{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:59:13Z","timestamp":1791946753386,"version":"4.3.4"},"reference-count":53,"publisher":"Rockefeller University Press","issue":"1","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1997,7,14]]},"abstract":"<jats:p>Cell adhesion molecules of the Ig superfamily are implicated in a wide variety of biological processes, including cell migration, axon guidance and fasciculation, and growth control and tumorigenesis. Expression of these proteins can be highly dynamic and cell type specific, but little is known of the signals that regulate such specificity. Reported here is the molecular cloning and characterization of rat CDO, a novel cell surface glycoprotein of the Ig superfamily that contains five Ig-like repeats, followed by three fibronectin type III\u2013like repeats in its extracellular region, and a 256-amino acid intracellular region that does not resemble other known proteins. In rat embryo fibroblasts, cdo mRNA expression is maximal in confluent, quiescent cells. It is rapidly and transiently down-regulated by serum stimulation of such cells, and is constitutively down-regulated in oncogene-transformed derivatives of these cells. CDO protein levels are also dramatically regulated by cell\u2013substratum adhesion, via a mechanism that is independent of cdo mRNA expression. The amount of CDO produced at the surface of a cell may therefore be governed by a complex balance of signals, including mitogenic stimuli that regulate cdo mRNA levels, and substratum-derived signals that regulate CDO protein production. cdo mRNA is expressed at low levels in most adult rat tissues. A closely related human gene maps to chromosome 11q23\u201324, a region that displays frequent loss of heterozygosity in human lung, breast, and ovarian tumors. Taken together, these data suggest that loss of CDO function could play a role in oncogenesis.<\/jats:p>","DOI":"10.1083\/jcb.138.1.203","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T12:47:50Z","timestamp":1027687670000},"page":"203-213","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":87,"title":["CDO: An Oncogene-, Serum-, and Anchorage-regulated Member of the Ig\/Fibronectin Type III Repeat Family"],"prefix":"10.1083","volume":"138","author":[{"given":"Jong-Sun","family":"Kang","sequence":"first","affiliation":[{"name":"*Department of Biochemistry, \u2021Department of Human Genetics, Mount Sinai School of Medicine, New York 10029; and \u00a7Zymed Laboratories, South San Francisco, California 94080"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Gao","sequence":"additional","affiliation":[{"name":"*Department of Biochemistry, \u2021Department of Human Genetics, Mount Sinai School of Medicine, New York 10029; and \u00a7Zymed Laboratories, South San Francisco, California 94080"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica L.","family":"Feinleib","sequence":"additional","affiliation":[{"name":"*Department of Biochemistry, \u2021Department of Human Genetics, Mount Sinai School of Medicine, New York 10029; and \u00a7Zymed Laboratories, South San Francisco, California 94080"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip D.","family":"Cotter","sequence":"additional","affiliation":[{"name":"*Department of Biochemistry, \u2021Department of Human Genetics, Mount Sinai School of Medicine, New York 10029; and \u00a7Zymed Laboratories, South San Francisco, California 94080"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah N.","family":"Guadagno","sequence":"additional","affiliation":[{"name":"*Department of Biochemistry, \u2021Department of Human Genetics, Mount Sinai School of Medicine, New York 10029; and \u00a7Zymed Laboratories, South San Francisco, California 94080"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"Krauss","sequence":"additional","affiliation":[{"name":"*Department of Biochemistry, \u2021Department of Human Genetics, Mount Sinai School of Medicine, New York 10029; and \u00a7Zymed Laboratories, South San Francisco, California 94080"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1997,7,14]]},"reference":[{"key":"2023072822535485700_B1","first-page":"451","article-title":"Suppression of the transformed phenotypes of human fibrosarcoma cells by overexpression of recombinant fibronectin","volume":"56","author":"Akamatsu","year":"1996","journal-title":"Cancer Res"},{"key":"2023072822535485700_B2","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1083\/jcb.115.6.1751","article-title":"Neural cell adhesion molecule mediates contact-dependent inhibition of growth of near-diploid mouse fibroblast cell line m5S\/1M","volume":"115","author":"Aoki","year":"1991","journal-title":"J Cell Biol"},{"key":"2023072822535485700_B3","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1073\/pnas.69.6.1408","article-title":"Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose","volume":"69","author":"Aviv","year":"1972","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023072822535485700_B4","first-page":"1919","article-title":"E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain","volume":"13","author":"Berx","year":"1996","journal-title":"Oncogene"},{"key":"2023072822535485700_B5","doi-asserted-by":"crossref","first-page":"12900","DOI":"10.1016\/S0021-9258(18)42360-5","article-title":"Expression of four protein kinase C isoforms in rat fibroblasts. 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