{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T08:37:10Z","timestamp":1771663030511,"version":"3.50.1"},"reference-count":68,"publisher":"Rockefeller University Press","issue":"6","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2000,9,18]]},"abstract":"<jats:p>Cell\u2013cell and cell\u2013matrix interactions play a critical role in tissue morphogenesis and in homeostasis of adult tissues. The integrin family of adhesion receptors regulates cellular interactions with the extracellular matrix, which provides three-dimensional information for tissue organization. It is currently thought that pancreatic islet cells develop from undifferentiated progenitors residing within the ductal epithelium of the fetal pancreas. This process involves cell budding from the duct, migration into the surrounding mesenchyme, differentiation, and clustering into the highly organized islet of Langerhans. Here we report that \u03b1v\u03b23 and \u03b1v\u03b25, two integrins known to coordinate epithelial cell adhesion and movement, are expressed in pancreatic ductal cells and clusters of undifferentiated cells emerging from the ductal epithelium. We show that expression and function of \u03b1v\u03b23 and \u03b1v\u03b25 integrins are developmentally regulated during pancreatic islet ontogeny, and mediate adhesion and migration of putative endocrine progenitor cells both in vitro and in vivo in a model of pancreatic islet development. Moreover, we demonstrate the expression of fibronectin and collagen IV in the basal membrane of pancreatic ducts and of cell clusters budding from the ductal epithelium. Conversely, expression of vitronectin marks a population of epithelial cells adjacent to, or emerging from, pancreatic ducts. Thus, these data provide the first evidence for the contribution of integrins \u03b1v\u03b23 and \u03b1v\u03b25 and their ligands to morphogenetic events in the human endocrine pancreas.<\/jats:p>","DOI":"10.1083\/jcb.150.6.1445","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:45:41Z","timestamp":1027701941000},"page":"1445-1460","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":147,"title":["Expression and Function of \u03b1v\u03b23 and \u03b1v\u03b25 Integrins in the Developing Pancreas"],"prefix":"10.1083","volume":"150","author":[{"given":"Vincenzo","family":"Cirulli","sequence":"first","affiliation":[{"name":"aThe Islet Research Laboratory at The Whittier Institute for Diabetes, Department of Pediatrics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gillian M.","family":"Beattie","sequence":"additional","affiliation":[{"name":"aThe Islet Research Laboratory at The Whittier Institute for Diabetes, Department of Pediatrics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Klier","sequence":"additional","affiliation":[{"name":"dDepartment of Cell Biology, The Scripps Research Institute, La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Ellisman","sequence":"additional","affiliation":[{"name":"bThe National Center for Microscopy and Imaging Research, University of California San Diego, La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camillo","family":"Ricordi","sequence":"additional","affiliation":[{"name":"cThe Diabetes Research Institute, University of Miami School of Medicine, Miami, Florida 33136"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vito","family":"Quaranta","sequence":"additional","affiliation":[{"name":"dDepartment of Cell Biology, The Scripps Research Institute, La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francine","family":"Frasier","sequence":"additional","affiliation":[{"name":"dDepartment of Cell Biology, The Scripps Research Institute, La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer K.","family":"Ishii","sequence":"additional","affiliation":[{"name":"eDepartment of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Hayek","sequence":"additional","affiliation":[{"name":"aThe Islet Research Laboratory at The Whittier Institute for Diabetes, Department of Pediatrics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel R.","family":"Salomon","sequence":"additional","affiliation":[{"name":"eDepartment of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[2000,9,18]]},"reference":[{"key":"2023072902264053900_Alpertetal1988","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0092-8674(88)90391-1","article-title":"Hybrid insulin gene reveal a developmental lineage for pancreatic endocrine cell and imply a relationship with neurons","volume":"53","author":"Alpert","year":"1988","journal-title":"Cell."},{"key":"2023072902264053900_N0x2f47b40N0x3e508c8","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1242\/jcs.103.4.1235","article-title":"Cadherin-mediated adhesion in pancreatic islet cells is modulated by a cell surface N-acetylgalactosaminylphosphotransferase","volume":"103","author":"Bauer","year":"1992","journal-title":"J. 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Anat."},{"key":"2023072902264053900_WattandJones1993","first-page":"185","article-title":"Expression and function of keratinocyte integrins","volume":"106","author":"Watt","year":"1993","journal-title":"Development Suppl."}],"container-title":["The Journal of Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/150\/6\/1445\/1859780\/0005108.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/150\/6\/1445\/1859780\/0005108.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,29]],"date-time":"2023-07-29T02:28:21Z","timestamp":1690597701000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jcb\/article\/150\/6\/1445\/45489\/Expression-and-Function-of-v-3-and-v-5-Integrins"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9,18]]},"references-count":68,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2000,9,18]]}},"URL":"https:\/\/doi.org\/10.1083\/jcb.150.6.1445","relation":{},"ISSN":["0021-9525","1540-8140"],"issn-type":[{"value":"0021-9525","type":"print"},{"value":"1540-8140","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,9,18]]}}}