{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T07:14:54Z","timestamp":1791011694074,"version":"4.1.0"},"reference-count":69,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2003,11,24]]},"abstract":"<jats:p>The SDF-1\u03b1\/CXCR4 ligand\/chemokine receptor pair is required for appropriate patterning during ontogeny and stimulates the growth and differentiation of critical cell types. Here, we demonstrate SDF-1\u03b1 and CXCR4 expression in fetal pancreas. We have found that SDF-1\u03b1 and its receptor CXCR4 are expressed in islets, also CXCR4 is expressed in and around the proliferating duct epithelium of the regenerating pancreas of the interferon (IFN) \u03b3\u2013nonobese diabetic mouse. We show that SDF-1\u03b1 stimulates the phosphorylation of Akt, mitogen-activated protein kinase, and Src in pancreatic duct cells. Furthermore, migration assays indicate a stimulatory effect of SDF-1\u03b1 on ductal cell migration. Importantly, blocking the SDF-1\u03b1\/CXCR4 axis in IFN\u03b3-nonobese diabetic mice resulted in diminished proliferation and increased apoptosis in the pancreatic ductal cells. Together, these data indicate that the SDF-1\u03b1\u2013CXCR4 ligand receptor axis is an obligatory component in the maintenance of duct cell survival, proliferation, and migration during pancreatic regeneration.<\/jats:p>","DOI":"10.1083\/jcb.200304153","type":"journal-article","created":{"date-parts":[[2003,11,24]],"date-time":"2003-11-24T22:12:18Z","timestamp":1069711938000},"page":"859-869","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":91,"title":["The stromal cell\u2013derived factor-1\u03b1\/CXCR4 ligand\u2013receptor axis is critical for progenitor survival and migration in the pancreas"],"prefix":"10.1083","volume":"163","author":[{"given":"Ayse G.","family":"Kayali","sequence":"first","affiliation":[{"name":"1Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Van Gunst","sequence":"additional","affiliation":[{"name":"1Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain L.","family":"Campbell","sequence":"additional","affiliation":[{"name":"2Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandr","family":"Stotland","sequence":"additional","affiliation":[{"name":"1Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcie","family":"Kritzik","sequence":"additional","affiliation":[{"name":"1Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoxun","family":"Liu","sequence":"additional","affiliation":[{"name":"1Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malin","family":"Flodstro\u0308m-Tullberg","sequence":"additional","affiliation":[{"name":"1Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You-Qing","family":"Zhang","sequence":"additional","affiliation":[{"name":"1Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Sarvetnick","sequence":"additional","affiliation":[{"name":"1Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2003,11,24]]},"reference":[{"key":"2023072214515824100_BIB1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1084\/jem.185.1.111","volume":"185","year":"1997","journal-title":"J. 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