{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:15:25Z","timestamp":1779344125799,"version":"3.51.4"},"reference-count":106,"publisher":"Rockefeller University Press","issue":"7","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2000,6,26]]},"abstract":"<jats:p>The activity of the cyclin-dependent kinase 1 (Cdk1), Cdc28, inhibits the transition from anaphase to G1 in budding yeast. CDC28-T18V, Y19F (CDC28-VF), a mutant that lacks inhibitory phosphorylation sites, delays the exit from mitosis and is hypersensitive to perturbations that arrest cells in mitosis. Surprisingly, this behavior is not due to a lack of inhibitory phosphorylation or increased kinase activity, but reflects reduced activity of the anaphase-promoting complex (APC), a defect shared with other mutants that lower Cdc28\/Clb activity in mitosis. CDC28-VF has reduced Cdc20- dependent APC activity in mitosis, but normal Hct1- dependent APC activity in the G1 phase of the cell cycle. The defect in Cdc20-dependent APC activity in CDC28-VF correlates with reduced association of Cdc20 with the APC. The defects of CDC28-VF suggest that Cdc28 activity is required to induce the metaphase to anaphase transition and initiate the transition from anaphase to G1 in budding yeast.<\/jats:p>","DOI":"10.1083\/jcb.149.7.1361","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:45:41Z","timestamp":1027701941000},"page":"1361-1376","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":75,"title":["Cdc28 Activates Exit from Mitosis in Budding Yeast"],"prefix":"10.1083","volume":"149","author":[{"given":"Adam D.","family":"Rudner","sequence":"first","affiliation":[{"name":"aDepartment of Physiology, University of California, San Francisco, California 94143-0444"},{"name":"bDepartment of Biochemistry, University of California, San Francisco, California 94143-0444"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin G.","family":"Hardwick","sequence":"additional","affiliation":[{"name":"aDepartment of Physiology, University of California, San Francisco, California 94143-0444"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew W.","family":"Murray","sequence":"additional","affiliation":[{"name":"aDepartment of Physiology, University of California, San Francisco, California 94143-0444"},{"name":"bDepartment of Biochemistry, University of California, San Francisco, California 94143-0444"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[2000,6,26]]},"reference":[{"key":"2023072902201036200_Alexandruetal1999","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1093\/emboj\/18.10.2707","article-title":"Sister chromatid separation and chromosome re-duplication are regulated by different mechanisms in response to spindle damage","volume":"18","author":"Alexandru","year":"1999","journal-title":"EMBO (Eur. Mol. Biol. Organ.) J."},{"key":"2023072902201036200_Amon1997","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1093\/emboj\/16.10.2693","article-title":"Regulation of B-type cyclin proteolysis by Cdc28-associated kinases in budding yeast","volume":"16","author":"Amon","year":"1997","journal-title":"EMBO (Eur. Mol. Biol. Organ.) J."},{"key":"2023072902201036200_Amonetal1992","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/355368a0","article-title":"Regulation of p34CDC28 tyrosine phosphorylation is not required for entry into mitosis in S. cerevisiae","volume":"355","author":"Amon","year":"1992","journal-title":"Nature"},{"key":"2023072902201036200_Bigginsetal1999","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1101\/gad.13.5.532","article-title":"The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast","volume":"13","author":"Biggins","year":"1999","journal-title":"Genes Dev"},{"key":"2023072902201036200_Bishopetal2000","article-title":"A chemical switch for inhibitor-sensitive alleles of any protein kinase","volume":"In press","author":"Bishop","year":"2000","journal-title":"Nature"},{"key":"2023072902201036200_Booheretal1993","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.1002\/j.1460-2075.1993.tb06016.x","article-title":"Properties of Saccharomyces cerevisiae wee1 and its differential regulation of p34CDC28 in response to G1 and G2 cyclins","volume":"12","author":"Booher","year":"1993","journal-title":"EMBO (Eur. Mol. Biol. Organ.) J."