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This apoptosis was preceded by depletion of the Krebs cycle intermediates, was prevented by two Krebs cycle substrates, but was unrelated to ATP synthesis or several other reported consequences of glutamine starvation. Our results suggest that the fate of normal human cells should be considered in evaluating nutrient deprivation as a strategy for cancer therapy, and that understanding how glutamine metabolism is linked to cell viability might provide new approaches for treatment of cancer.<\/jats:p>","DOI":"10.1083\/jcb.200703099","type":"journal-article","created":{"date-parts":[[2007,7,2]],"date-time":"2007-07-02T22:58:00Z","timestamp":1183417080000},"page":"93-105","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":584,"title":["Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells"],"prefix":"10.1083","volume":"178","author":[{"given":"Mariia","family":"Yuneva","sequence":"first","affiliation":[{"name":"1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724"},{"name":"2G.W. 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