{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:03:15Z","timestamp":1791288195004,"version":"4.3.0"},"reference-count":88,"publisher":"Rockefeller University Press","issue":"1","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":["J Cell Biol"],"published-print":{"date-parts":[[2001,10,1]]},"DOI":"10.1083\/jcb.200103145","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:46:23Z","timestamp":1027701983000},"page":"41-52","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":184,"title":["Dense core secretory vesicles revealed as a dynamic Ca<sup>2<b>+<\/b><\/sup>store in neuroendocrine cells with a vesicle-associated membrane protein aequorin chimaera"],"prefix":"10.1083","volume":"155","author":[{"given":"Kathryn J.","family":"Mitchell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Pinton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aniko","family":"Varadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Tacchetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward K.","family":"Ainscow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tullio","family":"Pozzan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Rizzuto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy A.","family":"Rutter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2001,9,24]]},"reference":[{"key":"2016021216262821000_155.1.41.1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1042\/bj3530175","volume":"353","year":"2001","journal-title":"Biochem. J."},{"key":"2016021216262821000_155.1.41.2","doi-asserted-by":"crossref","unstructured":"Ainscow, E.K., C. Zhao, and G.A. Rutter. 2000. Acute overexpression of lactate dehydrogenase-A perturbs \u03b2 -cell mitochondrial metabolism and insulin secretion. Diabetes. 49:1149\u20131155.","DOI":"10.2337\/diabetes.49.7.1149"},{"key":"2016021216262821000_155.1.41.3","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1748-1716.1982.tb06977.x","volume":"114","year":"1982","journal-title":"Acta. Physiol. Scand."},{"key":"2016021216262821000_155.1.41.4","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/j.1749-6632.1986.tb34534.x","volume":"483","year":"1986","journal-title":"Ann. NY Acad. Sci."},{"key":"2016021216262821000_155.1.41.5","unstructured":"Ashcroft, F.M., and S.J.M. Ashcroft. 1992. Mechanisms of insulin secretion. Insulin, Molecular Biology to Pathology. F.M. Ashcroft and S.J.H. Ashcroft, editors. Oxford University Press, Oxford, NY. 97\u2013150."},{"key":"2016021216262821000_155.1.41.6","doi-asserted-by":"crossref","first-page":"11241","DOI":"10.1073\/pnas.96.20.11241","volume":"96","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2016021216262821000_155.1.41.7","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/361315a0","volume":"361","year":"1993","journal-title":"Nature."},{"key":"2016021216262821000_155.1.41.8","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S0076-6879(89)72015-2","volume":"172","year":"1989","journal-title":"Methods Enzymol."},{"key":"2016021216262821000_155.1.41.9","doi-asserted-by":"crossref","first-page":"7777","DOI":"10.1073\/pnas.91.16.7777","volume":"91","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2016021216262821000_155.1.41.10","doi-asserted-by":"crossref","first-page":"4813","DOI":"10.1002\/j.1460-2075.1993.tb06170.x","volume":"12","year":"1993","journal-title":"EMBO J."},{"key":"2016021216262821000_155.1.41.11","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0955-0674(97)80033-6","volume":"9","year":"1997","journal-title":"Curr. Opin. Cell Biol."},{"key":"2016021216262821000_155.1.41.12","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1152\/physrev.1991.71.1.129","volume":"71","year":"1991","journal-title":"Physiol. Rev."},{"key":"2016021216262821000_155.1.41.13","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1083\/jcb.135.6.1775","volume":"135","year":"1996","journal-title":"J. Cell Biol."},{"key":"2016021216262821000_155.1.41.14","doi-asserted-by":"crossref","first-page":"C530","DOI":"10.1152\/ajpcell.1996.270.2.C530","volume":"270","year":"1996","journal-title":"Am. J. Physiol."},{"key":"2016021216262821000_155.1.41.15","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1042\/bj2480313","volume":"248","year":"1987","journal-title":"Biochem. J."},{"key":"2016021216262821000_155.1.41.16","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1083\/jcb.150.4.905","volume":"150","year":"2000","journal-title":"J. Cell Biol"},{"key":"2016021216262821000_155.1.41.17","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/333093a0","volume":"333","year":"1988","journal-title":"Nature."