{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:57:47Z","timestamp":1791251867437,"version":"4.1.0"},"reference-count":44,"publisher":"Rockefeller University Press","issue":"1","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2004,4,12]]},"abstract":"<jats:p>A new mouse line has been produced in which the sixth Ig domain of the L1 cell adhesion molecule has been deleted. Despite the rather large deletion, L1 expression is preserved at normal levels. In vitro experiments showed that L1\u2013L1 homophilic binding was lost, along with L1-\u03b15\u03b21 integrin binding. However, L1\u2013neurocan and L1\u2013neuropilin binding were preserved and sema3a responses were intact. Surprisingly, many of the axon guidance defects present in the L1 knockout mice, such as abnormal corticospinal tract and corpus callosum, were not observed. Nonetheless, when backcrossed on the C57BL\/6 strain, a severe hydrocephalus was observed and after several generations, became an embryonic lethal. These results imply that L1 binding to L1, TAG-1, or F3, and L1-\u03b15\u03b21 integrin binding are not essential for normal development of a variety of axon pathways, and suggest that L1\u2013L1 homophilic binding is important in the production of X-linked hydrocephalus.<\/jats:p>","DOI":"10.1083\/jcb.200312107","type":"journal-article","created":{"date-parts":[[2004,4,5]],"date-time":"2004-04-05T20:54:11Z","timestamp":1081198451000},"page":"145-154","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":82,"title":["Brain development in mice lacking L1\u2013L1 homophilic adhesion"],"prefix":"10.1083","volume":"165","author":[{"given":"Kyoko","family":"Itoh","sequence":"first","affiliation":[{"name":"1Department of Neuroscience, Case Western Reserve University, Cleveland, OH 44106"},{"name":"2Department of Pathology and Applied Neurobiology, Kyoto Prefectural University of Medicine, Kyoto 602-0841, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Cheng","sequence":"additional","affiliation":[{"name":"1Department of Neuroscience, Case Western Reserve University, Cleveland, OH 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimasa","family":"Kamei","sequence":"additional","affiliation":[{"name":"1Department of Neuroscience, Case Western Reserve University, Cleveland, OH 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Fushiki","sequence":"additional","affiliation":[{"name":"2Department of Pathology and Applied Neurobiology, Kyoto Prefectural University of Medicine, Kyoto 602-0841, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Kamiguchi","sequence":"additional","affiliation":[{"name":"3Developmental Brain Science Group, RIKEN Brain Science Institute, Saitama 351-0198, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Gutwein","sequence":"additional","affiliation":[{"name":"4D010, German Cancer Research Center, D-69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Stoeck","sequence":"additional","affiliation":[{"name":"4D010, German Cancer Research Center, D-69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Arnold","sequence":"additional","affiliation":[{"name":"5D050 Tumor Immunology Program, German Cancer Research Center, D-69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Altevogt","sequence":"additional","affiliation":[{"name":"4D010, German Cancer Research Center, D-69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vance","family":"Lemmon","sequence":"additional","affiliation":[{"name":"1Department of Neuroscience, Case Western Reserve University, Cleveland, OH 44106"},{"name":"6The Miami Project to Cure Paralysis, University of Miami School of Medicine, Miami, FL 33136"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2004,4,5]]},"reference":[{"key":"2023072905204915100_BIB1","doi-asserted-by":"crossref","first-page":"13264","DOI":"10.1074\/jbc.274.19.13264","volume":"274","year":"1999","journal-title":"J. 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