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Although the BMPR-II tail is not involved in BMP signaling via Smad proteins, mutations truncating this domain are present in patients with primary pulmonary hypertension (PPH). Further analysis revealed that the interaction between LIMK1 and BMPR-II inhibited LIMK1's ability to phosphorylate cofilin, which could then be alleviated by addition of BMP4. A BMPR-II mutant containing the smallest COOH-terminal truncation described in PPH failed to bind or inhibit LIMK1. This study identifies the first function of the BMPR-II tail domain and suggests that the deregulation of actin dynamics may contribute to the etiology of PPH.<\/jats:p>","DOI":"10.1083\/jcb.200212060","type":"journal-article","created":{"date-parts":[[2003,9,9]],"date-time":"2003-09-09T02:40:05Z","timestamp":1063075205000},"page":"1089-1098","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":294,"title":["Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1"],"prefix":"10.1083","volume":"162","author":[{"given":"Victoria C.","family":"Foletta","sequence":"first","affiliation":[{"name":"1The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade Parkville, Victoria 3050, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei Ann","family":"Lim","sequence":"additional","affiliation":[{"name":"1The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade Parkville, Victoria 3050, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Soosairajah","sequence":"additional","affiliation":[{"name":"1The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade Parkville, Victoria 3050, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"April P.","family":"Kelly","sequence":"additional","affiliation":[{"name":"1The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade Parkville, Victoria 3050, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edouard G.","family":"Stanley","sequence":"additional","affiliation":[{"name":"1The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade Parkville, Victoria 3050, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Shannon","sequence":"additional","affiliation":[{"name":"1The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade Parkville, Victoria 3050, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"He","sequence":"additional","affiliation":[{"name":"2Cell Biology Program and Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10021"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supratik","family":"Das","sequence":"additional","affiliation":[{"name":"2Cell Biology Program and Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10021"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Massague\u0301","sequence":"additional","affiliation":[{"name":"2Cell Biology Program and Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10021"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ora","family":"Bernard","sequence":"additional","affiliation":[{"name":"1The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade Parkville, Victoria 3050, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2003,9,8]]},"reference":[{"key":"2023072214291344100_BIB1","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0896-6273(02)00589-5","volume":"33","year":"2002","journal-title":"Neuron."},{"key":"2023072214291344100_BIB2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0092-8674(03)00204-6","volume":"113","year":"2003","journal-title":"Cell."},{"key":"2023072214291344100_BIB3","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/31729","volume":"393","year":"1998","journal-title":"Nature."},{"key":"2023072214291344100_BIB4","first-page":"1159","volume":"5","year":"1994","journal-title":"Cell Growth Differ."},{"key":"2023072214291344100_BIB5","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1042\/bj20021152","volume":"369","year":"2003","journal-title":"Biochem. 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