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Together, these results reveal that agents or stresses that induce global changes in chromatin topology during G2 delay entry into mitosis, independent of the ATM-mediated DNA damage checkpoint, by activating the p38 MAPK checkpoint. The presence of this pathway obviates the necessity of postulating the existence of multiple \u201cchromatin modification\u201d checkpoints during G2. Lastly, cells that enter mitosis in the presence of topo II inhibitors form metaphase spindles that are delayed in entering anaphase via the spindle assembly, and not the p38, checkpoint.<\/jats:p>","DOI":"10.1083\/jcb.200405167","type":"journal-article","created":{"date-parts":[[2004,8,9]],"date-time":"2004-08-09T20:13:25Z","timestamp":1092082405000},"page":"517-526","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":112,"title":["Topoisomerase II and histone deacetylase inhibitors delay the G2\/M transition by triggering the p38 MAPK checkpoint pathway"],"prefix":"10.1083","volume":"166","author":[{"given":"Alexei","family":"Mikhailov","sequence":"first","affiliation":[{"name":"1Division of Molecular Medicine, Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12201"}]},{"given":"Mio","family":"Shinohara","sequence":"additional","affiliation":[{"name":"1Division of Molecular Medicine, Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12201"},{"name":"2Department of Biomedical Sciences, State University of New York, Albany, NY 12222"}]},{"given":"Conly L.","family":"Rieder","sequence":"additional","affiliation":[{"name":"1Division of Molecular Medicine, Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12201"},{"name":"2Department of Biomedical Sciences, State University of New York, Albany, NY 12222"},{"name":"3Marine Biology Laboratory, Woods Hole, MA 02543"}]}],"member":"291","published-online":{"date-parts":[[2004,8,9]]},"reference":[{"key":"2023072218191873900_BIB1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nature01368","volume":"421","year":"2003","journal-title":"Nature."},{"key":"2023072218191873900_BIB2","doi-asserted-by":"crossref","first-page":"13681","DOI":"10.1073\/pnas.251194298","volume":"98","year":"2001","journal-title":"Proc. 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