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Similar results were obtained in cultures of chicken spinal cord motoneurons treated with brain-derived neurotrophic factor (BDNF). Moreover, CaM inhibition prevented the cell survival triggered by NGF or BDNF. This effect was counteracted by the transient expression of constitutive active forms of the PKB, indicating that CaM regulates NT-induced cell survival through the activation of the PKB. We have investigated the mechanisms whereby CaM regulates the activation of the PKB, and we have found that CaM was necessary for the proper generation and\/or accumulation of the products of the PI 3-kinase in intact cells.<\/jats:p>","DOI":"10.1083\/jcb.200101023","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:46:23Z","timestamp":1027701983000},"page":"585-598","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":47,"title":["Neuronal survival induced by neurotrophins requires calmodulin"],"prefix":"10.1083","volume":"154","author":[{"given":"Joaquim","family":"Egea","sequence":"first","affiliation":[{"name":"1Grup de Neurobiologia Molecular, Departament de Cie\u0300ncies Me\u0300diques Ba\u0300siques, Facultat de Medicina, Universitat de Lleida, 25198 Lleida, Catalonia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carme","family":"Espinet","sequence":"additional","affiliation":[{"name":"1Grup de Neurobiologia Molecular, Departament de Cie\u0300ncies Me\u0300diques Ba\u0300siques, Facultat de Medicina, Universitat de Lleida, 25198 Lleida, Catalonia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa M.","family":"Soler","sequence":"additional","affiliation":[{"name":"1Grup de Neurobiologia Molecular, Departament de Cie\u0300ncies Me\u0300diques Ba\u0300siques, Facultat de Medicina, Universitat de Lleida, 25198 Lleida, Catalonia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Dolcet","sequence":"additional","affiliation":[{"name":"1Grup de Neurobiologia Molecular, Departament de Cie\u0300ncies Me\u0300diques Ba\u0300siques, Facultat de Medicina, Universitat de Lleida, 25198 Lleida, Catalonia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vi\u0301ctor J.","family":"Yuste","sequence":"additional","affiliation":[{"name":"1Grup de Neurobiologia Molecular, Departament de Cie\u0300ncies Me\u0300diques Ba\u0300siques, Facultat de Medicina, Universitat de Lleida, 25198 Lleida, Catalonia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Encinas","sequence":"additional","affiliation":[{"name":"1Grup de Neurobiologia Molecular, Departament de Cie\u0300ncies Me\u0300diques Ba\u0300siques, Facultat de Medicina, Universitat de Lleida, 25198 Lleida, Catalonia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montserrat","family":"Iglesias","sequence":"additional","affiliation":[{"name":"1Grup de Neurobiologia Molecular, Departament de Cie\u0300ncies Me\u0300diques Ba\u0300siques, Facultat de Medicina, Universitat de Lleida, 25198 Lleida, Catalonia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nativitat","family":"Rocamora","sequence":"additional","affiliation":[{"name":"2Laboratori de Biologia Molecular, Institut Catala\u0300 d'Oncologia, Barcelona, Catalonia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan X.","family":"Comella","sequence":"additional","affiliation":[{"name":"1Grup de Neurobiologia Molecular, Departament de Cie\u0300ncies Me\u0300diques Ba\u0300siques, Facultat de Medicina, Universitat de Lleida, 25198 Lleida, Catalonia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[2001,8,6]]},"reference":[{"key":"2023072211475798800_BIB1","doi-asserted-by":"crossref","first-page":"6541","DOI":"10.1002\/j.1460-2075.1996.tb01045.x","volume":"15","year":"1996","journal-title":"EMBO J."},{"key":"2023072211475798800_BIB2","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1046\/j.1432-1327.1998.2510195.x","volume":"251","year":"1998","journal-title":"Eur. 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