{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:00:39Z","timestamp":1791302439557,"version":"4.1.0"},"reference-count":59,"publisher":"Rockefeller University Press","issue":"6","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,3,19]]},"abstract":"<jats:p>Muscle fibers attach to laminin in the basal lamina using two distinct mechanisms: the dystrophin glycoprotein complex and the \u03b17\u03b21 integrin. Defects in these linkage systems result in Duchenne muscular dystrophy (DMD), \u03b12 laminin congenital muscular dystrophy, sarcoglycan-related muscular dystrophy, and \u03b17 integrin congenital muscular dystrophy. Therefore, the molecular continuity between the extracellular matrix and cell cytoskeleton is essential for the structural and functional integrity of skeletal muscle. To test whether the \u03b17\u03b21 integrin can compensate for the absence of dystrophin, we expressed the rat \u03b17 chain in mdx\/utr\u2212\/\u2212 mice that lack both dystrophin and utrophin. These mice develop a severe muscular dystrophy highly akin to that in DMD, and they also die prematurely. Using the muscle creatine kinase promoter, expression of the \u03b17BX2 integrin chain was increased 2.0\u20132.3-fold in mdx\/utr\u2212\/\u2212 mice. Concomitant with the increase in the \u03b17 chain, its heterodimeric partner, \u03b21D, was also increased in the transgenic animals. Transgenic expression of the \u03b17BX2 chain in the mdx\/utr\u2212\/\u2212 mice extended their longevity by threefold, reduced kyphosis and the development of muscle disease, and maintained mobility and the structure of the neuromuscular junction. Thus, bolstering \u03b17\u03b21 integrin\u2013mediated association of muscle cells with the extracellular matrix alleviates many of the symptoms of disease observed in mdx\/utr\u2212\/\u2212 mice and compensates for the absence of the dystrophin- and utrophin-mediated linkage systems. This suggests that enhanced expression of the \u03b17\u03b21 integrin may provide a novel approach to treat DMD and other muscle diseases that arise due to defects in the dystrophin glycoprotein complex. A video that contrasts kyphosis, gait, joint contractures, and mobility in mdx\/utr\u2212\/\u2212 and \u03b17BX2-mdx\/utr\u2212\/\u2212mice can be accessed at http:\/\/www.jcb.org\/cgi\/content\/full\/152\/6\/1207.<\/jats:p>","DOI":"10.1083\/jcb.152.6.1207","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T12:46:23Z","timestamp":1027687583000},"page":"1207-1218","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":235,"title":["Enhanced Expression of the \u03b17\u03b21 Integrin Reduces Muscular Dystrophy and Restores Viability in Dystrophic Mice"],"prefix":"10.1083","volume":"152","author":[{"given":"Dean J.","family":"Burkin","sequence":"first","affiliation":[{"name":"aDepartment of Cell and Structural Biology, University of Illinois, Urbana, Illinois 61801"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory Q.","family":"Wallace","sequence":"additional","affiliation":[{"name":"aDepartment of Cell and Structural Biology, University of Illinois, Urbana, Illinois 61801"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly J.","family":"Nicol","sequence":"additional","affiliation":[{"name":"aDepartment of Cell and Structural Biology, University of Illinois, Urbana, Illinois 61801"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Kaufman","sequence":"additional","affiliation":[{"name":"bNational Cancer Institute, Bethesda, Maryland 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Kaufman","sequence":"additional","affiliation":[{"name":"aDepartment of Cell and Structural Biology, University of Illinois, Urbana, Illinois 61801"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2001,3,19]]},"reference":[{"key":"2026010916070740400_AmalfitanoandChamberlain1996","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1002\/(SICI)1097-4598(199612)19:12<1549::AID-MUS4>3.0.CO;2-A","article-title":"The mdx-amplification-resistant mutation system assay, a simple and rapid polymerase chain reaction-based detection of the mdx allele","volume":"19","author":"Amalfitano","year":"1996","journal-title":"Muscle Nerve."},{"key":"2026010916070740400_Belkinetal1996","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1083\/jcb.132.1.211","article-title":"Beta 1D integrin displaces the beta 1A isoform in striated muscleslocalization at junctional structures and signaling potential in nonmuscle cells","volume":"132","author":"Belkin","year":"1996","journal-title":"J. Cell Biol."