{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T22:12:16Z","timestamp":1789942336676,"version":"4.0.1"},"reference-count":43,"publisher":"Rockefeller University Press","issue":"5","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2004,8,30]]},"abstract":"<jats:p>The myelin and lymphocyte protein (MAL) is a tetraspan raft-associated proteolipid predominantly expressed by oligodendrocytes and Schwann cells. We show that genetic ablation of mal resulted in cytoplasmic inclusions within compact myelin, paranodal loops that are everted away from the axon, and disorganized transverse bands at the paranode\u2013axon interface in the adult central nervous system. These structural changes were accompanied by a marked reduction of contactin-associated protein\/paranodin, neurofascin 155 (NF155), and the potassium channel Kv1.2, whereas nodal clusters of sodium channels were unaltered. Initial formation of paranodal regions appeared normal, but abnormalities became detectable when MAL started to be expressed. Biochemical analysis revealed reduced myelin-associated glycoprotein, myelin basic protein, and NF155 protein levels in myelin and myelin-derived rafts. Our results demonstrate a critical role for MAL in the maintenance of central nervous system paranodes, likely by controlling the trafficking and\/or sorting of NF155 and other membrane components in oligodendrocytes.<\/jats:p>","DOI":"10.1083\/jcb.200406092","type":"journal-article","created":{"date-parts":[[2004,8,30]],"date-time":"2004-08-30T18:33:10Z","timestamp":1093890790000},"page":"731-742","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":116,"title":["The raft-associated protein MAL is required for maintenance of proper axon\u2013glia interactions in the central nervous system"],"prefix":"10.1083","volume":"166","author":[{"given":"Nicole","family":"Schaeren-Wiemers","sequence":"first","affiliation":[{"name":"1Neurobiology, Department of Research, University Hospital Basel, 4056 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annick","family":"Bonnet","sequence":"additional","affiliation":[{"name":"2Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH-Ho\u0308nggerberg, 8093 Zu\u0308rich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Erb","sequence":"additional","affiliation":[{"name":"1Neurobiology, Department of Research, University Hospital Basel, 4056 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beat","family":"Erne","sequence":"additional","affiliation":[{"name":"1Neurobiology, Department of Research, University Hospital Basel, 4056 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udo","family":"Bartsch","sequence":"additional","affiliation":[{"name":"3Center for Molecular Neurobiology Hamburg (ZMNH) and Department of Ophthalmology, University of Hamburg, 20146 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances","family":"Kern","sequence":"additional","affiliation":[{"name":"1Neurobiology, Department of Research, University Hospital Basel, 4056 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ned","family":"Mantei","sequence":"additional","affiliation":[{"name":"2Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH-Ho\u0308nggerberg, 8093 Zu\u0308rich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Sherman","sequence":"additional","affiliation":[{"name":"4Center for Neuroscience Research, University of Edinburgh, Edinburgh EH9 1QH, Scotland, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ueli","family":"Suter","sequence":"additional","affiliation":[{"name":"2Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH-Ho\u0308nggerberg, 8093 Zu\u0308rich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2004,8,30]]},"reference":[{"key":"2023072215133385100_BIB1","first-page":"151","volume":"8","year":"1990","journal-title":"Clin. 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