{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:20:22Z","timestamp":1791181222258,"version":"4.1.0"},"reference-count":27,"publisher":"Rockefeller University Press","issue":"2","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2003,10,27]]},"abstract":"<jats:p>Disruption of the BPAG1 (bullous pemphigoid antigen 1) gene results in progressive deterioration in motor function and devastating sensory neurodegeneration in the null mice. We have previously demonstrated that BPAG1n1 and BPAG1n3 play important roles in organizing cytoskeletal networks in vivo. Here, we characterize functions of a novel BPAG1 neuronal isoform, BPAG1n4. Results obtained from yeast two-hybrid screening, blot overlay binding assays, and coimmunoprecipitations demonstrate that BPAG1n4 interacts directly with dynactin p150Glued through its unique ezrin\/radixin\/moesin domain. Studies using double immunofluorescent microscopy and ultrastructural analysis reveal physiological colocalization of BPAG1n4 with dynactin\/dynein. Disruption of the interaction between BPAG1n4 and dynactin results in severe defects in retrograde axonal transport. We conclude that BPAG1n4 plays an essential role in retrograde axonal transport in sensory neurons. These findings might advance our understanding of pathogenesis of axonal degeneration and neuronal death.<\/jats:p>","DOI":"10.1083\/jcb.200306075","type":"journal-article","created":{"date-parts":[[2003,10,28]],"date-time":"2003-10-28T07:13:57Z","timestamp":1067325237000},"page":"223-229","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":70,"title":["BPAG1n4 is essential for retrograde axonal transport in sensory neurons"],"prefix":"10.1083","volume":"163","author":[{"given":"Jia-Jia","family":"Liu","sequence":"first","affiliation":[{"name":"1Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqing","family":"Ding","sequence":"additional","affiliation":[{"name":"1Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony S.","family":"Kowal","sequence":"additional","affiliation":[{"name":"1Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Nardine","sequence":"additional","affiliation":[{"name":"1Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Allen","sequence":"additional","affiliation":[{"name":"1Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Dominique","family":"Delcroix","sequence":"additional","affiliation":[{"name":"1Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengbiao","family":"Wu","sequence":"additional","affiliation":[{"name":"1Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Mobley","sequence":"additional","affiliation":[{"name":"1Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Fuchs","sequence":"additional","affiliation":[{"name":"2Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10021"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmin","family":"Yang","sequence":"additional","affiliation":[{"name":"1Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2003,10,27]]},"reference":[{"key":"2023072905095012700_BIB1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/318295a0","volume":"318","year":"1985","journal-title":"Nature."},{"key":"2023072905095012700_BIB2","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/81701","volume":"26","year":"2000","journal-title":"Nat. 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