{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:38:54Z","timestamp":1791095934389,"version":"4.1.0"},"reference-count":54,"publisher":"Rockefeller University Press","issue":"2","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1999,7,26]]},"DOI":"10.1083\/jcb.146.2.267","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:45:41Z","timestamp":1027701941000},"page":"267-272","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":223,"title":["Signaling to Actin Dynamics"],"prefix":"10.1083","volume":"146","author":[{"given":"Laura M.","family":"Machesky","sequence":"first","affiliation":[{"name":"aDepartment of Biochemistry, University of Birmingham, Birmingham, B15 2TT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"Insall","sequence":"additional","affiliation":[{"name":"aDepartment of Biochemistry, University of Birmingham, Birmingham, B15 2TT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1999,7,26]]},"reference":[{"key":"2023072901234914400_Aspenstrometal1996","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0960-9822(02)00423-2","article-title":"Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich Syndrome","volume":"6","author":"Aspenstrom","year":"1996","journal-title":"Curr. Biol."},{"key":"2023072901234914400_Aszodietal1999","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/emboj\/18.1.37","article-title":"The vasodilator-stimulated phosphoprotein (VASP) is involved in cGMP- and cAMP-mediated inhibition of agonist-induced platelet aggregation, but is dispensable for smooth muscle function","volume":"18","author":"Aszodi","year":"1999","journal-title":"EMBO (Eur. Mol. Biol. Organ.) J."},{"key":"2023072901234914400_Azumaetal1998","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1093\/emboj\/17.5.1362","article-title":"Gelsolin is a downstream effector of Rac for fibroblast motility","volume":"17","author":"Azuma","year":"1998","journal-title":"EMBO (Eur. Mol. Biol. Organ.) J."},{"key":"2023072901234914400_Baillyetal1999","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1083\/jcb.145.2.331","article-title":"Relationship between the Arp2\/3 complex and the barbed ands of actin filaments at the leading edge of carcinoma cells after epidermal growth factor stimulation","volume":"145","author":"Bailly","year":"1999","journal-title":"J. Cell Biol."},{"key":"2023072901234914400_Barkalowetal1996","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1083\/jcb.134.2.389","article-title":"Coordinated regulation of platelet actin filament barbed ends by gelsolin and capping protein","volume":"134","author":"Barkalow","year":"1996","journal-title":"J. Cell Biol."},{"key":"2023072901234914400_Bearetal1998","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1083\/jcb.142.5.1325","article-title":"Scar1, a WASP-related protein, isolated as a suppressor of receptor defects late in development","volume":"142","author":"Bear","year":"1998","journal-title":"J. Cell Biol."},{"key":"2023072901234914400_Burbeloetal1995","doi-asserted-by":"crossref","first-page":"29071","DOI":"10.1074\/jbc.270.49.29071","article-title":"A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases","volume":"270","author":"Burbelo","year":"1995","journal-title":"J. Biol. Chem."},{"key":"2023072901234914400_Derryetal1994","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/0092-8674(94)90528-2","article-title":"Isolation of a novel gene mutated in Wiskott-Aldrich Syndrome","volume":"78","author":"Derry","year":"1994","journal-title":"Cell."},{"key":"2023072901234914400_DiNubileandHuang1997","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0167-4889(97)00076-1","article-title":"High concentrations of phosphatidylinositol-4,5-bisphosphate may promote actin filament growth by three potential mechanismsinhibiting capping by neutrophil lysates, severing actin filaments and removing capping protein-beta2 from barbed ends","volume":"1358","author":"DiNubile","year":"1997","journal-title":"Biochim. Biophys. Acta."},{"key":"2023072901234914400_Eddyetal1997","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1083\/jcb.139.5.1243","article-title":"Capping protein terminates but does not initiate chemoattractant-induced actin assembly in Dictyostelium","volume":"139","author":"Eddy","year":"1997","journal-title":"J. Cell Biol."},{"key":"2023072901234914400_Gertleretal1995","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1101\/gad.9.5.521","article-title":"enabled, a dosage-sensitive suppressor of mutations in the Drosophila Abl tyrosine kinase, encodes an Abl substrate with SH3 domain-binding properties","volume":"9","author":"Gertler","year":"1995","journal-title":"Genes Dev."