},{"key":"2026010916070740400_Belkinetal1997","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1083\/jcb.139.6.1583","article-title":"Muscle beta1D integrin reinforces the cytoskeleton\u2013matrix linkmodulation of integrin adhesive function by alternative splicing","volume":"139","author":"Belkin","year":"1997","journal-title":"J. Cell Biol."},{"key":"2026010916070740400_Bertorinietal1982","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1212\/WNL.32.10.1088","article-title":"Muscle calcium and magnesium content in Duchenne muscular dystrophy","volume":"32","author":"Bertorini","year":"1982","journal-title":"Neurology."},{"key":"2026010916070740400_Bulfieldetal1984","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1073\/pnas.81.4.1189","article-title":"X chromosome-linked muscular dystrophy (mdx) in the mouse","volume":"81","author":"Bulfield","year":"1984","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2026010916070740400_BurkinandKaufman1999","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s004410051279","article-title":"The \u03b17\u03b21 integrin in muscle development and disease","volume":"296","author":"Burkin","year":"1999","journal-title":"Cell Tissue Res."},{"key":"2026010916070740400_Burkinetal1998","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1083\/jcb.143.4.1067","article-title":"A functional role for specific spliced variants of the \u03b17\u03b21 integrin in acetylcholine receptor clustering","volume":"143","author":"Burkin","year":"1998","journal-title":"J. Cell Biol"},{"key":"2026010916070740400_Burkinetal2000","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1242\/jcs.113.16.2877","article-title":"Laminin and \u03b17\u03b21 integrin regulate agrin-induced clustering of acetylcholine receptors","volume":"113","author":"Burkin","year":"2000","journal-title":"J. Cell Sci"},{"key":"2026010916070740400_Campbell1995","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/0092-8674(95)90344-5","article-title":"Three muscular dystrophiesloss of cytoskeleton-extracellular matrix linkage","volume":"80","author":"Campbell","year":"1995","journal-title":"Cell"},{"key":"2026010916070740400_Colloetal1993","doi-asserted-by":"crossref","first-page":"19019","DOI":"10.1016\/S0021-9258(17)46729-9","article-title":"A new isoform of the laminin receptor integrin alpha 7 beta 1 is developmentally regulated in skeletal muscle","volume":"268","author":"Collo","year":"1993","journal-title":"J. Biol. Chem"},{"key":"2026010916070740400_Colognatoetal1999","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1083\/jcb.145.3.619","article-title":"Laminin polymerization induces a receptor\u2013cytoskeleton network","volume":"145","author":"Colognato","year":"1999","journal-title":"J. Cell Biol."},{"key":"2026010916070740400_Conover1980","volume-title":"Practical Nonparametric Statistics","author":"Conover","year":"1980","edition":"2nd ed"},{"key":"2026010916070740400_Deconincketal1997a","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1083\/jcb.136.4.883","article-title":"Postsynaptic abnormalities at the neuromuscular junctions of utrophin-deficient mice","volume":"136","author":"Deconinck","year":"1997","journal-title":"J. Cell Biol"},{"key":"2026010916070740400_Deconincketal1997b","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0092-8674(00)80532-2","article-title":"Utrophin-dystrophin deficient mice as a model for Duchenne muscular dystrophy","volume":"90","author":"Deconinck","year":"1997","journal-title":"Cell."},{"key":"2026010916070740400_Denetclawetal1994","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1091\/mbc.5.10.1159","article-title":"Myotubes from transgenic mdx mice expressing full-length dystrophin show normal calcium regulation","volume":"5","author":"Denetclaw","year":"1994","journal-title":"Mol. Biol. Cell"},{"key":"2026010916070740400_DiMarioetal1991","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/0012-1606(91)90340-9","article-title":"Fiber regeneration is not persistent in dystrophic (mdx) mouse skeletal muscle","volume":"148","author":"DiMario","year":"1991","journal-title":"Dev. Biol."