{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:00:11Z","timestamp":1791288011869,"version":"4.3.0"},"reference-count":46,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,8,20]]},"abstract":"<jats:p>We show here that the \u03b1, \u03b2, and \u03b3 isotypes of peroxisome proliferator\u2013activated receptor (PPAR) are expressed in the mouse epidermis during fetal development and that they disappear progressively from the interfollicular epithelium after birth. Interestingly, PPAR\u03b1 and \u03b2 expression is reactivated in the adult epidermis after various stimuli, resulting in keratinocyte proliferation and differentiation such as tetradecanoylphorbol acetate topical application, hair plucking, or skin wound healing. Using PPAR\u03b1, \u03b2, and \u03b3 mutant mice, we demonstrate that PPAR\u03b1 and \u03b2 are important for the rapid epithelialization of a skin wound and that each of them plays a specific role in this process. PPAR\u03b1 is mainly involved in the early inflammation phase of the healing, whereas PPAR\u03b2 is implicated in the control of keratinocyte proliferation. In addition and very interestingly, PPAR\u03b2 mutant primary keratinocytes show impaired adhesion and migration properties. Thus, the findings presented here reveal unpredicted roles for PPAR\u03b1 and \u03b2 in adult mouse epidermal repair.<\/jats:p>","DOI":"10.1083\/jcb.200011148","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:46:23Z","timestamp":1027701983000},"page":"799-814","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":353,"title":["Impaired skin wound healing in peroxisome proliferator\u2013activated receptor (PPAR)<b>\u03b1<\/b> and PPAR<b>\u03b2<\/b> mutant mice"],"prefix":"10.1083","volume":"154","author":[{"given":"Liliane","family":"Michalik","sequence":"first","affiliation":[{"name":"1Institut de Biologie Animale, Universite\u0301 de Lausanne, Ba\u0302timent de Biologie, CH-1015 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Be\u0301atrice","family":"Desvergne","sequence":"additional","affiliation":[{"name":"1Institut de Biologie Animale, Universite\u0301 de Lausanne, Ba\u0302timent de Biologie, CH-1015 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguan Soon","family":"Tan","sequence":"additional","affiliation":[{"name":"1Institut de Biologie Animale, Universite\u0301 de Lausanne, Ba\u0302timent de Biologie, CH-1015 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharmila","family":"Basu-Modak","sequence":"additional","affiliation":[{"name":"1Institut de Biologie Animale, Universite\u0301 de Lausanne, Ba\u0302timent de Biologie, CH-1015 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Escher","sequence":"additional","affiliation":[{"name":"1Institut de Biologie Animale, Universite\u0301 de Lausanne, Ba\u0302timent de Biologie, CH-1015 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Rieusset","sequence":"additional","affiliation":[{"name":"1Institut de Biologie Animale, Universite\u0301 de Lausanne, Ba\u0302timent de Biologie, CH-1015 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Peters","sequence":"additional","affiliation":[{"name":"3Laboratory of Molecular Carcinogenesis, National Cancer Institute, National Institute of Health, Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gu\u0308rkan","family":"Kaya","sequence":"additional","affiliation":[{"name":"2Department of Dermatology, University Hospital of Geneva, CH-1212 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank J.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"3Laboratory of Molecular Carcinogenesis, National Cancer Institute, National Institute of Health, Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jozsef","family":"Zakany","sequence":"additional","affiliation":[{"name":"4De\u0301partement de Zoologie, Universite\u0301 de Gene\u0300ve, Sciences III, CH-1211 Geneva 4, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Metzger","sequence":"additional","affiliation":[{"name":"5Institut de Ge\u0301ne\u0301tique et de Biologie Mole\u0301culaire et Cellulaire, Centre National de la Recherche Scientifique\/Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale\/ULP\/Colle\u0300ge de France, 67404 Illkirch Cedex, CU de Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Chambon","sequence":"additional","affiliation":[{"name":"5Institut de Ge\u0301ne\u0301tique et de Biologie Mole\u0301culaire et Cellulaire, Centre National de la Recherche Scientifique\/Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale\/ULP\/Colle\u0300ge de France, 67404 Illkirch Cedex, CU de Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Duboule","sequence":"additional","affiliation":[{"name":"4De\u0301partement de Zoologie, Universite\u0301 de Gene\u0300ve, Sciences III, CH-1211 Geneva 4, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Wahli","sequence":"additional","affiliation":[{"name":"1Institut de Biologie Animale, Universite\u0301 de Lausanne, Ba\u0302timent de Biologie, CH-1015 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2001,8,20]]},"reference":[{"key":"2023072904361141800_BIB1","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1203\/00006450-199204000-00002","volume":"31","year":"1992","journal-title":"Pediatr. 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