},{"key":"2023072901234914400_HalbruggeandWalter1989","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1432-1033.1989.tb15079.x","article-title":"Purification of a vasodilator-regulated phosphoprotein from human platelets","volume":"185","author":"Halbrugge","year":"1989","journal-title":"Eur. J. Biochem."},{"key":"2023072901234914400_Hartwigetal1995","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/0092-8674(95)90036-5","article-title":"Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets","volume":"82","author":"Hartwig","year":"1995","journal-title":"Cell."},{"key":"2023072901234914400_Hausetal1991","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/0006-291X(91)91265-E","article-title":"F-actin capping by cap32\/34 requires heterodimeric conformation and can be inhibited with PIP2","volume":"181","author":"Haus","year":"1991","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2023072901234914400_HeissandCooper1991","doi-asserted-by":"crossref","first-page":"8753","DOI":"10.1021\/bi00100a006","article-title":"Regulation of CapZ, an actin capping protein of chicken muscle, by anionic phospholipids","volume":"30","author":"Heiss","year":"1991","journal-title":"Biochemistry."},{"key":"2023072901234914400_Hugetal1995","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/0092-8674(95)90080-2","article-title":"Capping protein levels influence actin assembly and cell motility in Dictyostelium","volume":"81","author":"Hug","year":"1995","journal-title":"Cell."},{"key":"2023072901234914400_InsallandMachesky1999","first-page":"211","article-title":"PH domains in WASP\u2014a bug in the system?","volume":"9","author":"Insall","year":"1999","journal-title":"Trends Cell Biol."},{"key":"2023072901234914400_Lanieretal1999","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0896-6273(00)81092-2","article-title":"Mena is required for neurulation and commissure formation","volume":"22","author":"Lanier","year":"1999","journal-title":"Neuron."},{"key":"2023072901234914400_Laurentetal1999","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1083\/jcb.144.6.1245","article-title":"Role of proteins of the Ena\/VASP family in actin-based motility of Listeria monocytogenes","volume":"144","author":"Laurent","year":"1999","journal-title":"J. Cell Biol."},{"key":"2023072901234914400_Maetal1998a","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1083\/jcb.140.5.1125","article-title":"Corequirement of specific phosphoinositides and small GTP-binding protein Cdc42 in inducing actin assembly in Xenopus egg extracts","volume":"140","author":"Ma","year":"1998","journal-title":"J. Cell Biol."},{"key":"2023072901234914400_Maetal1998b","doi-asserted-by":"crossref","first-page":"15362","DOI":"10.1073\/pnas.95.26.15362","article-title":"The Arp2\/3 complex mediates actin polymerization induced by the small GTP-binding protein Cdc42","volume":"95","author":"Ma","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072901234914400_Macheskyetal1994","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1083\/jcb.127.1.107","article-title":"Purification of a cortical complex containing 2 unconventional actins from Acanthamoeba by affinity-chromatography on profilin-agarose","volume":"127","author":"Machesky","year":"1994","journal-title":"J. Cell Biol."},{"key":"2023072901234914400_MacheskyandInsall1998","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/S0960-9822(98)00015-3","article-title":"Scar1 and the related Wiskott Aldrich Syndrome protein WASp regulate the actin cytoskeleton through the Arp2\/3 complex","volume":"8","author":"Machesky","year":"1998","journal-title":"Curr. Biol."},{"key":"2023072901234914400_Macheskyetal1999","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.1073\/pnas.96.7.3739","article-title":"WASp-related protein Scar activates dendritic nucleation of actin filaments by Arp2\/3 complex","volume":"96","author":"Machesky","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072901234914400_Macheskyetal1997","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1042\/bj3280105","article-title":"The mammalian Arp2\/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins","volume":"328","author":"Machesky","year":"1997","journal-title":"Biochem. J."},{"key":"2023072901234914400_Maciver1998","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0955-0674(98)80097-5","article-title":"How ADF\/cofilin depolymerizes actin filaments","volume":"10","author":"Maciver","year":"1998","journal-title":"Curr. Opin. Cell Biol."