{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:06:40Z","timestamp":1790921200510,"version":"4.1.0"},"reference-count":86,"publisher":"Rockefeller University Press","issue":"1","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2000,4,3]]},"abstract":"<jats:p>T cell receptor (TCR)-driven activation of helper T cells induces a rapid polarization of their cytoskeleton towards bound antigen presenting cells (APCs). We have identified the Fyn- and SLP-76\u2013associated protein Fyb\/SLAP as a new ligand for Ena\/ vasodilator-stimulated phosphoprotein (VASP) homology 1 (EVH1) domains. Upon TCR engagement, Fyb\/SLAP localizes at the interface between T cells and anti-CD3\u2013coated beads, where Evl, a member of the Ena\/VASP family, Wiskott-Aldrich syndrome protein (WASP) and the Arp2\/3 complex are also found. In addition, Fyb\/SLAP is restricted to lamellipodia of spreading platelets. In activated T cells, Fyb\/SLAP associates with Ena\/VASP family proteins and is present within biochemical complexes containing WASP, Nck, and SLP-76. Inhibition of binding between Fyb\/SLAP and Ena\/VASP proteins or WASP and the Arp2\/3 complex impairs TCR-dependent actin rearrangement, suggesting that these interactions play a key role in linking T cell signaling to remodeling of the actin cytoskeleton.<\/jats:p>","DOI":"10.1083\/jcb.149.1.181","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:45:41Z","timestamp":1027701941000},"page":"181-194","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":256,"title":["Fyn-Binding Protein (Fyb)\/Slp-76\u2013Associated Protein (Slap), Ena\/Vasodilator-Stimulated Phosphoprotein (Vasp) Proteins and the Arp2\/3 Complex Link T Cell Receptor (Tcr) Signaling to the Actin Cytoskeleton"],"prefix":"10.1083","volume":"149","author":[{"given":"Matthias","family":"Krause","sequence":"first","affiliation":[{"name":"aDepartment of Cell Biology, Gesellschaft f\u00fcr Biotechnologische Forschung (GBF), D-38124 Braunschweig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio S.","family":"Sechi","sequence":"additional","affiliation":[{"name":"aDepartment of Cell Biology, Gesellschaft f\u00fcr Biotechnologische Forschung (GBF), D-38124 Braunschweig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlies","family":"Konradt","sequence":"additional","affiliation":[{"name":"aDepartment of Cell Biology, Gesellschaft f\u00fcr Biotechnologische Forschung (GBF), D-38124 Braunschweig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Monner","sequence":"additional","affiliation":[{"name":"aDepartment of Cell Biology, Gesellschaft f\u00fcr Biotechnologische Forschung (GBF), D-38124 Braunschweig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank B.","family":"Gertler","sequence":"additional","affiliation":[{"name":"bDepartment of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02138-4307"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Wehland","sequence":"additional","affiliation":[{"name":"aDepartment of Cell Biology, Gesellschaft f\u00fcr Biotechnologische Forschung (GBF), D-38124 Braunschweig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2000,4,3]]},"reference":[{"key":"2023072902204258600_Abeletal1996","first-page":"39a","article-title":"Monoclonal antibodies against the focal adhesion protein VASP revealing epitopes involved in the interaction with two VASP binding proteins and VASP phosphorylation","volume":"69","author":"Abel","year":"1996","journal-title":"Eur. 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J."},{"key":"2023072902204258600_BubeckWardenburgetal1998","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S1074-7613(00)80658-5","article-title":"Regulation of PAK activation and the T-cell cytoskeleton by the linker protein SLP-76","volume":"9","author":"Bubeck Wardenburg","year":"1998","journal-title":"Immunity."},{"key":"2023072902204258600_Carletal1999","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S0960-9822(99)80315-7","article-title":"Aromatic and basic residues within the EVH1 domain of VASP specify its interaction with proline-rich ligands","volume":"9","author":"Carl","year":"1999","journal-title":"Curr. 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Immunol."},{"key":"2023072902204258600_Crespoetal1997","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/385169a0","article-title":"Phosphotyrosine-dependent activation of Rac-1 GDP\/GTP exchange by the vav proto-oncogene product","volume":"385","author":"Crespo","year":"1997","journal-title":"Nature."},{"key":"2023072902204258600_DaSilvaandRudd1993","doi-asserted-by":"crossref","first-page":"16537","DOI":"10.1016\/S0021-9258(19)85452-2","article-title":"A 72-kilodalton fyn related polypeptide (p72fyn-R) binds to the antigen receptor\/CD3 (TcR\/CD3) complex","volume":"268","author":"Da Silva","year":"1993","journal-title":"J. Biol. 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Cell Biol."},{"key":"2023072902204258600_Gertleretal1996","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0092-8674(00)81341-0","article-title":"Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics","volume":"87","author":"Gertler","year":"1996","journal-title":"Cell."