{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:59:48Z","timestamp":1791266388042,"version":"4.1.0"},"reference-count":24,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2004,2,16]]},"abstract":"<jats:p>Amylin is a member of the calcitonin family of hormones cosecreted with insulin by pancreatic \u03b2 cells. Cell culture assays suggest that amylin could affect bone formation and bone resorption, this latter function after its binding to the calcitonin receptor (CALCR). Here we show that Amylin inactivation leads to a low bone mass due to an increase in bone resorption, whereas bone formation is unaffected. In vitro, amylin inhibits fusion of mononucleated osteoclast precursors into multinucleated osteoclasts in an ERK1\/2-dependent manner. Although Amylin +\/\u2212 mice like Amylin-deficient mice display a low bone mass phenotype and increased bone resorption, Calcr +\/\u2212 mice display a high bone mass due to an increase in bone formation. Moreover, compound heterozygote mice for Calcr and Amylin inactivation displayed bone abnormalities observed in both Calcr +\/\u2212 and Amylin +\/\u2212 mice, thereby ruling out that amylin uses CALCR to inhibit osteoclastogenesis in vivo. Thus, amylin is a physiological regulator of bone resorption that acts through an unidentified receptor.<\/jats:p>","DOI":"10.1083\/jcb.200312135","type":"journal-article","created":{"date-parts":[[2004,2,17]],"date-time":"2004-02-17T20:36:29Z","timestamp":1077050189000},"page":"509-514","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":177,"title":["Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo"],"prefix":"10.1083","volume":"164","author":[{"given":"Romain","family":"Dacquin","sequence":"first","affiliation":[{"name":"1Department of Molecular and Human Genetics and Bone Disease Program of Texas, Baylor College of Medicine, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel A.","family":"Davey","sequence":"additional","affiliation":[{"name":"2Department of Medicine, Austin Health, University of Melbourne, Victoria 3084 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Laplace","sequence":"additional","affiliation":[{"name":"3Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Re\u0301gis","family":"Levasseur","sequence":"additional","affiliation":[{"name":"1Department of Molecular and Human Genetics and Bone Disease Program of Texas, Baylor College of Medicine, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard A.","family":"Morris","sequence":"additional","affiliation":[{"name":"4Hanson Institute, Adelaide, South Australia 5000 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Goldring","sequence":"additional","affiliation":[{"name":"3Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Gebre-Medhin","sequence":"additional","affiliation":[{"name":"5Department of Clinical Genetics, Lund University Hospital, SE-221 85, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah L.","family":"Galson","sequence":"additional","affiliation":[{"name":"3Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115"},{"name":"6Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D.","family":"Zajac","sequence":"additional","affiliation":[{"name":"2Department of Medicine, Austin Health, University of Melbourne, Victoria 3084 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge\u0301rard","family":"Karsenty","sequence":"additional","affiliation":[{"name":"1Department of Molecular and Human Genetics and Bone Disease Program of Texas, Baylor College of Medicine, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2004,2,17]]},"reference":[{"key":"2023072905203979100_BIB1","doi-asserted-by":"crossref","first-page":"22663","DOI":"10.1074\/jbc.M007104200","volume":"276","year":"2001","journal-title":"J. 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