{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T20:34:58Z","timestamp":1779222898860,"version":"3.51.4"},"reference-count":58,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2005,8,1]]},"abstract":"<jats:p>Target genes of the protooncogene c-myc are implicated in cell cycle and growth control, yet the linkage of both is still unexplored. Here, we show that the products of the nucleolar target genes Pes1 and Bop1 form a stable complex with a novel member, WDR12 (PeBoW complex). Endogenous WDR12, a WD40 repeat protein, is crucial for processing of the 32S precursor ribosomal RNA (rRNA) and cell proliferation. Further, a conditionally expressed dominant-negative mutant of WDR12 also blocks rRNA processing and induces a reversible cell cycle arrest. Mutant WDR12 triggers accumulation of p53 in a p19ARF-independent manner in proliferating cells but not in quiescent cells. Interestingly, a potential homologous complex of Pes1\u2013Bop1\u2013WDR12 in yeast (Nop7p\u2013Erb1p\u2013Ytm1p) is involved in the control of ribosome biogenesis and S phase entry. In conclusion, the integrity of the PeBoW complex is required for ribosome biogenesis and cell proliferation in mammalian cells.<\/jats:p>","DOI":"10.1083\/jcb.200501141","type":"journal-article","created":{"date-parts":[[2005,7,26]],"date-time":"2005-07-26T00:35:45Z","timestamp":1122338145000},"page":"367-378","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":164,"title":["Mammalian WDR12 is a novel member of the Pes1\u2013Bop1 complex and is required for ribosome biogenesis and cell proliferation"],"prefix":"10.1083","volume":"170","author":[{"given":"Michael","family":"Ho\u0308lzel","sequence":"first","affiliation":[{"name":"1Institute of Clinical Molecular Biology and Tumour Genetics, National Research Center for Environment and Health (GSF), 81377 Munich, Germany"},{"name":"4Department of Internal Medicine III, University Hospital Grosshadern, Ludwig-Maximilians-University, 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela","family":"Rohrmoser","sequence":"additional","affiliation":[{"name":"1Institute of Clinical Molecular Biology and Tumour Genetics, National Research Center for Environment and Health (GSF), 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Schlee","sequence":"additional","affiliation":[{"name":"1Institute of Clinical Molecular Biology and Tumour Genetics, National Research Center for Environment and Health (GSF), 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Grimm","sequence":"additional","affiliation":[{"name":"1Institute of Clinical Molecular Biology and Tumour Genetics, National Research Center for Environment and Health (GSF), 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Harasim","sequence":"additional","affiliation":[{"name":"1Institute of Clinical Molecular Biology and Tumour Genetics, National Research Center for Environment and Health (GSF), 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastassia","family":"Malamoussi","sequence":"additional","affiliation":[{"name":"1Institute of Clinical Molecular Biology and Tumour Genetics, National Research Center for Environment and Health (GSF), 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Gruber-Eber","sequence":"additional","affiliation":[{"name":"1Institute of Clinical Molecular Biology and Tumour Genetics, National Research Center for Environment and Health (GSF), 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Kremmer","sequence":"additional","affiliation":[{"name":"2Institute of Molecular Immunology, National Research Center for Environment and Health (GSF), 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Hiddemann","sequence":"additional","affiliation":[{"name":"3Clinical Cooperative Group Acute Leukemia, National Research Center for Environment and Health (GSF), 81377 Munich, Germany"},{"name":"4Department of Internal Medicine III, University Hospital Grosshadern, Ludwig-Maximilians-University, 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg W.","family":"Bornkamm","sequence":"additional","affiliation":[{"name":"1Institute of Clinical Molecular Biology and Tumour Genetics, National Research Center for Environment and Health (GSF), 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Eick","sequence":"additional","affiliation":[{"name":"1Institute of Clinical Molecular Biology and Tumour Genetics, National Research Center for Environment and Health (GSF), 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[2005,7,25]]},"reference":[{"key":"2023072217322869900_BIB1","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1038\/sj.emboj.7600247","volume":"23","year":"2004","journal-title":"EMBO J."},{"key":"2023072217322869900_BIB2","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/35023500","volume":"2","year":"2000","journal-title":"Nat. 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