},{"key":"2023072902204258600_Grossetal1999","doi-asserted-by":"crossref","first-page":"5963","DOI":"10.1074\/jbc.274.9.5963","article-title":"Tyrosine phosphorylation of SLP-76 is downstream of Syk following stimulation of the collagen receptor in platelets","volume":"274","author":"Gross","year":"1999","journal-title":"J. Biol. Chem."},{"key":"2023072902204258600_Hanetal1997","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1128\/MCB.17.3.1346","article-title":"Lck regulates Vav activation of members of the Rho family of GTPases","volume":"17","author":"Han","year":"1997","journal-title":"Mol. Cell. 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Today."},{"key":"2023072902204258600_Kreftetal1995","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1574-6968.1995.tb07403.x","article-title":"The actin-polymerization protein from Listeria ivanovii is a large repeat protein which shows only limited amino acid sequence homology to ActA from Listeria monocytogenes","volume":"126","author":"Kreft","year":"1995","journal-title":"FEMS Microbiol. Lett."},{"key":"2023072902204258600_Kupferetal1987","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1084\/jem.165.6.1565","article-title":"The specific interaction of helper T cells and antigen-presenting B cells","volume":"165","author":"Kupfer","year":"1987","journal-title":"J. Exp. Med."},{"key":"2023072902204258600_Kupferetal1991","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1073\/pnas.88.3.775","article-title":"Polarized expression of cytokines in cell conjugates of helper T-cells and splenic B cells","volume":"88","author":"Kupfer","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072902204258600_Lanieretal1999","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0896-6273(00)81092-2","article-title":"Mena is required for neurulation and commissure formation","volume":"22","author":"Lanier","year":"1999","journal-title":"Neuron."},{"key":"2023072902204258600_LanzavecchiaandScheidegger1987","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/eji.1830170118","article-title":"The use of hybrid hybridomas to target human cytotoxic T lymphocytes","volume":"17","author":"Lanzavecchia","year":"1987","journal-title":"Eur. J. Immunol."},{"key":"2023072902204258600_Lasaetal1995","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.1365-2958.1995.mmi_18030425.x","article-title":"The amino-terminal part of ActA is critical for the actin-based motility of Listeria monocytogenes; the central proline-rich region acts as a stimulator","volume":"18","author":"Lasa","year":"1995","journal-title":"Mol. Microbiol."},{"key":"2023072902204258600_Lasaetal1997","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1093\/emboj\/16.7.1531","article-title":"Identification of two regions in the N-terminal domain of ActA involved in the actin comet tail formation by Listeria monocytogenes","volume":"16","author":"Lasa","year":"1997","journal-title":"EMBO (Eur. Mol. Biol. Organ.) J."},{"key":"2023072902204258600_Laurentetal1999","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1083\/jcb.144.6.1245","article-title":"Role of proteins of the Ena\/VASP family in actin-based motility of Listeria monocytogenes","volume":"144","author":"Laurent","year":"1999","journal-title":"J. Cell Biol."},{"key":"2023072902204258600_Loiseletal1999","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/44183","article-title":"Reconstitution of actin-based motility of Listeria and Shigella using pure proteins","volume":"401","author":"Loisel","year":"1999","journal-title":"Nature."},{"key":"2023072902204258600_Lowin-Kropfetal1998","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1083\/jcb.140.4.861","article-title":"Cytoskeletal polarization of T-cells is regulated by an immunoreceptor tyrosine-based activation motif-dependent mechanism","volume":"140","author":"Lowin-Kropf","year":"1998","journal-title":"J. Cell Biol."},{"key":"2023072902204258600_Macalmaetal1996","doi-asserted-by":"crossref","first-page":"31470","DOI":"10.1074\/jbc.271.49.31470","article-title":"Molecular characterization of human zyxin","volume":"271","author":"Macalma","year":"1996","journal-title":"J. Biol. Chem."},{"key":"2023072902204258600_MacheskyandInsall1998","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/S0960-9822(98)00015-3","article-title":"Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2\/3 complex","volume":"8","author":"Machesky","year":"1998","journal-title":"Curr. Biol."},{"key":"2023072902204258600_Macheskyetal1997","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1042\/bj3280105","article-title":"Mammalian actin-related 2\/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionary conserved proteins","volume":"328","author":"Machesky","year":"1997","journal-title":"Biochem. J."