{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:24:11Z","timestamp":1779344651913,"version":"3.51.4"},"reference-count":42,"publisher":"Rockefeller University Press","issue":"2","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1998,4,20]]},"abstract":"<jats:p>After injury, the peripheral nervous system (PNS) is capable of full regeneration and recovery of function. Many molecular events that are the hallmarks of the regenerating PNS are recapitulations of developmental processes. The expression of one such molecule, the POU transcription factor suppressed cAMP-inducible POU protein (SCIP), is required for the establishment of normal nerves and is reexpressed during regeneration. Here we describe markedly accelerated regeneration and hypertrophy of both myelin and axons in transgenic mice that express an amino-terminal deletion of the SCIP molecule. This mutant SCIP molecule retains the POU-specific and POU homeodomain moieties, which allow for both DNA binding and some protein\u2013protein interaction. We demonstrate that the transgene indirectly effects dramatic axonal changes. This is the first demonstration of a genetically controlled acceleration of neural regeneration.<\/jats:p>","DOI":"10.1083\/jcb.141.2.493","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:47:50Z","timestamp":1027702070000},"page":"493-501","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Accelerated Nerve Regeneration Mediated by Schwann Cells Expressing a Mutant Form of the POU Protein SCIP"],"prefix":"10.1083","volume":"141","author":[{"given":"Marjorie","family":"Gondr\u00e9","sequence":"first","affiliation":[{"name":"*The Department of Neuroscience and the Department of Pathology, The Albert Einstein College of Medicine, Bronx, New York 10461; and \u2021The Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Burrola","sequence":"additional","affiliation":[{"name":"*The Department of Neuroscience and the Department of Pathology, The Albert Einstein College of Medicine, Bronx, New York 10461; and \u2021The Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E.","family":"Weinstein","sequence":"additional","affiliation":[{"name":"*The Department of Neuroscience and the Department of Pathology, The Albert Einstein College of Medicine, Bronx, New York 10461; and \u2021The Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1998,4,20]]},"reference":[{"key":"2023072207393498000_B1","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1097\/00005072-197304000-00006","article-title":"A quantitative ultrastructural study of regeneration from isolated proximal stumps of transected unmyelinated nerves","volume":"32","author":"Aguayo","year":"1973","journal-title":"J Neuropathol Exp Neurol"},{"key":"2023072207393498000_B2","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1101\/gad.10.14.1751","article-title":"Tst-1\/Oct-6\/SCIP regulates a unique step in peripheral myelination and is required for normal respiration","volume":"10","author":"Bermingham","year":"1996","journal-title":"Genes Dev"},{"key":"2023072207393498000_B3","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1002\/(SICI)1097-4547(19971201)50:5<821::AID-JNR18>3.0.CO;2-3","article-title":"Abnormal nerve conduction in mice expressing a targeted amino terminal deletion of the POU transcription factor SCIP","volume":"50","author":"Bieri","year":"1997","journal-title":"J Neurosci Res"},{"key":"2023072207393498000_B4","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0022-510X(89)90073-7","article-title":"Central axons in injured cat spinal cord recover electrophysiological function following remyelination by Schwann cells","volume":"91","author":"Blight","year":"1989","journal-title":"J Neurol Sci"},{"key":"2023072207393498000_B5","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0006-8993(72)90532-X","article-title":"Reactions of unmyelinated nerve fibers to injury. 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