},{"key":"2023072902201036200_Charlesetal1998","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0960-9822(98)70201-5","article-title":"The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae","volume":"9","author":"Charles","year":"1998","journal-title":"Curr. Biol."},{"key":"2023072902201036200_Ciosketal1998","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/S0092-8674(00)81211-8","article-title":"An ESP1\/PDS1 complex regulates loss of sister chromatid metaphase to anaphase transition in yeast","volume":"93","author":"Ciosk","year":"1998","journal-title":"Cell"},{"key":"2023072902201036200_Cohen-Fixetal1996","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1101\/gad.10.24.3081","article-title":"Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p","volume":"10","author":"Cohen-Fix","year":"1996","journal-title":"Genes Dev"},{"key":"2023072902201036200_DeBondtetal1993","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/363595a0","article-title":"Crystal structure of cyclin-dependent kinase 2","volume":"363","author":"De Bondt","year":"1993","journal-title":"Nature"},{"key":"2023072902201036200_Donovanetal1994","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1101\/gad.8.14.1640","article-title":"p40SDB25, a putative CDK inhibitor, has a role in the M\/G1 transition in Saccharomyces cerevisiae","volume":"8","author":"Donovan","year":"1994","journal-title":"Genes Dev"},{"key":"2023072902201036200_EnochandNurse1990","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/0092-8674(90)90669-6","article-title":"Mutation of fission yeast cell cycle control genes abolishes dependence of mitosis on DNA replication","volume":"60","author":"Enoch","year":"1990","journal-title":"Cell"},{"key":"2023072902201036200_Fangetal1998a","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1101\/gad.12.12.1871","article-title":"The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation","volume":"12","author":"Fang","year":"1998","journal-title":"Genes Dev"},{"key":"2023072902201036200_Fangetal1998b","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S1097-2765(00)80126-4","article-title":"Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1","volume":"2","author":"Fang","year":"1998","journal-title":"Mol. Cell"},{"key":"2023072902201036200_Felixetal1990","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/346379a0","article-title":"Triggering of cyclin degradation in interphase extracts of amphibian eggs by cdc2 kinase","volume":"346","author":"Felix","year":"1990","journal-title":"Nature"},{"key":"2023072902201036200_Fesquetetal1999","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1093\/emboj\/18.9.2424","article-title":"A Bub2p-dependent spindle checkpoint pathway regulates the Dbf2p kinase in budding yeast","volume":"18","author":"Fesquet","year":"1999","journal-title":"EMBO (Eur. Mol. Biol. Organ.) J."},{"key":"2023072902201036200_Fraschinietal1999","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1083\/jcb.145.5.979","article-title":"Budding yeast Bub2 is localized at spindle pole bodies and activates the mitotic checkpoint via a different pathway from Mad2","volume":"145","author":"Fraschini","year":"1999","journal-title":"J. Cell Biol"},{"key":"2023072902201036200_Funabikietal1996","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/381438a0","article-title":"Cut2 proteolysis required for sister-chromatid separation in fission yeast","volume":"381","author":"Funabiki","year":"1996","journal-title":"Nature"},{"key":"2023072902201036200_Funabikietal1997","doi-asserted-by":"crossref","first-page":"5977","DOI":"10.1093\/emboj\/16.19.5977","article-title":"Fission yeast Cut2 required for anaphase has two destruction boxes","volume":"16","author":"Funabiki","year":"1997","journal-title":"EMBO (Eur. Mol. Biol. Organ.) J."},{"key":"2023072902201036200_GietzandSugino1988","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/0378-1119(88)90185-0","article-title":"New yeast Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites","volume":"74","author":"Gietz","year":"1988","journal-title":"Gene"},{"key":"2023072902201036200_GouldandNurse1989","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/342039a0","article-title":"Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis","volume":"342","author":"Gould","year":"1989","journal-title":"Nature"},{"key":"2023072902201036200_GrandinandReed1993","first-page":"2113","article-title":"Differential function and expression of Saccharomyces