},{"key":"2023072901234914400_Mayetal1999","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0960-9822(99)80337-6","article-title":"The Arp2\/3 complex is essential for the actin-based motility of Listeria monocytogenes","volume":"9","author":"May","year":"1999","journal-title":"Curr. Biol."},{"key":"2023072901234914400_Meerschaertetal1998","doi-asserted-by":"crossref","first-page":"5923","DOI":"10.1093\/emboj\/17.20.5923","article-title":"Gelsolin and functionally similar actin-binding proteins are regulated by lysophosphatidic acid","volume":"17","author":"Meerschaert","year":"1998","journal-title":"EMBO (Eur. Mol. Biol. Organ.) J."},{"key":"2023072901234914400_Mikietal1996","doi-asserted-by":"crossref","first-page":"5326","DOI":"10.1002\/j.1460-2075.1996.tb00917.x","article-title":"N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases","volume":"15","author":"Miki","year":"1996","journal-title":"EMBO (Eur. Mol. Biol. Organ.) J."},{"key":"2023072901234914400_Mikietal1997","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/34208","article-title":"Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP","volume":"391","author":"Miki","year":"1997","journal-title":"Nature."},{"key":"2023072901234914400_Mikietal1998","doi-asserted-by":"crossref","first-page":"6932","DOI":"10.1093\/emboj\/17.23.6932","article-title":"WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac","volume":"17","author":"Miki","year":"1998","journal-title":"EMBO (Eur. Mol. Biol. Organ.) J."},{"key":"2023072901234914400_MikiandTakenawa1998","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1006\/bbrc.1997.8064","article-title":"Direct binding of the verprolin-homology domain in N-WASP to actin is essential for cytoskeletal reorganization","volume":"243","author":"Miki","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2023072901234914400_MoreauandWay1998","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0014-5793(98)00443-8","article-title":"Cdc42 is required for membrane dependent actin polymerization in vitro","volume":"427","author":"Moreau","year":"1998","journal-title":"FEBS Lett."},{"key":"2023072901234914400_Mullinsetal1998","doi-asserted-by":"crossref","first-page":"6181","DOI":"10.1073\/pnas.95.11.6181","article-title":"The interaction of Arp2\/3 complex with actinNucleation, high affinity pointed end capping, and formation of branching networks of filaments","volume":"95","author":"Mullins","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072901234914400_MullinsandPollard1999","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S0960-9822(99)80187-0","article-title":"Rho-family GTPases require the Arp2\/3 complex to stimulate actin polymerization in Acanthamoeba extracts","volume":"9","author":"Mullins","year":"1999","journal-title":"Curr. Biol."},{"key":"2023072901234914400_Mullinsetal1997","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1083\/jcb.136.2.331","article-title":"Structure, subunit topology, and actin-binding activity of the Arp2\/3 complex from Acanthamoeba","volume":"136","author":"Mullins","year":"1997","journal-title":"J. Cell Biol."},{"key":"2023072901234914400_Prehodaetal1999","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0092-8674(00)80757-6","article-title":"Structure of the enabled\/VASP homology 1 domain-peptide complexa key component in the spatial control of actin assembly","volume":"97","author":"Prehoda","year":"1999","journal-title":"Cell."},{"key":"2023072901234914400_Rameshetal1997","doi-asserted-by":"crossref","first-page":"14671","DOI":"10.1073\/pnas.94.26.14671","article-title":"WIP, a protein associated with Wiskott-Aldrich Syndrome protein, induces actin polymerization and redistribution in lymphoid cells","volume":"94","author":"Ramesh","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072901234914400_Rameshetal1999","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0962-8924(98)01411-1","article-title":"Waltzing with WASP","volume":"9","author":"Ramesh","year":"1999","journal-title":"Trends Cell Biol."},{"key":"2023072901234914400_Ressadetal1999","article-title":"Control of actin filament length and turnover by actin depolymerizing factor (ADF\/cofilin) in the presence of capping proteins and Arp2\/3 complex","volume":"In press","author":"Ressad","year":"1999","journal-title":"J. Biol. Chem."},{"key":"2023072901234914400_Rohatgietal1999","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0092-8674(00)80732-1","article-title":"The interaction between N-WASP and the Arp2\/3 complex links Cdc42-dependent signals to actin assembly","volume":"97","author":"Rohatgi","year":"1999","journal-title":"Cell."