},{"key":"2023072902204258600_Macheskyetal1999","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.1073\/pnas.96.7.3739","article-title":"Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2\/3 complex","volume":"96","author":"Machesky","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072902204258600_Mayetal1999","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0960-9822(99)80337-6","article-title":"The Arp2\/3 complex is essential for the actin-based motility of Listeria monocytogenes","volume":"9","author":"May","year":"1999","journal-title":"Curr. Biol."},{"key":"2023072902204258600_Mottoetal1994","doi-asserted-by":"crossref","first-page":"21608","DOI":"10.1016\/S0021-9258(17)31848-3","article-title":"In vivo association of Grb2 with pp116, a substrate of the T cell antigen receptor-activated protein tyrosine kinase","volume":"269","author":"Motto","year":"1994","journal-title":"J. Biol. Chem."},{"key":"2023072902204258600_Mottoetal1996","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1084\/jem.183.4.1937","article-title":"Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production","volume":"183","author":"Motto","year":"1996","journal-title":"J. Exp. Med."},{"key":"2023072902204258600_Muscietal1997","doi-asserted-by":"crossref","first-page":"11674","DOI":"10.1074\/jbc.272.18.11674","article-title":"Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases","volume":"272","author":"Musci","year":"1997","journal-title":"J. Biol. Chem."},{"key":"2023072902204258600_Niebuhretal1993","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1128\/iai.61.7.2793-2802.1993","article-title":"Localization of the ActA polypeptide of Listeria monocytogenes in infected tissue culture cell linesActA is not associated with actin comets","volume":"61","author":"Niebuhr","year":"1993","journal-title":"Infect. Immun."},{"key":"2023072902204258600_Niebuhretal1997","doi-asserted-by":"crossref","first-page":"5433","DOI":"10.1093\/emboj\/16.17.5433","article-title":"A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena\/VASP family","volume":"16","author":"Niebuhr","year":"1997","journal-title":"EMBO (Eur. Mol. Biol. Organ.) 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Biol."},{"key":"2023072902204258600_PantaloniandCarlier1993","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/0092-8674(93)90544-Z","article-title":"How profilin promotes actin filament assembly in the presence of thymosin \u03b24","volume":"75","author":"Pantaloni","year":"1993","journal-title":"Cell."},{"key":"2023072902204258600_PenningerandCrabtree1999","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0092-8674(00)80954-X","article-title":"The actin cytoskeleton and lymphocyte activation","volume":"96","author":"Penninger","year":"1999","journal-title":"Cell."},{"key":"2023072902204258600_Pistoretal1995","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0960-9822(95)00104-7","article-title":"The bacterial actin nucleator protein ActA of Listeria monocytogenes contains multiple binding sites for host microfilament proteins","volume":"5","author":"Pistor","year":"1995","journal-title":"Curr. Biol."},{"key":"2023072902204258600_Raabetal1999","doi-asserted-by":"crossref","first-page":"21170","DOI":"10.1074\/jbc.274.30.21170","article-title":"FYN-T-FYB-SLP-76 interactions define a T-cell receptor zeta\/CD3-mediated tyrosine phosphorylation pathway that up-regulates interleukin 2 transcription in T-cells","volume":"274","author":"Raab","year":"1999","journal-title":"J. Biol. Chem."},{"key":"2023072902204258600_Reinhardetal1992","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1002\/j.1460-2075.1992.tb05264.x","article-title":"The 46\/50 kDa phosphoprotein VASP purified from human platelets is a novel protein associated with actin filaments and focal contacts","volume":"11","author":"Reinhard","year":"1992","journal-title":"EMBO (Eur. Mol. Biol. Organ.) 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Biol."},{"key":"2023072902204258600_Rohatgietal1999","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0092-8674(00)80732-1","article-title":"The interaction between N-WASP and the Arp2\/3 complex links Cdc42-dependent signals to actin assembly","volume":"97","author":"Rohatgi","year":"1999","journal-title":"Cell."},{"key":"2023072902204258600_Rottneretal1999","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/13040","article-title":"VASP dynamics during lamellipodia protrusion","volume":"1","author":"Rottner","year":"1999","journal-title":"Nat. Cell Biol."},{"key":"2023072902204258600_Ryseretal1982","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.4049\/jimmunol.128.3.1159","article-title":"The area of attachment of cytotoxic T lymphocytes to their target cells shows high motility and polarization of actin, but not myosin","volume":"128","author":"Ryser","year":"1982","journal-title":"J. Immun."},{"key":"2023072902204258600_Sadleretal1992","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1083\/jcb.119.6.1573","article-title":"Zyxin and cCRPtwo interactive LIM domain proteins associated with the cytoskeleton","volume":"119","author":"Sadler","year":"1992","journal-title":"J. Cell Biol."