cerevisiae B-type cyclins in mitosis and meiosis","volume":"13","author":"Grandin","year":"1993","journal-title":"Mol. Cell. Biol"},{"key":"2023072902201036200_Hadwigeretal1989","first-page":"2034","article-title":"The Saccharomyces cerevisiae CKS1 gene, a homolog of the Schizosaccharomyces pombe suc1+ gene, encodes a subunit of the Cdc28 protein kinase complex","volume":"9","author":"Hadwiger","year":"1989","journal-title":"Mol. Cell. Biol"},{"key":"2023072902201036200_Hardwick1998","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0168-9525(97)01340-1","article-title":"The spindle checkpoint","volume":"14","author":"Hardwick","year":"1998","journal-title":"Trends Genet"},{"key":"2023072902201036200_Hardwicketal1996","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1126\/science.273.5277.953","article-title":"Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption","volume":"273","author":"Hardwick","year":"1996","journal-title":"Science"},{"key":"2023072902201036200_Hardwicketal1999","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1093\/genetics\/152.2.509","article-title":"Lesions in many different spindle components activate the spindle checkpoint in the budding yeast Saccharomyces cerevisiae","volume":"152","author":"Hardwick","year":"1999","journal-title":"Genetics"},{"key":"2023072902201036200_Hardwicketal2000","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1083\/jcb.148.5.871","article-title":"MAD3 encodes a novel component of the spindle checkpoint which interacts with Bub3p and Cdc20p and Mad2p","volume":"148","author":"Hardwick","year":"2000","journal-title":"J. Cell Biol."},{"key":"2023072902201036200_Healyetal1991","first-page":"5767","article-title":"CDC55, a Saccharomyces cerevisiae gene involved in cellular morphogenesisidentification, characterization and homology to the B subunit of mammalian type 2A protein phosphatase","volume":"11","author":"Healy","year":"1991","journal-title":"Mol. Cell. Biol."},{"key":"2023072902201036200_Hershkoetal1994","doi-asserted-by":"crossref","first-page":"4940","DOI":"10.1016\/S0021-9258(17)37636-6","article-title":"Components of a system that ligates cyclin to ubiquitin and their regulation by protein kinase cdc2","volume":"269","author":"Hershko","year":"1994","journal-title":"J. Biol. Chem."},{"key":"2023072902201036200_Hollowayetal1993","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/0092-8674(93)90364-V","article-title":"Anaphase is initiated by proteolysis rather than by the inactivation of MPF","volume":"73","author":"Holloway","year":"1993","journal-title":"Cell"},{"key":"2023072902201036200_Hoytetal1991","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/0092-8674(81)90014-3","article-title":"S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function","volume":"66","author":"Hoyt","year":"1991","journal-title":"Cell"},{"key":"2023072902201036200_HwangandMurray1997","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1091\/mbc.8.10.1877","article-title":"A novel yeast screen for mitotic arrest mutants identifies DOC1, a new gene involved in cyclin proteolysis","volume":"8","author":"Hwang","year":"1997","journal-title":"Mol. Biol. Cell"},{"key":"2023072902201036200_Hwangetal1998","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1126\/science.279.5353.1041","article-title":"Budding yeast Cdc20a target of the spindle checkpoint","volume":"279","author":"Hwang","year":"1998","journal-title":"Science"},{"key":"2023072902201036200_Irnigeretal1995","first-page":"1037","article-title":"Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeast","volume":"77","author":"Irniger","year":"1995","journal-title":"Cell"},{"key":"2023072902201036200_Jaspersenetal1998","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1091\/mbc.9.10.2803","article-title":"A late mitotic regulatory network controlling cyclin destruction in Saccharomyces cerevisiae","volume":"9","author":"Jaspersen","year":"1998","journal-title":"Mol. Biol. Cell"},{"key":"2023072902201036200_Jaspersenetal1999","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0960-9822(99)80111-0","article-title":"Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14","volume":"9","author":"Jaspersen","year":"1999","journal-title":"Curr. Biol"},{"key":"2023072902201036200_Jinetal1996","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1083\/jcb.134.4.963","article-title":"Role of inhibitory CDC2 phosphorylation in radiation-induced G2 arrest in human cells","volume":"134","author":"Jin","year":"1996","journal-title":"J. Cell Biol"},{"key":"2023072902201036200_Johnstonetal1977","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0014-4827(77)90154-9","article-title":"Coordination of growth cell division in the yeast Saccharomyces cervisiae","volume":"105","author":"Johnston","year":"1977","journal-title":"Exp. Cell. Res."