},{"key":"2016021216262821000_155.1.41.18","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/S0960-9822(00)80104-9","volume":"9","year":"1999","journal-title":"Curr. Biol."},{"key":"2016021216262821000_155.1.41.19","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0303-7207(94)90130-9","volume":"98","year":"1994","journal-title":"Mol. Cell. Endocrinol."},{"key":"2016021216262821000_155.1.41.20","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0014-5793(99)00220-3","volume":"446","year":"1999","journal-title":"FEBS Lett."},{"key":"2016021216262821000_155.1.41.21","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0092-8674(00)81292-1","volume":"84","year":"1996","journal-title":"Cell."},{"key":"2016021216262821000_155.1.41.22","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/S0960-9822(07)00565-9","volume":"8","year":"1998","journal-title":"Curr. Biol."},{"key":"2016021216262821000_155.1.41.23","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0304-3940(98)00256-0","volume":"247","year":"1998","journal-title":"Neurosci. Lett."},{"key":"2016021216262821000_155.1.41.24","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/S0006-291X(88)80503-5","volume":"151","year":"1988","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2016021216262821000_155.1.41.25","doi-asserted-by":"crossref","first-page":"14774","DOI":"10.1016\/S0021-9258(17)43727-6","volume":"258","year":"1983","journal-title":"J. Biol. Chem."},{"key":"2016021216262821000_155.1.41.26","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1073\/pnas.95.5.2509","volume":"95","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2016021216262821000_155.1.41.27","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1126\/science.795030","volume":"194","year":"1976","journal-title":"Science."},{"key":"2016021216262821000_155.1.41.28","doi-asserted-by":"crossref","first-page":"14147","DOI":"10.1074\/jbc.274.20.14147","volume":"274","year":"1999","journal-title":"J. Biol. Chem."},{"key":"2016021216262821000_155.1.41.29","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1242\/jcs.19.2.395","volume":"19","year":"1975","journal-title":"J. Cell Sci."},{"key":"2016021216262821000_155.1.41.30","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/71701","volume":"24","year":"2000","journal-title":"Nat. Genet."},{"key":"2016021216262821000_155.1.41.31","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1042\/bj2100297","volume":"210","year":"1983","journal-title":"Biochem. J."},{"key":"2016021216262821000_155.1.41.32","doi-asserted-by":"crossref","first-page":"3154","DOI":"10.1073\/pnas.82.10.3154","volume":"82","year":"1985","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2016021216262821000_155.1.41.33","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1126\/science.262.5139.1499-d","volume":"262","year":"1993","journal-title":"Science."},{"key":"2016021216262821000_155.1.41.34","doi-asserted-by":"crossref","first-page":"6145","DOI":"10.1073\/pnas.95.11.6145","volume":"95","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2016021216262821000_155.1.41.35","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1074\/jbc.274.4.1869","volume":"274","year":"1999","journal-title":"J. Biol. Chem."},{"key":"2016021216262821000_155.1.41.36","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/0006-291X(92)91309-E","volume":"187","year":"1992","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2016021216262821000_155.1.41.37","doi-asserted-by":"crossref","first-page":"13281","DOI":"10.1074\/jbc.274.19.13281","volume":"274","year":"1999","journal-title":"J. Biol. Chem."},{"key":"2016021216262821000_155.1.41.38","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0005-2736(82)90214-0","volume":"691","year":"1982","journal-title":"Biochim. Biophys. Acta."},{"key":"2016021216262821000_155.1.41.39","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/331315a0","volume":"331","year":"1988","journal-title":"Nature."},{"key":"2016021216262821000_155.1.41.40","doi-asserted-by":"crossref","first-page":"12583","DOI":"10.1074\/jbc.274.18.12583","volume":"274","year":"1999","journal-title":"J. Biol. Chem."},{"key":"2016021216262821000_155.1.41.41","doi-asserted-by":"crossref","first-page":"20856","DOI":"10.1016\/S0021-9258(18)54788-8","volume":"266","year":"1991","journal-title":"J. Biol. Chem."