{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:12:20Z","timestamp":1791299540483,"version":"4.1.0"},"reference-count":49,"publisher":"Rockefeller University Press","issue":"1","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1999,10,4]]},"DOI":"10.1083\/jcb.147.1.1","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:45:41Z","timestamp":1027701941000},"page":"1-5","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":121,"title":["Regulated Secretion from Hemopoietic Cells"],"prefix":"10.1083","volume":"147","author":[{"given":"Jane C.","family":"Stinchcombe","sequence":"first","affiliation":[{"name":"aSir William Dunn School of Pathology, University of Oxford, OX1 3RE United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian M.","family":"Griffiths","sequence":"additional","affiliation":[{"name":"aSir William Dunn School of Pathology, University of Oxford, OX1 3RE United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1999,10,4]]},"reference":[{"key":"2023072900534199100_ArvanandCastle1998","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1042\/bj3320593","article-title":"Sorting and storage during secretory granule biogenesislooking backward and looking forward","volume":"332","author":"Arvan","year":"1998","journal-title":"Biochem. J."},{"key":"2023072900534199100_Baetzetal1995","doi-asserted-by":"crossref","first-page":"6122","DOI":"10.4049\/jimmunol.154.11.6122","article-title":"Loss of cytotoxic T lymphocyte function in Chediak-Higashi syndrome arises from a secretory defect that prevents lytic granule exocytosis","volume":"154","author":"Baetz","year":"1995","journal-title":"J. Immunol."},{"key":"2023072900534199100_Barametal1999","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1084\/jem.189.10.1649","article-title":"Synaptotagmin II negatively regulates Ca2+-triggered exocytosis of lysosomes in mast cells","volume":"189","author":"Baram","year":"1999","journal-title":"J. Exp. Med."},{"key":"2023072900534199100_Barbosaetal1996","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/382262a0","article-title":"Identification of the homologous beige and Chediak-Higashi syndrome genes [published erratum appears in Nature 385:97]","volume":"382","author":"Barbosa","year":"1996","journal-title":"Nature"},{"key":"2023072900534199100_N0x276a000N0x2e4e918","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/4779","article-title":"Degranulation plays an essential part in regulating cell surface expression of Fas ligand in T cells and natural killer cells","volume":"5","author":"Bossi","year":"1999","journal-title":"Nat. Med."},{"key":"2023072900534199100_Brumelletal1995","doi-asserted-by":"crossref","first-page":"5750","DOI":"10.4049\/jimmunol.155.12.5750","article-title":"Subcellular distribution of docking\/fusion proteins in neutrophils, secretory cells with multiple exocytic compartments","volume":"155","author":"Brumell","year":"1995","journal-title":"J. Immunol."},{"key":"2023072900534199100_N0x276a000N0x2e4f920","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1146\/annurev.cb.03.110187.001331","article-title":"Constitutive and regulated secretion of proteins","volume":"3","author":"Burgess","year":"1987","journal-title":"Annu. Rev. Cell Biol."},{"key":"2023072900534199100_Burkhardtetal1993","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1084\/jem.178.6.1845","article-title":"The giant organelles in beige and Chediak-Higashi fibroblasts are derived from late endosomes and mature lysosomes","volume":"178","author":"Burkhardt","year":"1993","journal-title":"J. Exp. Med."},{"key":"2023072900534199100_Caleretal1998","doi-asserted-by":"crossref","first-page":"4975","DOI":"10.1093\/emboj\/17.17.4975","article-title":"Oligopeptidase B-dependent signaling mediates host cell invasion by Trypanosoma cruzi","volume":"17","author":"Caler","year":"1998","journal-title":"EMBO (Eur. Mol. Biol. Organ.) J."},{"key":"2023072900534199100_ChanatandHuttner1991","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1083\/jcb.115.6.1505","article-title":"Milieu-induced, selective aggregation of regulated secretory proteins in the trans-Golgi network","volume":"115","author":"Chanat","year":"1991","journal-title":"J. Cell Biol."