},{"key":"2023072902201036200_Kaiseretal1999","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1101\/gad.13.9.1190","article-title":"Cyclin-dependent kinase and Cks\/Suc1 interact with the proteasome in yeast to control proteolysis of M-phase targets","volume":"13","author":"Kaiser","year":"1999","journal-title":"Genes Dev"},{"key":"2023072902201036200_KelloggandMurray1995","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1083\/jcb.130.3.675","article-title":"NAP1 acts with Clb2 to perform mitotic functions and suppress polar bud growth in budding yeast","volume":"130","author":"Kellogg","year":"1995","journal-title":"J. Cell Biol."},{"key":"2023072902201036200_Kimetal1998","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1126\/science.279.5353.1045","article-title":"Fission yeast slp1+ encodes the effector of the Mad2-dependent spindle checkpoint","volume":"279","author":"Kim","year":"1998","journal-title":"Science"},{"key":"2023072902201036200_Kingetal1995","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0092-8674(95)90338-0","article-title":"A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B","volume":"81","author":"King","year":"1995","journal-title":"Cell"},{"key":"2023072902201036200_Kitamuraetal1998","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1091\/mbc.9.5.1065","article-title":"Fission yeast Ste9, a homolog of Hct1\/Cdh1 and Fizzy-related, is a novel negative regulator of cell cycle progression during G1-phase","volume":"9","author":"Kitamura","year":"1998","journal-title":"Mol. Biol Cell"},{"key":"2023072902201036200_Kotanietal1998","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S1097-2765(00)80037-4","article-title":"PKA and MPF-activated polo-like kinase regulate anaphase-promoting complex activity and mitosis progression","volume":"1","author":"Kotani","year":"1998","journal-title":"Mol. Cell"},{"key":"2023072902201036200_Kotanietal1999","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1083\/jcb.146.4.791","article-title":"Regulation of APC activity by phosphorylation and regulatory factors","volume":"146","author":"Kotani","year":"1999","journal-title":"J. Cell Biol"},{"key":"2023072902201036200_Krameretal1998","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/S0960-9822(07)00510-6","article-title":"Activation of the human anaphase-promoting complex by proteins of the CDC20\/Fizzy family","volume":"8","author":"Kramer","year":"1998","journal-title":"Curr. Biol"},{"key":"2023072902201036200_Lahav-Baratzetal1995","doi-asserted-by":"crossref","first-page":"9303","DOI":"10.1073\/pnas.92.20.9303","article-title":"Reversible phosphorylation controls the activity of cyclosome-associated cyclin\u2013ubiquitin ligase","volume":"92","author":"Lahav-Baratz","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023072902201036200_Lambetal1994","doi-asserted-by":"crossref","first-page":"4321","DOI":"10.1002\/j.1460-2075.1994.tb06752.x","article-title":"Cdc16p, Cdc23p and Cdc27p form a complex essential for mitosis","volume":"13","author":"Lamb","year":"1994","journal-title":"EMBO (Eur. Mol. Biol. Organ.) J."},{"key":"2023072902201036200_LewandReed1993","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1083\/jcb.120.6.1305","article-title":"Morphogenesis in the yeast cell cycleregulation by Cdc28 and cyclins","volume":"120","author":"Lew","year":"1993","journal-title":"J. Cell Biol"},{"key":"2023072902201036200_Lietal1995","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1091\/mbc.6.9.1111","article-title":"Requirement for phosphorylation of cyclin B1 for Xenopus oocyte maturation","volume":"6","author":"Li","year":"1995","journal-title":"Mol. Biol. Cell"},{"key":"2023072902201036200_Li1999","doi-asserted-by":"crossref","first-page":"4989","DOI":"10.1073\/pnas.96.9.4989","article-title":"Bifurcation of the mitotic checkpoint pathway in budding