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Both BLM and 53BP1 abrogate endogenous RAD51 foci formation and disrupt RAD51 polymerization. Consequently, loss of BLM and 53BP1 synergistically enhances stress-dependent homologous recombination. These results provide evidence regarding the cooperation between BLM and 53BP1 during maintenance of genomic integrity.<\/jats:p>","DOI":"10.1083\/jcb.200610051","type":"journal-article","created":{"date-parts":[[2007,6,26]],"date-time":"2007-06-26T00:53:54Z","timestamp":1182819234000},"page":"9-14","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":48,"title":["BLM helicase\u2013dependent and \u2013independent roles of 53BP1 during replication stress\u2013mediated homologous recombination"],"prefix":"10.1083","volume":"178","author":[{"given":"Vivek","family":"Tripathi","sequence":"first","affiliation":[{"name":"National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tirunelvely","family":"Nagarjuna","sequence":"additional","affiliation":[{"name":"National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sagar","family":"Sengupta","sequence":"additional","affiliation":[{"name":"National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2007,6,25]]},"reference":[{"key":"2023072908542090700_BIB1","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.4161\/cc.4.12.2282","volume":"4","year":"2005","journal-title":"Cell Cycle."},{"key":"2023072908542090700_BIB2","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1083\/jcb.200503043","volume":"170","year":"2005","journal-title":"J. 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