{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:19:59Z","timestamp":1791047999097,"version":"4.1.0"},"reference-count":78,"publisher":"Rockefeller University Press","issue":"6","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1999,6,14]]},"abstract":"<jats:p>It is well established that mutations in the presenilin 1 and 2 genes cause the majority of early onset Alzheimer's disease (AD). However, our understanding of the cellular functions of the proteins they encode remains rudimentary. Knowledge of proteins with which the presenilins interact should lead to a better understanding of presenilin function in normal and disease states. We report here the identification of a calcium-binding protein, calmyrin, that interacts preferentially with presenilin 2 (PS2). Calmyrin is myristoylated, membrane-associated, and colocalizes with PS2 when the two proteins are overexpressed in HeLa cells. Yeast two-hybrid liquid assays, affinity chromatography, and coimmunoprecipitation experiments confirm binding between PS2 and calmyrin. Functionally, calmyrin and PS2 increase cell death when cotransfected into HeLa cells. These results allude to several provocative possibilities for a dynamic role of calmyrin in signaling, cell death, and AD.<\/jats:p>","DOI":"10.1083\/jcb.145.6.1277","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:45:41Z","timestamp":1027701941000},"page":"1277-1292","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":111,"title":["A Myristoylated Calcium-binding Protein that Preferentially Interacts with the Alzheimer's Disease Presenilin 2 Protein"],"prefix":"10.1083","volume":"145","author":[{"given":"Stacy M.","family":"Stabler","sequence":"first","affiliation":[{"name":"*Medical Biotechnology Center and Department of Neurology and \u2021Division of Human Genetics, University of Maryland, Baltimore, Maryland 21201"},{"name":"*Medical Biotechnology Center and Department of Neurology and \u2021Division of Human Genetics, University of Maryland, Baltimore, Maryland 21201"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa L.","family":"Ostrowski","sequence":"additional","affiliation":[{"name":"*Medical Biotechnology Center and Department of Neurology and \u2021Division of Human Genetics, University of Maryland, Baltimore, Maryland 21201"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Janicki","sequence":"additional","affiliation":[{"name":"*Medical Biotechnology Center and Department of Neurology and \u2021Division of Human Genetics, University of Maryland, Baltimore, Maryland 21201"},{"name":"*Medical Biotechnology Center and Department of Neurology and \u2021Division of Human Genetics, University of Maryland, Baltimore, Maryland 21201"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mervyn J.","family":"Monteiro","sequence":"additional","affiliation":[{"name":"*Medical Biotechnology Center and Department of Neurology and \u2021Division of Human Genetics, University of Maryland, Baltimore, Maryland 21201"},{"name":"*Medical Biotechnology Center and Department of Neurology and \u2021Division of Human Genetics, University of Maryland, Baltimore, Maryland 21201"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1999,6,14]]},"reference":[{"key":"2023072901394838500_B1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/38310","article-title":"Molecular mechanics of calcium-myristoyl switches","volume":"389","author":"Ames","year":"1997","journal-title":"Nature"},{"key":"2023072901394838500_B2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1046\/j.1365-4624.1997.00012.x","article-title":"Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegansNotch signaling independently of proteolytic processing","volume":"1","author":"Baumeister","year":"1997","journal-title":"Genes 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