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In NF-L null mice, the overexpression of peripherin led to early- onset formation of IF inclusions and to the selective death of spinal motor neurons at 6 mo of age. We also report the formation of similar peripherin inclusions in presymptomatic transgenic mice expressing a mutant form of superoxide dismutase linked to ALS. Taken together, these results suggest that IF inclusions containing peripherin may play a contributory role in motor neuron disease.<\/jats:p>","DOI":"10.1083\/jcb.147.3.531","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:45:41Z","timestamp":1027701941000},"page":"531-544","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":207,"title":["Late Onset Death of Motor Neurons in Mice Overexpressing Wild-Type Peripherin"],"prefix":"10.1083","volume":"147","author":[{"given":"Jean-Martin","family":"Beaulieu","sequence":"first","affiliation":[{"name":"aCentre for Research in Neurosciences, McGill University, The Montr\u00e9al General Hospital Research Institute, Montr\u00e9al, Qu\u00e9bec, H3G 1A4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minh Dang","family":"Nguyen","sequence":"additional","affiliation":[{"name":"aCentre for Research in Neurosciences, McGill University, The Montr\u00e9al General Hospital Research Institute, Montr\u00e9al, Qu\u00e9bec, H3G 1A4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Julien","sequence":"additional","affiliation":[{"name":"aCentre for Research in Neurosciences, McGill University, The Montr\u00e9al General Hospital Research Institute, Montr\u00e9al, Qu\u00e9bec, H3G 1A4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1999,11,1]]},"reference":[{"key":"2023072900511685900_AthlanandMushynski1997","doi-asserted-by":"crossref","first-page":"31073","DOI":"10.1074\/jbc.272.49.31073","article-title":"Heterodimeric associations between neuronal intermediate filament proteins","volume":"272","author":"Athlan","year":"1997","journal-title":"J. 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