},{"key":"2026010916070740400_Donovieletal1996","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1128\/MCB.16.4.1649","article-title":"Analysis of muscle creatine kinase gene regulatory elements in skeletal and cardiac muscles of transgenic mice","volume":"16","author":"Donoviel","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"2026010916070740400_Gradyetal1997a","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1083\/jcb.136.4.871","article-title":"Subtle neuromuscular defects in utrophin-deficient mice","volume":"136","author":"Grady","year":"1997","journal-title":"J. Cell Biol"},{"key":"2026010916070740400_Gradyetal1997b","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/S0092-8674(00)80533-4","article-title":"Skeletal and cardiac myopathies in mice lacking utrophin and dystrophina model for Duchenne muscular dystrophy","volume":"90","author":"Grady","year":"1997","journal-title":"Cell"},{"key":"2026010916070740400_Gradyetal1999","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/12034","article-title":"Role for alpha-dystrobrevin in the pathogenesis of dystrophin-dependent muscular dystrophies","volume":"1","author":"Grady","year":"1999","journal-title":"Nat. Cell Biol."},{"key":"2026010916070740400_N0x2851a50N0x2f581b0","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0022-510X(93)90191-Z","article-title":"Abnormal localization of laminin subunits in muscular dystrophies","volume":"119","author":"Hayashi","year":"1993","journal-title":"J. Neurol. Sci"},{"key":"2026010916070740400_Hayashietal1998","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/ng0598-94","article-title":"Mutations in the integrin \u03b17 gene cause congenital myopathy","volume":"19","author":"Hayashi","year":"1998","journal-title":"Nat. Genet"},{"key":"2026010916070740400_HodgesandKaufman1996","first-page":"437","article-title":"Developmental regulation and functional significance of alternative splicing of NCAM and \u03b17\u03b21 integrin in skeletal muscle","volume":"6","author":"Hodges","year":"1996","journal-title":"Basic Appl. Myol"},{"key":"2026010916070740400_Hodgesetal1997","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1242\/jcs.110.22.2873","article-title":"Altered expression of the \u03b17\u03b21 integrin in human and murine muscular dystrophies","volume":"110","author":"Hodges","year":"1997","journal-title":"J. Cell Sci"},{"key":"2026010916070740400_Hynes1992","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0092-8674(92)90115-S","article-title":"Integrinsversatility, modulation, and signaling in cell adhesion","volume":"69","author":"Hynes","year":"1992","journal-title":"Cell."},{"key":"2026010916070740400_Jaynesetal1986","first-page":"2855","article-title":"Transcriptional regulation of the muscle creatine kinase gene and related expression in transfected mouse myoblasts","volume":"6","author":"Jaynes","year":"1986","journal-title":"Mol. Cell. Biol"},{"key":"2026010916070740400_Johnsonetal1989","first-page":"3393","article-title":"Muscle creatine kinase sequence elements regulating skeletal and cardiac muscle expression in transgenic mice","volume":"9","author":"Johnson","year":"1989","journal-title":"Mol. Cell. Biol"},{"key":"2026010916070740400_KaplanandMeier1958","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Nonparametric estimation from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J. Am. Stat. Assoc"},{"key":"2026010916070740400_Kimetal1999","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3109\/15419069909034393","article-title":"Cellular localization of \u03b13\u03b21 integrin isoforms in association with myofibrillogenesis during cardiac myocyte development in culture","volume":"7","author":"Kim","year":"1999","journal-title":"Cell Adhes. Commun."},{"key":"2026010916070740400_Kwonetal2000","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1091\/mbc.11.4.1433","article-title":"Calreticulin couples calcium release and calcium influx in \u03b17\u03b21 integrin-mediated calcium signaling","volume":"11","author":"Kwon","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"2026010916070740400_Lawetal1994","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1242\/jcs.107.6.1477","article-title":"Talin, vinculin and DRP (utrophin) concentrations are increased at the mdx myotendinous junctions following onset of necrosis","volume":"107","author":"Law","year":"1994","journal-title":"J. Cell Sci"},{"key":"2026010916070740400_Leungetal1998","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1006\/bbrc.1998.8092","article-title":"A novel extracellular domain variant of the human integrin \u03b17 subunit generated by alternative intron splicing","volume":"243","author":"Leung","year":"1998","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"2026010916070740400_LimandCampbell1998","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1097\/00019052-199810000-00006","article-title":"The sarcoglycan complex in limb-girdle muscular dystrophy","volume":"11","author":"Lim","year":"1998","journal-title":"Curr. Opin. Neurol."