},{"key":"2023072900534199100_Coorssenetal1996","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1002\/j.1460-2075.1996.tb00752.x","article-title":"Ca2+ triggers massive exocytosis in Chinese hamster ovary cells","volume":"15","author":"Coorssen","year":"1996","journal-title":"EMBO (Eur. Mol. Biol. Organ.) J."},{"key":"2023072900534199100_DellAngelicaetal1999","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S1097-2765(00)80170-7","article-title":"Altered trafficking of lysosomal proteins in Hermansky-Pudlak syndrome due to mutations in the beta 3A subunit of the AP-3 adaptor","volume":"3","author":"Dell'Angelica","year":"1999","journal-title":"Mol. Cell."},{"key":"2023072900534199100_Ebertetal1990","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1242\/jcs.96.3.491","article-title":"Lysosomal enzyme secretory mutants of Dictyostelium discoideum","volume":"96","author":"Ebert","year":"1990","journal-title":"J. Cell Sci."},{"key":"2023072900534199100_Fengetal1999","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1093\/hmg\/8.2.323","article-title":"The beta3A subunit gene (Ap3b1) of the AP-3 adaptor complex is altered in the mouse hypopigmentation mutant pearl, a model for Hermansky-Pudlak syndrome and night blindness","volume":"8","author":"Feng","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"2023072900534199100_FingerandNovick1998","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1083\/jcb.142.3.609","article-title":"Spatial regulation of exocytosislessons from yeast","volume":"142","author":"Finger","year":"1998","journal-title":"J. Cell Biol."},{"key":"2023072900534199100_Fischeretal1986","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/S0140-6736(86)90477-0","article-title":"Bone-marrow transplantation for immunodeficiencies and osteopetrosiseuropean survey, 1968\u20131985","volume":"2","author":"Fischer","year":"1986","journal-title":"Lancet"},{"key":"2023072900534199100_Gardneretal1997","doi-asserted-by":"crossref","first-page":"9238","DOI":"10.1073\/pnas.94.17.9238","article-title":"The mouse pale ear (ep) mutation is the homologue of human Hermansky- Pudlak syndrome","volume":"94","author":"Gardner","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072900534199100_Griffiths1996","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0962-8924(96)20031-5","article-title":"Secretory lysosomes-a special mechanism of regulated secretion in haemopoieitic cells","volume":"6","author":"Griffiths","year":"1996","journal-title":"Trends Cell Biol."},{"key":"2023072900534199100_GriffithsandIsaaz1993","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1083\/jcb.120.4.885","article-title":"Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor","volume":"120","author":"Griffiths","year":"1993","journal-title":"J. Cell Biol."},{"key":"2023072900534199100_GriffithsandArgon1995","first-page":"39","article-title":"Structure and biogenesis of lytic granules","volume":"198","author":"Griffiths","year":"1995","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"2023072900534199100_Guoetal1998","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0092-8674(00)81594-9","article-title":"Relocation of the t-SNARE SNAP-23 from lamellipodia-like cell surface projections regulates compound exocytosis in mast cells","volume":"94","author":"Guo","year":"1998","journal-title":"Cell"},{"key":"2023072900534199100_Kanthetietal1998","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0896-6273(00)80519-X","article-title":"Mutation in AP-3 delta in the mocha mouse links endosomal transport to storage deficiency in platelets, melanosomes, and synaptic vesicles","volume":"21","author":"Kantheti","year":"1998","journal-title":"Neuron"},{"key":"2023072900534199100_Kleinetal1994","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/S0022-3476(05)82003-7","article-title":"Partial albinism with immunodeficiency (Griscelli syndrome)","volume":"125","author":"Klein","year":"1994","journal-title":"J. Pediatr"},{"key":"2023072900534199100_Klumpermanetal1998","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1083\/jcb.141.2.359","article-title":"Mannose 6-phosphate receptors are sorted from immature secretory granules via adaptor protein AP-1, clathrin, and syntaxin 6-positive vesicles","volume":"141","author":"Klumperman","year":"1998","journal-title":"J. Cell Biol."