},{"key":"2016021216262821000_155.1.41.42","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/28190","volume":"394","year":"1998","journal-title":"Nature."},{"key":"2016021216262821000_155.1.41.43","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0959-4388(97)80061-X","volume":"7","year":"1997","journal-title":"Curr. Opin. Neurobiol."},{"key":"2016021216262821000_155.1.41.44","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1038\/42264","volume":"388","year":"1997","journal-title":"Nature"},{"key":"2016021216262821000_155.1.41.45","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1210\/endo-127-1-126","volume":"127","year":"1990","journal-title":"Endocrinology."},{"key":"2016021216262821000_155.1.41.46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0304-4157(95)00017-8","volume":"1286","year":"1996","journal-title":"Biochim. Biophys. Acta."},{"key":"2016021216262821000_155.1.41.47","doi-asserted-by":"crossref","first-page":"5467","DOI":"10.1002\/j.1460-2075.1995.tb00233.x","volume":"14","year":"1995","journal-title":"EMBO J."},{"key":"2016021216262821000_155.1.41.48","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1083\/jcb.139.3.601","volume":"139","year":"1997","journal-title":"J. Cell Biol."},{"key":"2016021216262821000_155.1.41.49","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0896-6273(00)80983-6","volume":"20","year":"1998","journal-title":"Neuron."},{"key":"2016021216262821000_155.1.41.50","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/27686","volume":"395","year":"1998","journal-title":"Nature."},{"key":"2016021216262821000_155.1.41.51","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0248-4900(92)90128-N","volume":"75","year":"1992","journal-title":"Biol. Cell."},{"key":"2016021216262821000_155.1.41.52","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/0092-8674(85)90124-2","volume":"42","year":"1985","journal-title":"Cell."},{"key":"2016021216262821000_155.1.41.53","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1021\/bi00409a040","volume":"27","year":"1988","journal-title":"Biochemistry."},{"key":"2016021216262821000_155.1.41.54","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1152\/physrev.1997.77.4.901","volume":"77","year":"1997","journal-title":"Physiol. Rev."},{"key":"2016021216262821000_155.1.41.55","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1091\/mbc.8.8.1501","volume":"8","year":"1997","journal-title":"Mol. Biol. Cell."},{"key":"2016021216262821000_155.1.41.56","doi-asserted-by":"crossref","first-page":"5298","DOI":"10.1093\/emboj\/17.18.5298","volume":"17","year":"1998","journal-title":"EMBO J."},{"key":"2016021216262821000_155.1.41.57","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1042\/bj3310669","volume":"331","year":"1998","journal-title":"Biochem. J."},{"key":"2016021216262821000_155.1.41.58","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1042\/bj3330193","volume":"333","year":"1998","journal-title":"Biochem. J."},{"key":"2016021216262821000_155.1.41.59","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1152\/physrev.1994.74.3.595","volume":"74","year":"1994","journal-title":"Physiol. Rev."},{"key":"2016021216262821000_155.1.41.60","doi-asserted-by":"crossref","first-page":"10118","DOI":"10.1016\/S0021-9258(18)90937-3","volume":"259","year":"1984","journal-title":"J. Biol. Chem."},{"key":"2016021216262821000_155.1.41.61","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1073\/pnas.93.7.2745","volume":"93","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2016021216262821000_155.1.41.62","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1002\/j.1460-2075.1991.tb08069.x","volume":"10","year":"1991","journal-title":"EMBO J."},{"key":"2016021216262821000_155.1.41.63","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1126\/science.8235595","volume":"262","year":"1993","journal-title":"Science."},{"key":"2016021216262821000_155.1.41.64","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/0076-6879(95)60155-4","volume":"260","year":"1995","journal-title":"Methods Enzymol."},{"key":"2016021216262821000_155.1.41.65","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s001250050706","volume":"40","year":"1997","journal-title":"Diabetologia."},{"key":"2016021216262821000_155.1.41.66","first-page":"253:935","volume":"252","year":"1988","journal-title":"Biochem. J."},{"key":"2016021216262821000_155.1.41.67","doi-asserted-by":"crossref","first-page":"22385","DOI":"10.1016\/S0021-9258(18)41540-2","volume":"268","year":"1993","journal-title":"J. Biol. Chem."