},{"key":"2023072902204258600_Sattleretal1995","first-page":"1040","article-title":"The thrombopoietin receptor c-MPL activates JAK2 and TYK2 tyrosine kinases","volume":"23","author":"Sattler","year":"1995","journal-title":"Exp. Hematol."},{"key":"2023072902204258600_Secristetal1993","doi-asserted-by":"crossref","first-page":"5886","DOI":"10.1016\/S0021-9258(18)53403-7","article-title":"Stimulatory effects of the protein tyrosine phosphatase inhibitor, pervanadate, on T-cell activation events","volume":"268","author":"Secrist","year":"1993","journal-title":"J. Biol. Chem."},{"key":"2023072902204258600_Smithetal1996","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1083\/jcb.135.3.647","article-title":"The tandem repeat domain in the Listeria monocytogenes ActA protein controls the rate of actin-based motility, the percentage of moving bacteria, and the localization of vasodilator-stimulated phosphoprotein and profilin","volume":"135","author":"Smith","year":"1996","journal-title":"J. Cell Biol."},{"key":"2023072902204258600_Snapperetal1998","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S1074-7613(00)80590-7","article-title":"Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation","volume":"9","author":"Snapper","year":"1998","journal-title":"Immunity."},{"key":"2023072902204258600_Symonsetal1996","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0092-8674(00)81050-8","article-title":"Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization","volume":"84","author":"Symons","year":"1996","journal-title":"Cell."},{"key":"2023072902204258600_Takuboetal1998","doi-asserted-by":"crossref","first-page":"310","DOI":"10.3109\/10520299809141124","article-title":"Localization of myosin, actin, alpha-actinin, tropomyosin, and vinculin in surface-activated, spreading human platelets","volume":"73","author":"Takubo","year":"1998","journal-title":"Biotech. Histochem."},{"key":"2023072902204258600_Tuostoetal1996","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1084\/jem.184.3.1161","article-title":"p95vav associates with tyrosine-phosphorylated SLP-76 in antigen stimulated T cells","volume":"184","author":"Tuosto","year":"1996","journal-title":"J. Exp. Med."},{"key":"2023072902204258600_Valituttietal1995","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1084\/jem.181.2.577","article-title":"Sustained signaling leading to T-cell activation results from prolonged T-cell receptor occupancy. Role of T-cell actin cytoskeleton","volume":"181","author":"Valitutti","year":"1995","journal-title":"J. Exp. Med."},{"key":"2023072902204258600_VanTroysetal1996","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/j.1460-2075.1996.tb00350.x","article-title":"The actin binding site of thymosin \u03b24 mapped by mutational analysis","volume":"15","author":"Van Troys","year":"1996","journal-title":"EMBO (Eur. Mol. Biol. Organ.) J."},{"key":"2023072902204258600_Vealeetal1999","doi-asserted-by":"crossref","first-page":"28427","DOI":"10.1074\/jbc.274.40.28427","article-title":"Novel isoform of lymphoid adaptor FYN-T-binding protein (FYB-130) interacts with SLP-76 and up-regulates interleukin 2 production","volume":"274","author":"Veale","year":"1999","journal-title":"J. Biol. Chem."},{"key":"2023072902204258600_WatsonandGibbins1998","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0167-5699(98)01267-5","article-title":"Collagen receptor signalling in plateletsextending the role of the ITAM","volume":"19","author":"Watson","year":"1998","journal-title":"Immunol. Today."},{"key":"2023072902204258600_WeissandLittman1994","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0092-8674(94)90334-4","article-title":"Signal transduction by lymphocyte antigen receptors","volume":"76","author":"Weiss","year":"1994","journal-title":"Cell."},{"key":"2023072902204258600_Welchetal1997a","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/385265a0","article-title":"Actin polymerization is induced by Arp2\/3 protein complex at the surface of Listeria monocytogenes","volume":"385","author":"Welch","year":"1997","journal-title":"Nature."},{"key":"2023072902204258600_Welchetal1997b","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1083\/jcb.138.2.375","article-title":"The human Arp2\/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly","volume":"138","author":"Welch","year":"1997","journal-title":"J. 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Biol."},{"key":"2023072902204258600_Xavieretal1998","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S1074-7613(00)80577-4","article-title":"Membrane compartmentation is required for efficient T cell activation","volume":"8","author":"Xavier","year":"1998","journal-title":"Immunity."},{"key":"2023072902204258600_Yararetal1999","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0960-9822(99)80243-7","article-title":"The Wiskott-Aldrich syndrome protein directs actin-based motility by stimulating actin nucleation with the Arp2\/3 complex","volume":"9","author":"Yarar","year":"1999","journal-title":"Curr. 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