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Mice deficient in the Src family tyrosine kinase Fyn are hypomyelinated and contain reduced levels of MBP. Here, we identify hnRNP A2 as a target of activated Fyn in oligodendrocytes. We show that active Fyn phosphorylates hnRNP A2 and stimulates translation of an MBP A2RE\u2013containing reporter construct. Neuronal adhesion molecule L1 binding to oligodendrocytes results in Fyn activation, which leads to an increase in hnRNP A2 phosphorylation. These results suggest that Fyn kinase activation results in the localized translation of MBP mRNA at sites of axon\u2013glia contact and myelin deposition.<\/jats:p>","DOI":"10.1083\/jcb.200706164","type":"journal-article","created":{"date-parts":[[2008,5,19]],"date-time":"2008-05-19T15:23:11Z","timestamp":1211210591000},"page":"579-586","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":174,"title":["Activation of oligodendroglial Fyn kinase enhances translation of mRNAs transported in hnRNP A2\u2013dependent RNA granules"],"prefix":"10.1083","volume":"181","author":[{"given":"Robin","family":"White","sequence":"first","affiliation":[{"name":"1Molecular Cell Biology, Department of Biology, Johannes Gutenberg University of Mainz, 55128 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantin","family":"Gonsior","sequence":"additional","affiliation":[{"name":"1Molecular Cell Biology, Department of Biology, Johannes Gutenberg University of Mainz, 55128 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva-Maria","family":"Kra\u0308mer-Albers","sequence":"additional","affiliation":[{"name":"1Molecular Cell Biology, Department of Biology, Johannes Gutenberg University of Mainz, 55128 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Sto\u0308hr","sequence":"additional","affiliation":[{"name":"2NBL3 Research Group, Zentrum fu\u0308r Angewandte Medizinische und Human-biologische Forschung, Department of Medicine, Martin-Luther-University, 06120 Halle, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Hu\u0308ttelmaier","sequence":"additional","affiliation":[{"name":"2NBL3 Research Group, Zentrum fu\u0308r Angewandte Medizinische und Human-biologische Forschung, Department of Medicine, Martin-Luther-University, 06120 Halle, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Trotter","sequence":"additional","affiliation":[{"name":"1Molecular Cell Biology, Department of Biology, Johannes Gutenberg University of Mainz, 55128 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2008,5,19]]},"reference":[{"key":"2023072909554524600_BIB1","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1083\/jcb.138.5.1077","volume":"138","year":"1997","journal-title":"J. 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