{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T06:08:20Z","timestamp":1791007700094,"version":"4.1.0"},"reference-count":60,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,5,14]]},"abstract":"<jats:p>Laminin 5 is a basement membrane component that actively promotes adhesion and migration of epithelial cells. Laminin 5 undergoes extracellular proteolysis of the \u03b32 chain that removes the NH2-terminal short arm of the polypeptide and reduces the size of laminin 5 from 440 to 400 kD. The functional consequence of this event remains obscure, although lines of evidence indicate that cleavage of the \u03b32 chain potently stimulated scattering and migration of keratinocytes and cancer cells. To define the biological role of the \u03b32 chain short arm, we expressed mutated \u03b32 cDNAs into immortalized \u03b32-null keratinocytes. By immunofluorescence and immunohistochemical studies, cell detachment, and adhesion assays, we found that the \u03b32 short arm drives deposition of laminin 5 into the extracellular matrix (ECM) and sustains cell adhesion. Our results demonstrate that the unprocessed 440-kD form of laminin 5 is a biologically active adhesion ligand, and that the \u03b32 globular domain IV is involved in intermolecular interactions that mediate integration of laminin 5 in the ECM and cell attachment.<\/jats:p>","DOI":"10.1083\/jcb.153.4.835","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:46:23Z","timestamp":1027701983000},"page":"835-850","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":106,"title":["The Short Arm of the Laminin \u03b32 Chain Plays a Pivotal Role in the Incorporation of Laminin 5 into the Extracellular Matrix and in Cell Adhesion"],"prefix":"10.1083","volume":"153","author":[{"given":"Laurent","family":"Gagnoux-Palacios","sequence":"first","affiliation":[{"name":"aFaculty of Medicine, U385 Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Cedex 2, 06107 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryline","family":"Allegra","sequence":"additional","affiliation":[{"name":"aFaculty of Medicine, U385 Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Cedex 2, 06107 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Spirito","sequence":"additional","affiliation":[{"name":"aFaculty of Medicine, U385 Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Cedex 2, 06107 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Pommeret","sequence":"additional","affiliation":[{"name":"aFaculty of Medicine, U385 Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Cedex 2, 06107 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Romero","sequence":"additional","affiliation":[{"name":"aFaculty of Medicine, U385 Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Cedex 2, 06107 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-paul","family":"Ortonne","sequence":"additional","affiliation":[{"name":"bDermatology Service, L'Archet Hospital, Cedex 3, 06202 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guerrino","family":"Meneguzzi","sequence":"additional","affiliation":[{"name":"aFaculty of Medicine, U385 Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Cedex 2, 06107 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2001,5,14]]},"reference":[{"key":"2023072211390621500_Aberdametal1994a","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/ng0394-299","article-title":"Herlitz's junctional epidermolysis bullosa is genetically linked to mutations in the nicein\/kalinin (laminin 5) LAMC2 gene","volume":"6","author":"Aberdam","year":"1994","journal-title":"Nat. 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