yeast","volume":"96","author":"Li","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023072902201036200_LiandMurray1991","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/0092-8674(81)90015-5","article-title":"Feedback control of mitosis in budding yeast","volume":"66","author":"Li","year":"1991","journal-title":"Cell"},{"key":"2023072902201036200_LiandCai1997","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1128\/MCB.17.5.2723","article-title":"Inactivation of the cyclin-dependent kinase Cdc28 abrogates cell cycle arrest induced by DNA damage and disassembly of mitotic spindles in Saccharomyces cerevisiae","volume":"17","author":"Li","year":"1997","journal-title":"Mol. Cell. Biol"},{"key":"2023072902201036200_Limetal1998","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0960-9822(98)70088-0","article-title":"Cdc20 is essential for the cyclosome-mediated proteolysis of both Pds1 and Clb2 during M phase in budding yeast","volume":"8","author":"Lim","year":"1998","journal-title":"Curr. Biol"},{"key":"2023072902201036200_Longtineetal1998","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1002\/(SICI)1097-0061(199807)14:10<953::AID-YEA293>3.0.CO;2-U","article-title":"Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae","volume":"14","author":"Longtine","year":"1998","journal-title":"Yeast"},{"key":"2023072902201036200_Lorcaetal1998","doi-asserted-by":"crossref","first-page":"3565","DOI":"10.1093\/emboj\/17.13.3565","article-title":"Fizzy is required for activation of the APC\/cyclosome in Xenopus egg extracts","volume":"17","author":"Lorca","year":"1998","journal-title":"EMBO (Eur. Mol. Biol. Organ.) J."},{"key":"2023072902201036200_Maniatisetal1982","volume-title":"Molecular Cloninga Laboratory Manual","author":"Maniatis","year":"1982"},{"key":"2023072902201036200_Mendenhall1993","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1126\/science.8421781","article-title":"An inhibitor of p34CDC28 protein kinase activity from Saccharomyces cerevisiae","volume":"259","author":"Mendenhall","year":"1993","journal-title":"Science"},{"key":"2023072902201036200_Minnetal1996","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1101\/gad.10.20.2621","article-title":"Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage","volume":"10","author":"Minn","year":"1996","journal-title":"Genes Dev"},{"key":"2023072902201036200_Minshulletal1994","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/0092-8674(94)90256-9","article-title":"MAP-kinase dependent mitotic feedback arrest in Xenopus egg extracts","volume":"79","author":"Minshull","year":"1994","journal-title":"Cell"},{"key":"2023072902201036200_Minshulletal1996","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/S0960-9822(02)70784-7","article-title":"Protein phosphatase 2a regulates MPF activity and sister chromatid cohesion in budding yeast","volume":"6","author":"Minshull","year":"1996","journal-title":"Curr. Biol."},{"key":"2023072902201036200_Norburyetal1991","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.1002\/j.1460-2075.1991.tb04896.x","article-title":"Regulatory phosphorylation of the p34cdc2 protein kinase in vertebrates","volume":"10","author":"Norbury","year":"1991","journal-title":"EMBO (Eur. Mol. Biol. Organ.) J."},{"key":"2023072902201036200_PatraandDunphy1996","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1101\/gad.10.12.1503","article-title":"Xe-p9, a Xenopus SUC1\/CKS homolog, has multiple essential roles in cell cycle control","volume":"10","author":"Patra","year":"1996","journal-title":"Genes Dev"},{"key":"2023072902201036200_PatraandDunphy1998","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1101\/gad.12.16.2549","article-title":"Xe-p9, a Xenopus Suc1\/Cks protein, is essential for the Cdc2-dependent phosphorylation of the anaphase-promoting complex at mitosis","volume":"12","author":"Patra","year":"1998","journal-title":"Genes Dev"},{"key":"2023072902201036200_Petersetal1996","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1126\/science.274.5290.1199","article-title":"Identification of BIME as a subunit of the anaphase-promoting complex","volume":"274","author":"Peters","year":"1996","journal-title":"Science"},{"key":"2023072902201036200_Piggottetal1982","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/298391a0","article-title":"A bifunctional gene involved in two phases of the yeast cell