{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:33:02Z","timestamp":1791311582936,"version":"4.3.1"},"reference-count":82,"publisher":"Rockefeller University Press","issue":"1","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1998,4,6]]},"abstract":"<jats:p>Recent studies with patients suffering from epidermolysis bullosa simplex associated with muscular dystrophy and the targeted gene disruption in mice suggested that plectin, a versatile cytoskeletal linker and intermediate filament-binding protein, may play an essential role in hemidesmosome integrity and stabilization. To define plectin's interactions with hemidesmosomal proteins on the molecular level, we studied its interaction with the uniquely long cytoplasmic tail domain of the \u03b24 subunit of the basement membrane laminin receptor integrin \u03b16\u03b24 that has been implicated in connecting the transmembrane integrin complex with hemidesmosome-anchored cytokeratin filaments. In vitro binding and in vivo cotransfection assays, using recombinant mutant forms of both proteins, revealed their direct interaction via multiple molecular domains. Furthermore, we show in vitro self-interaction of integrin \u03b24 cytoplasmic domains, as well as disruption of intermediate filament network arrays and dislocation of hemidesmosome-associated endogenous plectin upon ectopic overexpression of this domain in PtK2 and\/or 804G cells. The close association of plectin molecules with hemidesmosomal structures and their apparent random orientation was indicated by gold immunoelectron microscopy using domain-specific antibodies. Our data support a model in which plectin stabilizes hemidesmosomes, via directly interlinking integrin \u03b24 subunits and cytokeratin filaments.<\/jats:p>","DOI":"10.1083\/jcb.141.1.209","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:47:50Z","timestamp":1027702070000},"page":"209-225","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":207,"title":["Linking Integrin \u03b16\u03b24-based Cell Adhesion to the Intermediate Filament Cytoskeleton: Direct Interaction between the \u03b24 Subunit and Plectin at Multiple Molecular Sites"],"prefix":"10.1083","volume":"141","author":[{"given":"G\u00fcnther A.","family":"Rezniczek","sequence":"first","affiliation":[{"name":"Institute of Biochemistry and Molecular Cell Biology, Vienna Biocenter, 1030 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"de Pereda","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Molecular Cell Biology, Vienna Biocenter, 1030 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siegfried","family":"Reipert","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Molecular Cell Biology, Vienna Biocenter, 1030 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Wiche","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Molecular Cell Biology, Vienna Biocenter, 1030 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1998,4,6]]},"reference":[{"key":"2023072207414592600_B1","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1083\/jcb.105.2.791","article-title":"The expression of mutant epidermal keratin cDNAs transfected in simple epithelial and squamous cell carcinoma 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HD1\/ plectin in COS-7 cells","volume":"110","author":"Niessen","year":"1997","journal-title":"J Cell Sci"},{"key":"2023072207414592600_B46","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1091\/mbc.8.4.555","article-title":"Integrin \u03b16\u03b24forms a complex with the cytoskeletal protein HD1 and induces its redistribution in transfected COS-7 cells","volume":"8","author":"Niessen","year":"1997","journal-title":"Mol Biol Cell"},{"key":"2023072207414592600_B47","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1083\/jcb.134.6.1455","article-title":"Basic amino acid residue cluster within nuclear targeting sequence motif is essential for cytoplasmic plectin-vimentin network junctions","volume":"134","author":"Nikolic","year":"1996","journal-title":"J Cell Biol"},{"key":"2023072207414592600_B48","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/0014-4827(91)90084-8","article-title":"Isolation and characterization of hemidesmosomes from bovine corneal epithelial cells","volume":"192","author":"Owaribe","year":"1991","journal-title":"Exp Cell Res"},{"key":"2023072207414592600_B49","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1128\/mr.59.1.94-123.1995","article-title":"Protein-protein interactions: methods for detection and analysis","volume":"59","author":"Phizicky","year":"1995","journal-title":"Microbiol Rev"},{"key":"2023072207414592600_B50"},{"key":"2023072207414592600_B51","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1093\/hmg\/5.10.1539","article-title":"Homozygous deletion mutations in the plectin gene (PLEC1) in patients with epidermolysis bullosa simplex associated with late-onset muscular dystrophy","volume":"5","author":"Pulkkinen","year":"1996","journal-title":"Hum Mol Genet"},{"key":"2023072207414592600_B52","first-page":"823","article-title":"Genomic organization of the integrin \u03b24gene (ITGB4): a homozygous splice-site mutation in a patient with junctional epidermolysis bullosa associated with pyloric atresia","volume":"76","author":"Pulkkinen","year":"1997","journal-title":"Lab Invest"},{"key":"2023072207414592600_B53","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1111\/1523-1747.ep12876275","article-title":"Immunogold staining of intermediate-sized filaments of the vimentin type in human skin: a postembedding immunoelectron microscopic study","volume":"94","author":"Rappersberger","year":"1990","journal-title":"J Invest Dermatol"},{"key":"2023072207414592600_B54","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1083\/jcb.112.1.159","article-title":"Formation of hemidesmosomes in vitro by a transformed rat bladder cell line","volume":"112","author":"Riddelle","year":"1991","journal-title":"J Cell Biol"},{"key":"2023072207414592600_B55","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1242\/jcs.103.2.475","article-title":"Hemidesmosomes in the epithelial cell line 804G: their fate during wound closure, mitosis and drug induced 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