{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:34:00Z","timestamp":1791117240771,"version":"4.1.0"},"reference-count":45,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,8,6]]},"abstract":"<jats:p>The murine genome is known to have two keratin 6 (K6) genes, mouse K6 (MK6)a and MK6b. These genes display a complex expression pattern with constitutive expression in the epithelia of oral mucosa, hair follicles, and nail beds. We generated mice deficient for both genes through embryonic stem cell technology. The majority of MK6a\/b\u2212\/\u2212 mice die of starvation within the first two weeks of life. This is due to a localized disintegration of the dorsal tongue epithelium, which results in the build up of a plaque of cell debris that severely impairs feeding. However, \u223c25% of MK6a\/b\u2212\/\u2212 mice survive to adulthood. Remarkably, the surviving MK6a\/b\u2212\/\u2212 mice have normal hair and nails. To our surprise, we discovered MK6 staining both in the hair follicle and the nail bed of MK6a\/b\u2212\/\u2212 mice, indicating the presence of a third MK6 gene. We cloned this previously unknown murine keratin gene and found it to be highly homologous to human K6hf, which is expressed in hair follicles. We therefore termed this gene MK6 hair follicle (MK6hf). The presence of MK6hf in the MK6a\/b\u2212\/\u2212 follicles and nails offers an explanation for the absence of hair and nail defects in MK6a\/b\u2212\/\u2212 animals.<\/jats:p>","DOI":"10.1083\/jcb.200102079","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:46:23Z","timestamp":1027701983000},"page":"619-630","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":94,"title":["Discovery of a novel murine keratin 6 (K6) isoform explains the absence of hair and nail defects in mice deficient for K6a and K6b"],"prefix":"10.1083","volume":"154","author":[{"given":"Sonja M.","family":"Wojcik","sequence":"first","affiliation":[{"name":"1Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary A.","family":"Longley","sequence":"additional","affiliation":[{"name":"1Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis R.","family":"Roop","sequence":"additional","affiliation":[{"name":"1Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030"},{"name":"2Department of Dermatology, Baylor College of Medicine, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2001,8,6]]},"reference":[{"key":"2023072211445531700_BIB1","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1101\/gad.7.7a.1191","volume":"7","year":"1993","journal-title":"Genes Dev."},{"key":"2023072211445531700_BIB2","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1101\/gad.8.24.2964","volume":"8","year":"1994","journal-title":"Genes Dev."},{"key":"2023072211445531700_BIB3","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1046\/j.1432-0436.1996.6120129.x","volume":"61","year":"1996","journal-title":"Differentiation"},{"key":"2023072211445531700_BIB4","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/j.1460-2075.1987.tb04792.x","volume":"6","year":"1987","journal-title":"EMBO J."},{"key":"2023072211445531700_BIB5","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/ng0795-363","volume":"10","year":"1995","journal-title":"Nat. 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