{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T08:09:16Z","timestamp":1776240556043,"version":"3.50.1"},"reference-count":47,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2000,2,7]]},"abstract":"<jats:p>Classical cadherins form parallel cis-dimers that emanate from a single cell surface. It is thought that the cis-dimeric form is active in cell\u2013cell adhesion, whereas cadherin monomers are likely to be inactive. Currently, cis-dimers have been shown to exist only between cadherins of the same type. Here, we show the specific formation of cis-heterodimers between N- and R-cadherins. E-cadherin cannot participate in these complexes. Cells coexpressing N- and R-cadherins show homophilic adhesion in which these proteins coassociate at cell\u2013cell interfaces. We performed site- directed mutagenesis studies, the results of which support the strand dimer model for cis-dimerization. Furthermore, we show that when N- and R-cadherins are coexpressed in neurons in vitro, the two cadherins colocalize at certain neural synapses, implying biological relevance for these complexes. The present study provides a novel paradigm for cadherin interaction whereby selective cis-heterodimer formation may generate new functional units to mediate cell\u2013cell adhesion.<\/jats:p>","DOI":"10.1083\/jcb.148.3.579","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:45:41Z","timestamp":1027701941000},"page":"579-590","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":159,"title":["Functional Cis-Heterodimers of N- and R-Cadherins"],"prefix":"10.1083","volume":"148","author":[{"given":"Wei-Song","family":"Shan","sequence":"first","affiliation":[{"name":"aDepartment of Biochemistry and Molecular Biology, Programs in Cell Adhesion and Structural Biology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidekazu","family":"Tanaka","sequence":"additional","affiliation":[{"name":"aDepartment of Biochemistry and Molecular Biology, Programs in Cell Adhesion and Structural Biology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greg R.","family":"Phillips","sequence":"additional","affiliation":[{"name":"aDepartment of Biochemistry and Molecular Biology, Programs in Cell Adhesion and Structural Biology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten","family":"Arndt","sequence":"additional","affiliation":[{"name":"aDepartment of Biochemistry and Molecular Biology, Programs in Cell Adhesion and Structural Biology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika","family":"Yoshida","sequence":"additional","affiliation":[{"name":"aDepartment of Biochemistry and Molecular Biology, Programs in Cell Adhesion and Structural Biology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Colman","sequence":"additional","affiliation":[{"name":"aDepartment of Biochemistry and Molecular Biology, Programs in Cell Adhesion and Structural Biology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence","family":"Shapiro","sequence":"additional","affiliation":[{"name":"bDepartment of Physiology and Biophysics, The Mount Sinai School of Medicine of New York University, New York, New York 10029"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[2000,2,7]]},"reference":[{"key":"2023072902085973000_Arndtetal1998","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1006\/mcne.1998.0665","article-title":"Cadherin-defined segments and parasagittal cell ribbons in the developing chicken cerebellum","volume":"10","author":"Arndt","year":"1998","journal-title":"Mol. 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