{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T19:34:53Z","timestamp":1791056093717,"version":"4.1.0"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"6","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1989,6,1]]},"abstract":"<jats:p>Despite extensive efforts, little progress has been made in identifying the factors that induce hepatic fibrosis. Transforming growth factor-beta (TGF-beta) has been shown to enhance collagen production, therefore its role in hepatic fibrosis was investigated. Treatment of cultured hepatic cells with TGF-beta 1 increased type I procollagen mRNA levels 13-fold due to post-transcriptional gene regulation. When two animal models of hepatic fibrosis, murine schistosomiasis and CCl4-treated rats, were examined, they both exhibited increased levels of TGF-beta 1 gene expression at times that somewhat preceded the increase in collagen synthesis. In contrast, in murine schistosomiasis, mRNA levels of tumor necrosis factor and interleukin-1 peaked early in the fibrogenic process. Immunohistochemical analysis showed TGF-beta 1 to be present in normal mouse liver and to be markedly increased in mice infected with schistosomiasis. TGF-beta 1 appeared in the hepatic parenchyma, primarily in hepatocytes. These findings strongly suggest a role for TGF-beta 1 in a pathophysiological state.<\/jats:p>","DOI":"10.1083\/jcb.108.6.2477","type":"journal-article","created":{"date-parts":[[2004,5,15]],"date-time":"2004-05-15T00:18:20Z","timestamp":1084580300000},"page":"2477-2482","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":320,"title":["In vitro and in vivo association of transforming growth factor-beta 1 with hepatic fibrosis."],"prefix":"10.1083","volume":"108","author":[{"given":"M J","family":"Czaja","sequence":"first","affiliation":[{"name":"Albert Einstein College of Medicine, Marion Bessin Liver Research Center, Bronx, New York 10461."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F R","family":"Weiner","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine, Marion Bessin Liver Research Center, Bronx, New York 10461."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K C","family":"Flanders","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine, Marion Bessin Liver Research Center, Bronx, New York 10461."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M A","family":"Giambrone","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine, Marion Bessin Liver Research Center, Bronx, New York 10461."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Wind","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine, Marion Bessin Liver Research Center, Bronx, New York 10461."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Biempica","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine, Marion Bessin Liver Research Center, Bronx, New York 10461."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M A","family":"Zern","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine, Marion Bessin Liver Research Center, Bronx, New York 10461."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1989,6,1]]},"container-title":["The Journal of cell biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/108\/6\/2477\/1462017\/2477.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/108\/6\/2477\/1462017\/2477.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,22]],"date-time":"2023-07-22T00:45:04Z","timestamp":1689986704000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jcb\/article\/108\/6\/2477\/55636\/In-vitro-and-in-vivo-association-of-transforming"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1989,6,1]]}},"URL":"https:\/\/doi.org\/10.1083\/jcb.108.6.2477","relation":{},"ISSN":["0021-9525","1540-8140"],"issn-type":[{"value":"0021-9525","type":"print"},{"value":"1540-8140","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,6,1]]}}}