},{"key":"2026010916070740400_Martinetal1996","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1006\/dbio.1996.0057","article-title":"Synaptic integrinsselective association of the \u03b11 and \u03b17A, and \u03b17B subunits with the neuromuscular junction","volume":"174","author":"Martin","year":"1996","journal-title":"Dev. Biol"},{"key":"2026010916070740400_Matsudaetal1983","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/0012-1606(83)90240-3","article-title":"Regenerating adult chicken skeletal muscle and satellite cell cultures express embryonic patterns of myosin and tropomyosin isoforms","volume":"100","author":"Matsuda","year":"1983","journal-title":"Dev. Biol."},{"key":"2026010916070740400_MatsumuraandCampbell1994","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/mus.880170103","article-title":"Dystrophin-glycoprotein complexits role in the molecular pathogenesis of muscular dystrophies","volume":"17","author":"Matsumura","year":"1994","journal-title":"Muscle Nerve"},{"key":"2026010916070740400_Matsumuraetal1992","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/360588a0","article-title":"Association of dystrophin-related protein with dystrophin-associated proteins in mdx mouse muscle","volume":"360","author":"Matsumura","year":"1992","journal-title":"Nature."},{"key":"2026010916070740400_Mayeretal1997","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/ng1197-318","article-title":"Absence of integrin alpha 7 causes a novel form of muscular dystrophy","volume":"17","author":"Mayer","year":"1997","journal-title":"Nat. Genet"},{"key":"2026010916070740400_Monacoetal1986","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/323646a0","article-title":"Isolation of candidate cDNAs for portions of the Duchenne muscular dystrophy gene","volume":"323","author":"Monaco","year":"1986","journal-title":"Nature."},{"key":"2026010916070740400_Odaetal1993","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1097\/01241398-199307000-00012","article-title":"Longitudinal study of spinal deformity in Duchenne muscular dystrophy","volume":"13","author":"Oda","year":"1993","journal-title":"J. Pediatr. Orthop."},{"key":"2026010916070740400_Petoetal1977","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/bjc.1977.1","article-title":"Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples","volume":"35","author":"Peto","year":"1977","journal-title":"Brit. J. Cancer"},{"key":"2026010916070740400_Ponsetal1994","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/0022-510X(94)90295-X","article-title":"Does utrophin expression in muscles of mdx mice during postnatal development functionally compensate for dystrophin deficiency","volume":"122","author":"Pons","year":"1994","journal-title":"J. Neurol. Sci"},{"key":"2026010916070740400_Rafaeletal1998","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/ng0598-79","article-title":"Skeletal muscle-specific expression of a utrophin transgene rescues utrophin-dystrophin deficient mice","volume":"19","author":"Rafael","year":"1998","journal-title":"Nat. Genet"},{"key":"2026010916070740400_Rafaeletal2000","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1093\/hmg\/9.9.1357","article-title":"Dystrophin and utrophin influence fiber type composition and post-synaptic membrane structure","volume":"9","author":"Rafael","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"2026010916070740400_Saadetal1987","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/0012-1606(87)90039-X","article-title":"Immunochemical analysis of protein isoforms in thick myofilaments of regenerating skeletal muscle","volume":"119","author":"Saad","year":"1987","journal-title":"Dev. Biol."},{"key":"2026010916070740400_SaherandHildt1999","doi-asserted-by":"crossref","first-page":"27651","DOI":"10.1074\/jbc.274.39.27651","article-title":"Activation of c-Raf-1 kinase signal transduction pathway in alpha(7) integrin-deficient mice","volume":"274","author":"Saher","year":"1999","journal-title":"J. Biol. Chem."},{"key":"2026010916070740400_Sambrooketal1989","volume-title":"Molecular CloningA Laboratory Manual. 2nd ed., Vol. 2","author":"Sambrook","year":"1989"},{"key":"2026010916070740400_Shieldetal1996","doi-asserted-by":"crossref","first-page":"5058","DOI":"10.1128\/MCB.16.9.5058","article-title":"E-box sites and a proximal regulatory region of the muscle creatine kinase gene differentially regulate expression in diverse skeletal muscles and cardiac muscle of transgenic mice","volume":"16","author":"Shield","year":"1996","journal-title":"Mol. Cell. Biol"},{"key":"2026010916070740400_Sicinskietal1989","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1126\/science.2662404","article-title":"The molecular basis of muscular dystrophy in the mdx mousea point mutation","volume":"244","author":"Sicinski","year":"1989","journal-title":"Science."