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This nucleosome destabilization is an active process requiring the ATPase activity of the p400 SWI\/SNF ATPase and histone acetylation by the Tip60 acetyltransferase. p400 is recruited to DSBs by a mechanism that is independent of ATM but requires mdc1. Further, the destabilization of nucleosomes by p400 is required for the RNF8-dependent ubiquitination of chromatin, and for the subsequent recruitment of brca1 and 53BP1 to DSBs. These results identify p400 as a novel DNA damage response protein and demonstrate that p400-mediated alterations in nucleosome and chromatin structure promote both chromatin ubiquitination and the accumulation of brca1 and 53BP1 at sites of DNA damage.<\/jats:p>","DOI":"10.1083\/jcb.201001160","type":"journal-article","created":{"date-parts":[[2010,9,28]],"date-time":"2010-09-28T00:15:32Z","timestamp":1285632932000},"page":"31-43","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":161,"title":["The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair"],"prefix":"10.1083","volume":"191","author":[{"given":"Ye","family":"Xu","sequence":"first","affiliation":[{"name":"Division of Genomic Stability and DNA Repair, Department of Radiation Oncology 1 , and 2"},{"name":"Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115 1 , and 2"}]},{"given":"Yingli","family":"Sun","sequence":"additional","affiliation":[{"name":"Division of Genomic Stability and DNA Repair, Department of Radiation Oncology 1 , and 2"},{"name":"Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115 1 , and 2"}]},{"given":"Xiaofeng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Division of Genomic Stability and DNA Repair, Department of Radiation Oncology 1 , and 2"},{"name":"Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115 1 , and 2"}]},{"given":"Marina K.","family":"Ayrapetov","sequence":"additional","affiliation":[{"name":"Division of Genomic Stability and DNA Repair, Department of Radiation Oncology 1 , and 2"},{"name":"Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115 1 , and 2"}]},{"given":"Patryk","family":"Moskwa","sequence":"additional","affiliation":[{"name":"Division of Genomic Stability and DNA Repair, Department of Radiation Oncology 1 , and 2"},{"name":"Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115 1 , and 2"}]},{"given":"Shenghong","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Genomic Stability and DNA Repair, Department of Radiation Oncology 1 , and 2"},{"name":"Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115 1 , and 2"}]},{"given":"David M.","family":"Weinstock","sequence":"additional","affiliation":[{"name":"Division of Genomic Stability and DNA Repair, Department of Radiation Oncology 1 , and 2"},{"name":"Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115 1 , and 2"}]},{"given":"Brendan D.","family":"Price","sequence":"additional","affiliation":[{"name":"Division of Genomic Stability and DNA Repair, Department of Radiation Oncology 1 , and 2"},{"name":"Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115 1 , and 2"}]}],"member":"291","published-online":{"date-parts":[[2010,9,27]]},"reference":[{"key":"2023072300214714700_bib1","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/nature01035","article-title":"Acetylation of histone H4 by Esa1 is required for DNA double-strand break repair","volume":"419","author":"Bird","year":"2002","journal-title":"Nature."},{"key":"2023072300214714700_bib2","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1038\/nrc2523","article-title":"GammaH2AX and cancer","volume":"8","author":"Bonner","year":"2008","journal-title":"Nat. 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