cycle","volume":"298","author":"Piggott","year":"1982","journal-title":"Nature"},{"key":"2023072902201036200_Prinzetal1998","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/S0960-9822(98)70298-2","article-title":"The regulation of Cdc20 proteolysis reveals a role for APC components Cdc23 and Cdc27 during S phase and early mitosis","volume":"8","author":"Prinz","year":"1998","journal-title":"Curr. Biol"},{"key":"2023072902201036200_Reed1980","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/genetics\/95.3.561","article-title":"The selection of S. cerevisiae mutants defective in the start event of cell division","volume":"95","author":"Reed","year":"1980","journal-title":"Genetics"},{"key":"2023072902201036200_Rhindetal1997","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1101\/gad.11.4.504","article-title":"Cdc2 tyrosine phosphorylation is required for the DNA damage checkpoint in fission yeast","volume":"11","author":"Rhind","year":"1997","journal-title":"Genes Dev"},{"key":"2023072902201036200_RiederandPalazzo1992","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1242\/jcs.102.3.387","article-title":"Colcemid and the mitotic cell cycle","volume":"102","author":"Rieder","year":"1992","journal-title":"J. Cell Sci."},{"key":"2023072902201036200_Riederetal1995","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1083\/jcb.130.4.941","article-title":"The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores","volume":"130","author":"Rieder","year":"1995","journal-title":"J. Cell Biol."},{"key":"2023072902201036200_RudnerandMurray1996","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0955-0674(96)80077-9","article-title":"The spindle assembly checkpoint","volume":"8","author":"Rudner","year":"1996","journal-title":"Curr. Opin. Cell Biol."},{"key":"2023072902201036200_RudnerandMurray2000","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1083\/jcb.149.7.1377","article-title":"Phosphorylation by Cdc28 activates the Cdc20-dependent activity of the anaphase-promoting complex","volume":"149","author":"Rudner","year":"2000","journal-title":"J. Cell Biol."},{"key":"2023072902201036200_Russelletal1989","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0092-8674(89)90967-7","article-title":"Conservation of mitotic controls in fission and budding yeasts","volume":"57","author":"Russell","year":"1989","journal-title":"Cell"},{"key":"2023072902201036200_Schwabetal1997","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0092-8674(00)80529-2","article-title":"Yeast Hct1 is a regulator of Clb2 cyclin proteolysis","volume":"90","author":"Schwab","year":"1997","journal-title":"Cell"},{"key":"2023072902201036200_Schwobetal1994","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0092-8674(94)90193-7","article-title":"The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae","volume":"79","author":"Schwob","year":"1994","journal-title":"Cell"},{"key":"2023072902201036200_Sethietal1991","first-page":"5592","article-title":"The CDC20 gene product of Saccharomyces cerevisiae, a b-transducin homolog, is required for a subset of microtubule-dependent cellular processes","volume":"11","author":"Sethi","year":"1991","journal-title":"Mol. Cell. Biol"},{"key":"2023072902201036200_Shermanetal1974","volume-title":"Methods in Yeast Genetics","author":"Sherman","year":"1974"},{"key":"2023072902201036200_Shirayamaetal1998","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1093\/emboj\/17.5.1336","article-title":"The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p\/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae","volume":"17","author":"Shirayama","year":"1998","journal-title":"EMBO (Eur. Mol. Biol. Organ.) J."},{"key":"2023072902201036200_Shirayamaetal1999","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/46080","article-title":"APCCdc20 promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5","volume":"402","author":"Shirayama","year":"1999","journal-title":"Nature"},{"key":"2023072902201036200_ShteinbergandHershko1999","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1006\/bbrc.1999.0409","article-title":"Role of Suc1 in the activation of the cyclosome by protein kinase Cdk1\/cyclin B","volume":"257","author":"Shteinberg","year":"1999","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"2023072902201036200_Shteinbergetal1999","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1006\/bbrc.1999.0884","article-title":"Phosphorylation of the cyclosome