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By replacing the mouse \u03b1-globin gene cluster in situ with its human counterpart, we demonstrate a direct effect of the regional chromatin environment on the frequency of association, whereas nascent transcription from the human \u03b1-globin gene appears unaffected. We see no evidence that cotranscribed erythroid genes associate at shared transcription foci, but we do see stochastic clustering of active genes around common nuclear SC35-enriched speckles (hence the apparent nonrandom association between genes). Thus, association between active genes may result from their location on decondensed chromatin that enables clustering around common nuclear speckles.<\/jats:p>","DOI":"10.1083\/jcb.200803174","type":"journal-article","created":{"date-parts":[[2008,9,22]],"date-time":"2008-09-22T13:53:21Z","timestamp":1222091601000},"page":"1083-1097","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":237,"title":["Association between active genes occurs at nuclear speckles and is modulated by chromatin environment"],"prefix":"10.1083","volume":"182","author":[{"given":"Jill M.","family":"Brown","sequence":"first","affiliation":[{"name":"1Medical Research Council Molecular Haematology Unit"}]},{"given":"Joanne","family":"Green","sequence":"additional","affiliation":[{"name":"1Medical Research Council Molecular Haematology Unit"}]},{"given":"Ricardo Pires","family":"das Neves","sequence":"additional","affiliation":[{"name":"1Medical Research Council Molecular Haematology Unit"}]},{"given":"Helen A.C.","family":"Wallace","sequence":"additional","affiliation":[{"name":"3Institute for Stem Cell Research, University of Edinburgh, Edinburgh EH9 3JQ, Scotland, UK"}]},{"given":"Andrew J.H.","family":"Smith","sequence":"additional","affiliation":[{"name":"3Institute for Stem Cell Research, University of Edinburgh, Edinburgh EH9 3JQ, Scotland, UK"}]},{"given":"Jim","family":"Hughes","sequence":"additional","affiliation":[{"name":"1Medical Research Council Molecular Haematology Unit"}]},{"given":"Nicki","family":"Gray","sequence":"additional","affiliation":[{"name":"1Medical Research Council Molecular Haematology Unit"}]},{"given":"Steve","family":"Taylor","sequence":"additional","affiliation":[{"name":"2Computational Biology Research Group, Weatherall Institute of Molecular Medicine, Oxford University, Oxford OX3 9DS, England, UK"}]},{"given":"William G.","family":"Wood","sequence":"additional","affiliation":[{"name":"1Medical Research Council Molecular Haematology Unit"}]},{"given":"Douglas R.","family":"Higgs","sequence":"additional","affiliation":[{"name":"1Medical Research Council Molecular Haematology Unit"}]},{"given":"Francisco J.","family":"Iborra","sequence":"additional","affiliation":[{"name":"1Medical Research Council Molecular Haematology Unit"}]},{"given":"Veronica J.","family":"Buckle","sequence":"additional","affiliation":[{"name":"1Medical Research Council Molecular Haematology Unit"}]}],"member":"291","published-online":{"date-parts":[[2008,9,22]]},"reference":[{"key":"2023072223504935200_BIB1","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1126\/science.1149420","volume":"318","year":"2007","journal-title":"Science."},{"key":"2023072223504935200_BIB2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/ncb1365","volume":"8","year":"2006","journal-title":"Nat. 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