},{"key":"2026010916070740400_Songetal1992","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1083\/jcb.117.3.643","article-title":"H36-\u03b17 is a novel integrin alpha chain that is developmentally regulated during skeletal myogenesis","volume":"117","author":"Song","year":"1992","journal-title":"J. Cell Biol."},{"key":"2026010916070740400_Songetal1993","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1242\/jcs.106.4.1139","article-title":"Expression of \u03b17 integrin cytoplasmic domains during skeletal muscle developmentalternate forms, conformational change, and homologies with serine\/threonine kinases and tyrosine phosphatases","volume":"106","author":"Song","year":"1993","journal-title":"J. Cell Sci."},{"key":"2026010916070740400_Tinsleyetal1996","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/384349a0","article-title":"Amelioration of the dystrophic phenotype of mdx mice using a truncated utrophin transgene","volume":"384","author":"Tinsley","year":"1996","journal-title":"Nature."},{"key":"2026010916070740400_Turneretal1988","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/335735a0","article-title":"Increased protein degradation results from elevated free calcium levels found in muscle from mdx mice","volume":"335","author":"Turner","year":"1988","journal-title":"Nature."},{"key":"2026010916070740400_vanderFlieretal1995","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/0014-5793(95)00814-P","article-title":"A novel beta 1 integrin isoform produced by alternative splicingunique expression in cardiac and skeletal muscle","volume":"369","author":"van der Flier","year":"1995","journal-title":"FEBS Lett"},{"key":"2026010916070740400_Vignieretal1999","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1006\/bbrc.1999.0916","article-title":"Structure, genetic localization, and identification of the cardiac and skeletal muscle transcripts of the human integrin alpha 7 gene (ITGA)","volume":"260","author":"Vignier","year":"1999","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"2026010916070740400_vonderMarketal1991","doi-asserted-by":"crossref","first-page":"23593","DOI":"10.1016\/S0021-9258(18)54324-6","article-title":"Skeletal myoblasts utilize a novel \u03b11-series integrin and not \u03b16\u03b21 for binding to the E8 and T8 fragments of laminin","volume":"266","author":"von der Mark","year":"1991","journal-title":"J. Biol. Chem."},{"key":"2026010916070740400_Wangetal1995","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/0888-7543(95)80176-M","article-title":"Localization of the \u03b17 integrin gene (ITGA7) on human chromosome 12q13Clustering of integrin and hox genes implies parallel evolution of these gene families","volume":"26","author":"Wang","year":"1995","journal-title":"Genomics."},{"key":"2026010916070740400_Zhidkovaetal1995","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1006\/bbrc.1995.2285","article-title":"Novel isoform of beta 1 integrin expressed in skeletal and cardiac muscle","volume":"214","author":"Zhidkova","year":"1995","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"2026010916070740400_Zioberetal1993","doi-asserted-by":"crossref","first-page":"26773","DOI":"10.1016\/S0021-9258(19)74380-4","article-title":"Alternative extracellular and cytoplasmic domains of the integrin \u03b17 subunit are differentially expressed during development","volume":"268","author":"Ziober","year":"1993","journal-title":"J. Biol. Chem."}],"container-title":["The Journal of Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/152\/6\/1207\/1510108\/0010131.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jcb\/article-pdf\/152\/6\/1207\/1510108\/0010131.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T21:07:18Z","timestamp":1767992838000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jcb\/article\/152\/6\/1207\/45834\/Enhanced-Expression-of-the-7-1-Integrin-Reduces"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,3,19]]},"references-count":59,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2001,3,19]]}},"URL":"https:\/\/doi.org\/10.1083\/jcb.152.6.1207","relation":{},"ISSN":["0021-9525","1540-8140"],"issn-type":[{"value":"0021-9525","type":"print"},{"value":"1540-8140","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,3,19]]}}}