is required for its stimulation by Fizzy\/cdc20","volume":"260","author":"Shteinberg","year":"1999","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"2023072902201036200_SigristandLehner1997","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0092-8674(00)80528-0","article-title":"Drosophila fizzy-related down-regulates mitotic cyclins and is required for cell proliferation arrest and entry into endocycles","volume":"90","author":"Sigrist","year":"1997","journal-title":"Cell"},{"key":"2023072902201036200_Sigristetal1995","doi-asserted-by":"crossref","first-page":"4827","DOI":"10.1002\/j.1460-2075.1995.tb00164.x","article-title":"Exit from mitosis is regulated by Drosophila fizzy and the sequential destruction of cyclins A, B and B3","volume":"14","author":"Sigrist","year":"1995","journal-title":"EMBO (Eur. Mol. Biol. Organ.) J"},{"key":"2023072902201036200_SikorskiandHieter1989","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/genetics\/122.1.19","article-title":"A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae","volume":"122","author":"Sikorski","year":"1989","journal-title":"Genetics"},{"key":"2023072902201036200_SorgerandMurray1992","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/355365a0","article-title":"S-phase feedback control in budding yeast independent of tyrosine phosphorylation of p34CDC28","volume":"355","author":"Sorger","year":"1992","journal-title":"Nature"},{"key":"2023072902201036200_Straightetal1996","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/S0960-9822(02)70783-5","article-title":"GFP tagging of budding yeast chromosomes reveals that protein\u2013protein interactions can mediate sister chromatid cohesion","volume":"6","author":"Straight","year":"1996","journal-title":"Curr. Biol."},{"key":"2023072902201036200_Stuelandetal1993","first-page":"3744","article-title":"Full activation of p34CDC28 histone H1 kinase activity is unable to promote entry into mitosis in checkpoint-arrested cells of the yeast Saccharomyces cerevisiae","volume":"13","author":"Stueland","year":"1993","journal-title":"Mol. Cell. Biol"},{"key":"2023072902201036200_Sudakinetal1995","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1091\/mbc.6.2.185","article-title":"The cyclosome, a large complex containing cyclin-selective ubiquitination ligase activity, targets cyclins for destruction at the end of mitosis","volume":"6","author":"Sudakin","year":"1995","journal-title":"Mol. Biol. Cell"},{"key":"2023072902201036200_Suranaetal1991","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0092-8674(91)90416-V","article-title":"The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiae","volume":"65","author":"Surana","year":"1991","journal-title":"Cell"},{"key":"2023072902201036200_Suranaetal1993","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1002\/j.1460-2075.1993.tb05846.x","article-title":"Destruction of the CDC28\/CLB mitotic kinase is not required for the metaphase to anaphase transition in budding yeast","volume":"12","author":"Surana","year":"1993","journal-title":"EMBO (Eur. Mol. Biol. Organ.) J."},{"key":"2023072902201036200_TangandReed1993","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1101\/gad.7.5.822","article-title":"The Cdk-associated protein Cks1 functions both in G1 and G2 in Saccharomyces cerevisiae","volume":"7","author":"Tang","year":"1993","journal-title":"Genes Dev"},{"key":"2023072902201036200_Tinker-KulbergandMorgan1999","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1101\/gad.13.15.1936","article-title":"Pds1 and Esp1 control both anaphase and mitotic exit in normal cells and after DNA damage","volume":"13","author":"Tinker-Kulberg","year":"1999","journal-title":"Genes Dev"},{"key":"2023072902201036200_Toczyskietal1997","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/S0092-8674(00)80375-X","article-title":"CDC5 and CKII control adaptation to the yeast DNA damage checkpoint","volume":"90","author":"Toczyski","year":"1997","journal-title":"Cell"},{"key":"2023072902201036200_Toynetal1997","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/genetics\/145.1.85","article-title":"The Swi5 transcription factor of Saccharomyces cerevisiae has a role in exit from mitosis through induction of the cdk-inhibitor Sic1 in telophase","volume":"145","author":"Toyn","year":"1997","journal-title":"Genetics"},{"key":"2023072902201036200_Visintinetal1997","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1126\/science.278.5337.460","article-title":"CDC20 