI":"10.1083\/jcb.145.4.795","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:45:41Z","timestamp":1027701941000},"page":"795-808","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":253,"title":["Mitochondria Exert a Negative Feedback on the Propagation of Intracellular Ca2+ Waves in Rat Cortical Astrocytes"],"prefix":"10.1083","volume":"145","author":[{"given":"Eric","family":"Boitier","sequence":"first","affiliation":[{"name":"Department of Physiology, University College London, London, WC1E 6BT, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Rea","sequence":"additional","affiliation":[{"name":"Department of Physiology, University College London, London, WC1E 6BT, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"Duchen","sequence":"additional","affiliation":[{"name":"Department of Physiology, University College London, London, WC1E 6BT, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1999,5,17]]},"reference":[{"key":"2023072901324801400_B1","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/367745a0","article-title":"The nucleus is insulated from large cytosolic calcium ion changes","volume":"367","author":"al Mohanna, F.A., K.W. 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