},{"key":"2023072900534199100_Kuliawatetal1997","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1083\/jcb.137.3.595","article-title":"Differential sorting of lysosomal enzymes out of the regulated secretory pathway in pancreatic beta-cells","volume":"137","author":"Kuliawat","year":"1997","journal-title":"J. Cell Biol."},{"key":"2023072900534199100_N0x276a000N0x2ed8660","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S1074-7613(00)80480-X","article-title":"Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement","volume":"4","author":"Linsley","year":"1996","journal-title":"Immunity"},{"key":"2023072900534199100_Massonetal1990","doi-asserted-by":"crossref","first-page":"11229","DOI":"10.1021\/bi00503a011","article-title":"Interaction of chondroitin sulfate with perforin and granzymes of cytolytic T-cells is dependent on pH","volume":"29","author":"Masson","year":"1990","journal-title":"Biochemistry"},{"key":"2023072900534199100_McNeilandSteinhardt1997","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1083\/jcb.137.1.1","article-title":"Loss, restoration, and maintenance of plasma membrane integrity","volume":"137","author":"McNeil","year":"1997","journal-title":"J. Cell Biol."},{"key":"2023072900534199100_Medleyetal1996","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1073\/pnas.93.2.685","article-title":"Characterization of GMP-17, a granule membrane protein that moves to the plasma membrane of natural killer cells following target cell recognition","volume":"93","author":"Medley","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072900534199100_Merceretal1991","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/349709a0","article-title":"Novel myosin heavy chain encoded by murine dilute coat colour locus [published erratum appears in Nature 352:547]","volume":"349","author":"Mercer","year":"1991","journal-title":"Nature"},{"key":"2023072900534199100_MiyakeandMcNeil1995","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1083\/jcb.131.6.1737","article-title":"Vesicle accumulation and exocytosis at sites of plasma membrane disruption","volume":"131","author":"Miyake","year":"1995","journal-title":"J. Cell Biol."},{"key":"2023072900534199100_Nagleetal1996","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/ng1196-307","article-title":"Identification and mutation analysis of the complete gene for Chediak-Higashi syndrome","volume":"14","author":"Nagle","year":"1996","journal-title":"Nat. Genet."},{"key":"2023072900534199100_Orlow1995","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/1523-1747.ep12312291","article-title":"Melanosomes are specialized members of the lysosomal lineage of organelles","volume":"105","author":"Orlow","year":"1995","journal-title":"J. Invest. Dermatol"},{"key":"2023072900534199100_Pasturaletal1997","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/ng0797-289","article-title":"Griscelli disease maps to chromosome 15q21 and is associated with mutations in the myosin-Va gene","volume":"16","author":"Pastural","year":"1997","journal-title":"Nat. Genet."},{"key":"2023072900534199100_Perouetal1996","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/ng0796-303","article-title":"Identification of the murine beige gene by YAC complementation and positional cloning","volume":"13","author":"Perou","year":"1996","journal-title":"Nat. Genet."},{"key":"2023072900534199100_Perouetal1997","doi-asserted-by":"crossref","first-page":"29790","DOI":"10.1074\/jbc.272.47.29790","article-title":"The Beige\/Chediak-Higashi syndrome gene encodes a widely expressed cytosolic protein","volume":"272","author":"Perou","year":"1997","journal-title":"J. Biol. Chem"},{"key":"2023072900534199100_N0x276a000N0x2df2768","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1084\/jem.183.3.1161","article-title":"B lymphocytes secrete antigen-presenting vesicles","volume":"183","author":"Raposo","year":"1996","journal-title":"J. Exp. Med."},{"key":"2023072900534199100_Raposoetal1997","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1091\/mbc.8.12.2631","article-title":"Accumulation of major histocompatibility complex class II molecules in mast cell secretory granules and their release upon degranulation","volume":"8","author":"Raposo","year":"1997","journal-title":"Mol. Biol. Cell."