and CDH1A family of substrate-specific activators of APC-dependent proteolysis","volume":"278","author":"Visintin","year":"1997","journal-title":"Science"},{"key":"2023072902201036200_Visintinetal1998","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S1097-2765(00)80286-5","article-title":"The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation","volume":"2","author":"Visintin","year":"1998","journal-title":"Mol. Cell"},{"key":"2023072902201036200_WangandBurke1997","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1128\/MCB.17.2.620","article-title":"Cdc55p, the B-type regulatory subunit of protein phosphatase 2A, has multiple functions in mitosis and is required for the kinetochore\/spindle checkpoint in Saccharomyces cerevisiae","volume":"17","author":"Wang","year":"1997","journal-title":"Mol. Cell. Biol"},{"key":"2023072902201036200_WeissandWiney1996","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1083\/jcb.132.1.111","article-title":"The S. cerevisiae SPB duplication gene MPS1 is part of a mitotic checkpoint","volume":"132","author":"Weiss","year":"1996","journal-title":"J. Cell Biol."},{"key":"2023072902201036200_WellsandMurray1996","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1083\/jcb.133.1.75","article-title":"Aberrantly segregating centromeres activate the spindle assembly checkpoint in budding yeast","volume":"133","author":"Wells","year":"1996","journal-title":"J. Cell Biol."},{"key":"2023072902201036200_Yamaguchietal1997","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1091\/mbc.8.12.2475","article-title":"A WD repeat protein controls the cell cycle and differentiation by negatively regulating Cdc2\/B-type cyclin complexes","volume":"8","author":"Yamaguchi","year":"1997","journal-title":"Mol. Biol. Cell"},{"key":"2023072902201036200_Yanagidaetal1999","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1098\/rstb.1999.0499","article-title":"Control of metaphase\u2013anaphase progression by proteolysiscyclosome function regulated by the protein kinase A pathway, ubiquitination, and localization","volume":"354","author":"Yanagida","year":"1999","journal-title":"Philos. Trans. R. Soc. Lond. Biol. Sci"},{"key":"2023072902201036200_Yeongetal2000","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S1097-2765(00)80444-X","article-title":"Exit from mitosis in budding yeastbiphasic inactivation of the Cdc28\u2013Clb2 mitotic kinase and the role of Cdc20","volume":"5","author":"Yeong","year":"2000","journal-title":"Mol. Cell"},{"key":"2023072902201036200_ZachariaeandNasmyth1996","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1091\/mbc.7.5.791","article-title":"TPR proteins required for anaphase progression mediate ubiquitination of mitotic B type cyclins in yeast","volume":"7","author":"Zachariae","year":"1996","journal-title":"Mol. Biol. Cell"},{"key":"2023072902201036200_ZachariaeandNasmyth1999","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1101\/gad.13.16.2039","article-title":"Whose end is destructioncell division and the anaphase-promoting complex","volume":"13","author":"Zachariae","year":"1999","journal-title":"Genes Dev"},{"key":"2023072902201036200_Zachariaeetal1998","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1126\/science.282.5394.1721","article-title":"Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the anaphase promoting complex","volume":"282","author":"Zachariae","year":"1998","journal-title":"Science"}],"container-title":["The Journal of Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/149\/7\/1361\/1859030\/0003149.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/149\/7\/1361\/1859030\/0003149.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,29]],"date-time":"2023-07-29T02:21:48Z","timestamp":1690597308000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jcb\/article\/149\/7\/1361\/32039\/Cdc28-Activates-Exit-from-Mitosis-in-Budding-Yeast"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,6,26]]},"references-count":106,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2000,6,26]]}},"URL":"https:\/\/doi.org\/10.1083\/jcb.149.7.1361","relation":{},"ISSN":["0021-9525","1540-8140"],"issn-type":[{"value":"0021-9525","type":"print"},{"value":"1540-8140","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,6,26]]}}}