},{"key":"2016021216262821000_155.1.41.68","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0143-4160(94)90002-7","volume":"16","year":"1994","journal-title":"Cell Calcium."},{"key":"2016021216262821000_155.1.41.69","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1006\/bbrc.1998.9727","volume":"253","year":"1998","journal-title":"Biochem Biophys. Res. Commun."},{"key":"2016021216262821000_155.1.41.70","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1210\/mend.11.5.9922","volume":"11","year":"1997","journal-title":"Mol. Endocrinol."},{"key":"2016021216262821000_155.1.41.71","doi-asserted-by":"crossref","first-page":"19002","DOI":"10.1074\/jbc.273.30.19002","volume":"273","year":"1998","journal-title":"J. Biol. Chem."},{"key":"2016021216262821000_155.1.41.72","first-page":"783","volume":"45","year":"1998","journal-title":"Biochem. Mol. Biol. Int."},{"key":"2016021216262821000_155.1.41.73","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0143-4160(93)90041-4","volume":"14","year":"1993","journal-title":"Cell Calcium."},{"key":"2016021216262821000_155.1.41.74","doi-asserted-by":"crossref","first-page":"9895","DOI":"10.1074\/jbc.272.15.9895","volume":"272","year":"1997","journal-title":"J. Biol. Chem."},{"key":"2016021216262821000_155.1.41.75","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/BF01868717","volume":"81","year":"1984","journal-title":"J. Membr. Biol."},{"key":"2016021216262821000_155.1.41.76","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/0896-6273(89)90193-1","volume":"2","year":"1989","journal-title":"Neuron."},{"key":"2016021216262821000_155.1.41.77","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1126\/science.8420005","volume":"259","year":"1993","journal-title":"Science."},{"key":"2016021216262821000_155.1.41.78","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/339439a0","volume":"339","year":"1989","journal-title":"Nature."},{"key":"2016021216262821000_155.1.41.79","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/BF01964706","volume":"29","year":"1990","journal-title":"Agents Actions."},{"key":"2016021216262821000_155.1.41.80","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.1073\/pnas.96.6.3206","volume":"96","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2016021216262821000_155.1.41.81","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1016\/S0028-3908(99)00223-3","volume":"39","year":"2000","journal-title":"Neuropharmacology."},{"key":"2016021216262821000_155.1.41.82","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1768-322X.1998.tb01043.x","volume":"90","year":"1998","journal-title":"Biol. Cell."},{"key":"2016021216262821000_155.1.41.83","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/S0960-9822(00)00756-9","volume":"10","year":"2000","journal-title":"Curr. Biol."},{"key":"2016021216262821000_155.1.41.84","unstructured":"Varadi, A., and G.A. Rutter. 2001. Dynamic imaging of endoplasmic reticulum [Ca2+] in MIN6 cells using recombinant cameleons: roles of SERCA2 and ryanodine receptors. Diabetes. In press."},{"key":"2016021216262821000_155.1.41.85","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/S0166-2236(00)01621-0","volume":"23","year":"2000","journal-title":"Trends Neurosci."},{"key":"2016021216262821000_155.1.41.86","doi-asserted-by":"crossref","first-page":"13446","DOI":"10.1016\/S0021-9258(18)77367-5","volume":"265","year":"1990","journal-title":"J. Biol. Chem."},{"key":"2016021216262821000_155.1.41.87","doi-asserted-by":"crossref","first-page":"9093","DOI":"10.1074\/jbc.272.14.9093","volume":"272","year":"1997","journal-title":"J. Biol. Chem."},{"key":"2016021216262821000_155.1.41.88","first-page":"1192","volume":"44","year":"1993","journal-title":"Mol. Pharmacol."}],"container-title":["The Journal of Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1083\/jcb.200103145","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T04:41:32Z","timestamp":1621226492000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jcb.org\/lookup\/doi\/10.1083\/jcb.200103145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,9,24]]},"references-count":88,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2001,10,1]]},"published-print":{"date-parts":[[2001,10,1]]}},"alternative-id":["10.1083\/jcb.200103145"],"URL":"https:\/\/doi.org\/10.1083\/jcb.200103145","relation":{},"ISSN":["0021-9525","1540-8140"],"issn-type":[{"value":"0021-9525","type":"print"},{"value":"1540-8140","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,9,24]]}}}