{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:15:51Z","timestamp":1792800951354,"version":"4.5.0"},"reference-count":53,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,8,5]]},"abstract":"<jats:p>Listeria monocytogenes has emerged as a remarkably tractable pathogen to dissect basic aspects of cell biology, intracellular pathogenesis, and innate and acquired immunity. In order to maintain its intracellular lifestyle, L. monocytogenes has evolved a number of mechanisms to exploit host processes to grow and spread cell to cell without damaging the host cell. The pore-forming protein listeriolysin O mediates escape from host vacuoles and utilizes multiple fail-safe mechanisms to avoid causing toxicity to infected cells. Once in the cytosol, the L. monocytogenes ActA protein recruits host cell Arp2\/3 complexes and enabled\/vasodilator-stimulated phosphoprotein family members to mediate efficient actin-based motility, thereby propelling the bacteria into neighboring cells. Alteration in any of these processes dramatically reduces the ability of the bacteria to establish a productive infection in vivo.<\/jats:p>","DOI":"10.1083\/jcb.200205009","type":"journal-article","created":{"date-parts":[[2002,9,18]],"date-time":"2002-09-18T14:04:15Z","timestamp":1032357855000},"page":"409-414","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":368,"title":["The cell biology of\n                    <i>Listeria monocytogenes<\/i>\n                    infection"],"prefix":"10.1083","volume":"158","author":[{"given":"Daniel A.","family":"Portnoy","sequence":"first","affiliation":[{"name":"1Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720"},{"name":"2The School of Public Health, University of California, Berkeley, CA 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Auerbuch","sequence":"additional","affiliation":[{"name":"1Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian J.","family":"Glomski","sequence":"additional","affiliation":[{"name":"1Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2002,8,5]]},"reference":[{"key":"2023072904422953800_BIB1","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1242\/jcs.110.6.731","volume":"110","year":"1997","journal-title":"J. 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