},{"key":"2023072900534199100_Rodriguezetal1995","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1083\/jcb.129.5.1263","article-title":"A trypanosome-soluble factor induces IP3 formation, intracellular Ca2+ mobilization and microfilament rearrangement in host cells","volume":"129","author":"Rodriguez","year":"1995","journal-title":"J. Cell Biol."},{"key":"2023072900534199100_Rodriguezetal1996","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1083\/jcb.134.2.349","article-title":"Host cell invasion by trypanosomes requires lysosomes and microtubule\/kinesin-mediated transport","volume":"134","author":"Rodriguez","year":"1996","journal-title":"J. Cell Biol."},{"key":"2023072900534199100_Rodriguezetal1997","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1083\/jcb.137.1.93","article-title":"Lysosomes behave as Ca2+-regulated exocytic vesicles in fibroblasts and epithelial cells","volume":"137","author":"Rodriguez","year":"1997","journal-title":"J. Cell Biol."},{"key":"2023072900534199100_Swanketal1998","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1600-0749.1998.tb00713.x","article-title":"Mouse models of Hermansky Pudlak syndromea review","volume":"11","author":"Swank","year":"1998","journal-title":"Pigment Cell Res"},{"key":"2023072900534199100_Tardieuxetal1992","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/S0092-8674(05)80061-3","article-title":"Lysosome recruitment and fusion are early events required for trypanosome invasion of mammalian cells","volume":"71","author":"Tardieux","year":"1992","journal-title":"Cell"},{"key":"2023072900534199100_ThompsonandAllison1997","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S1074-7613(00)80366-0","article-title":"The emerging role of CTLA-4 as an immune attenuator","volume":"7","author":"Thompson","year":"1997","journal-title":"Immunity"},{"key":"2023072900534199100_N0x276a000N0x1ce0b08","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1165\/ajrcmb.20.1.3279","article-title":"Rab3D, a small GTPase, is localized on mast cell secretory granules and translocates to the plasma membrane upon exocytosis","volume":"20","author":"Tuvim","year":"1999","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2023072900534199100_Wuetal1997","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1242\/jcs.110.7.847","article-title":"Myosin V associates with melanosomes in mouse melanocytesevidence that myosin V is an organelle motor","volume":"110","author":"Wu","year":"1997","journal-title":"J. Cell Sci."},{"key":"2023072900534199100_Wuetal1998","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1083\/jcb.143.7.1899","article-title":"Visualization of melanosome dynamics within wild-type and dilute melanocytes suggests a paradigm for myosin V function in vivo","volume":"143","author":"Wu","year":"1998","journal-title":"J. Cell Biol."},{"key":"2023072900534199100_Wubboltsetal1996","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1083\/jcb.135.3.611","article-title":"Direct vesicular transport of MHC class II molecules from lysosomal structures to the cell surface","volume":"135","author":"Wubbolts","year":"1996","journal-title":"J. Cell Biol."},{"key":"2023072900534199100_Zitvogeletal1998","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/nm0598-594","article-title":"Eradication of established murine tumors using a novel cell-free vaccinedendritic cell-derived exosomes","volume":"4","author":"Zitvogel","year":"1998","journal-title":"Nat. Med."}],"container-title":["The Journal of Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/147\/1\/1\/1851791\/9908053.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/147\/1\/1\/1851791\/9908053.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,29]],"date-time":"2023-07-29T00:54:09Z","timestamp":1690592049000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jcb\/article\/147\/1\/1\/31967\/Regulated-Secretion-from-Hemopoietic-Cells"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,10,4]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1999,10,4]]}},"URL":"https:\/\/doi.org\/10.1083\/jcb.147.1.1","relation":{},"ISSN":["0021-9525","1540-8140"],"issn-type":[{"value":"0021-9525","type":"print"},{"value":"1540-8140","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,10,4]]}}}