},{"key":"2023072901234914400_Schaferetal1996","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1083\/jcb.135.1.169","article-title":"Dynamics of capping protein and actin assembly in vitrouncapping barbed ends by polyphosphoinositides","volume":"135","author":"Schafer","year":"1996","journal-title":"J. Cell Biol."},{"key":"2023072901234914400_Schaferetal1998","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1083\/jcb.143.7.1919","article-title":"Visualization and molecular analysis of actin assembly in living cells","volume":"143","author":"Schafer","year":"1998","journal-title":"J. Cell Biol."},{"key":"2023072901234914400_Suetsuguetal1998","doi-asserted-by":"crossref","first-page":"6516","DOI":"10.1093\/emboj\/17.22.6516","article-title":"The essential role of profilin in the assembly of actin for microspike formation","volume":"17","author":"Suetsugu","year":"1998","journal-title":"EMBO (Eur. Mol. Biol. Organ.) J."},{"key":"2023072901234914400_SvitkinaandBorisy1999","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1083\/jcb.145.5.1009","article-title":"Arp2\/3 complex and ADF\/cofilin in dendritic organization and treadmilling of actin filament array in lamellipodia","volume":"145","author":"Svitkina","year":"1999","journal-title":"J. Cell Biol."},{"key":"2023072901234914400_Svitkinaetal1997","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1083\/jcb.139.2.397","article-title":"Analysis of the actin-myosin II system in fish epidermal keratocytesmechanism of cell body translocation","volume":"139","author":"Svitkina","year":"1997","journal-title":"J. Cell Biol."},{"key":"2023072901234914400_Symonsetal1996","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0092-8674(00)81050-8","article-title":"Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization","volume":"84","author":"Symons","year":"1996","journal-title":"Cell."},{"key":"2023072901234914400_Welchetal1997a","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1083\/jcb.138.2.375","article-title":"The human Arp2\/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly","volume":"138","author":"Welch","year":"1997","journal-title":"J. Cell Biol."},{"key":"2023072901234914400_Welchetal1997b","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/385265a0","article-title":"Actin polymerization is induced by the Arp2\/3 protein complex at the surface of Listeria monocytogenes","volume":"385","author":"Welch","year":"1997","journal-title":"Nature."},{"key":"2023072901234914400_Welchetal1998","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1126\/science.281.5373.105","article-title":"Interaction of Arp2\/3 complex and the Listeria monocytogenes ActA protein in actin filament nucleation","volume":"281","author":"Welch","year":"1998","journal-title":"Science."},{"key":"2023072901234914400_Winteretal1999","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0960-9822(99)80218-8","article-title":"Activation of the yeast Arp2\/3 complex by Bee1p, a WASP-family protein","volume":"9","author":"Winter","year":"1999","journal-title":"Curr. Biol."},{"key":"2023072901234914400_Witkeetal1995","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0092-8674(95)90369-0","article-title":"Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin","volume":"81","author":"Witke","year":"1995","journal-title":"Cell."},{"key":"2023072901234914400_Yararetal1999","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0960-9822(99)80243-7","article-title":"The Wiskott-Aldrich Syndrome protein directs actin-based motility by stimulating actin nucleation with the Arp2\/3 complex","volume":"9","author":"Yarar","year":"1999","journal-title":"Curr. Biol."},{"key":"2023072901234914400_Zigmondetal1997","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1083\/jcb.138.2.363","article-title":"Regulation of actin polymerization in cell-free systems by GTPgS and Cdc42","volume":"138","author":"Zigmond","year":"1997","journal-title":"J. Cell Biol."}],"container-title":["The Journal of Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/146\/2\/267\/1853936\/9905119.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/146\/2\/267\/1853936\/9905119.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,29]],"date-time":"2023-07-29T01:24:33Z","timestamp":1690593873000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jcb\/article\/146\/2\/267\/52555\/Signaling-to-Actin-Dynamics"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,7,26]]},"references-count":54,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1999,7,26]]}},"URL":"https:\/\/doi.org\/10.1083\/jcb.146.2.267","relation":{},"ISSN":["0021-9525","1540-8140"],"issn-type":[{"value":"0021-9525","type":"print"},{"value":"1540-8140","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,7,26]]}}}