{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:14:28Z","timestamp":1791080068705,"version":"4.1.0"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1995,5,15]]},"abstract":"<jats:p>Caenorhabditis elegans unc-44 mutations result in aberrant axon guidance and fasciculation with inappropriate partners. The unc-44 gene was cloned by transposon tagging, and verified by genetic and molecular analyses of six transposon-induced alleles and their revertants. Nucleotide sequence analyses demonstrated that unc-44 encodes a series of putative ankyrin-related proteins, including AO49 ankyrin (1815 aa, 198.8 kD), AO66 ankyrin (1867 aa, 204 kD), and AO13 ankyrin (&amp;lt; or = 4700 aa, &amp;lt; or = 517 kD). In addition to the major set of approximately 6 kb alternatively spliced transcripts, minor transcripts were observed at approximately 3, 5, 7, and 14 kb. Evidence is provided that mutations in the approximately 14-kb AO13 ankyrin transcript are responsible for the neuronal defects. These molecular studies provide the first evidence that ankyrin-related molecules are required for axonal guidance.<\/jats:p>","DOI":"10.1083\/jcb.129.4.1081","type":"journal-article","created":{"date-parts":[[2004,5,15]],"date-time":"2004-05-15T01:23:47Z","timestamp":1084584227000},"page":"1081-1092","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":96,"title":["An ankyrin-related gene (unc-44) is necessary for proper axonal guidance in Caenorhabditis elegans."],"prefix":"10.1083","volume":"129","author":[{"given":"A J","family":"Otsuka","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Illinois State University, Normal 61790-4120, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Franco","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Illinois State University, Normal 61790-4120, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Illinois State University, Normal 61790-4120, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K H","family":"Shim","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Illinois State University, Normal 61790-4120, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L Z","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Illinois State University, Normal 61790-4120, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y Y","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Illinois State University, Normal 61790-4120, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Boontrakulpoontawee","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Illinois State University, Normal 61790-4120, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Jeyaprakash","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Illinois State University, Normal 61790-4120, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Hedgecock","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Illinois State University, Normal 61790-4120, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V I","family":"Wheaton","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Illinois State University, Normal 61790-4120, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1995,5,15]]},"container-title":["The Journal of cell biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/129\/4\/1081\/1479162\/1081.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/129\/4\/1081\/1479162\/1081.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,22]],"date-time":"2023-07-22T06:03:51Z","timestamp":1690005831000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jcb\/article\/129\/4\/1081\/20788\/An-ankyrin-related-gene-unc-44-is-necessary-for"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,5,15]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1995,5,15]]}},"URL":"https:\/\/doi.org\/10.1083\/jcb.129.4.1081","relation":{},"ISSN":["0021-9525","1540-8140"],"issn-type":[{"value":"0021-9525","type":"print"},{"value":"1540-8140","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,5,15]]}}}