{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T07:49:22Z","timestamp":1791100162553,"version":"4.1.0"},"reference-count":30,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2006,5,22]]},"abstract":"<jats:p>Neisseria meningitidis elicits the formation of membrane protrusions on vascular endothelial cells, enabling its internalization and transcytosis. We provide evidence that this process interferes with the transendothelial migration of leukocytes. Bacteria adhering to endothelial cells actively recruit ezrin, moesin, and ezrin binding adhesion molecules. These molecules no longer accumulate at sites of leukocyte\u2013endothelial contact, preventing the formation of the endothelial docking structures required for proper leukocyte diapedesis. Overexpression of exogenous ezrin or moesin is sufficient to rescue the formation of docking structures on and leukocyte migration through infected endothelial monolayers. Inversely, expression of the dominant-negative NH2-terminal domain of ezrin markedly inhibits the formation of docking structures and leukocyte diapedesis through noninfected monolayers. Ezrin and moesin thus appear as pivotal endothelial proteins required for leukocyte diapedesis that are titrated away by N. meningitidis. These results highlight a novel strategy developed by a bacterial pathogen to hamper the host inflammatory response by interfering with leukocyte\u2013endothelial cell interaction.<\/jats:p>","DOI":"10.1083\/jcb.200507128","type":"journal-article","created":{"date-parts":[[2006,5,22]],"date-time":"2006-05-22T18:42:05Z","timestamp":1148323325000},"page":"627-637","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":81,"title":["<i>Neisseria meningitidis<\/i> infection of human endothelial cells interferes with leukocyte transmigration by preventing the formation of endothelial docking structures"],"prefix":"10.1083","volume":"173","author":[{"given":"Nicolas","family":"Doulet","sequence":"first","affiliation":[{"name":"1De\u0301partement de Biologie Cellulaire, Institut Cochin, F-75014 Paris, France"},{"name":"2Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, U567, F-75014 Paris, France"},{"name":"3Centre National de la Recherche Scientifique, UMR 8104, F-75014 Paris, France"},{"name":"4Universite\u0301 Paris Descartes, Faculte\u0301 de Me\u0301decine Rene\u0301 Descartes, UMR-S 8104, F-75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Donnadieu","sequence":"additional","affiliation":[{"name":"1De\u0301partement de Biologie Cellulaire, Institut Cochin, F-75014 Paris, France"},{"name":"2Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, U567, F-75014 Paris, France"},{"name":"3Centre National de la Recherche Scientifique, UMR 8104, F-75014 Paris, France"},{"name":"4Universite\u0301 Paris Descartes, Faculte\u0301 de Me\u0301decine Rene\u0301 Descartes, UMR-S 8104, F-75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Pierre","family":"Laran-Chich","sequence":"additional","affiliation":[{"name":"1De\u0301partement de Biologie Cellulaire, Institut Cochin, F-75014 Paris, France"},{"name":"2Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, U567, F-75014 Paris, France"},{"name":"3Centre National de la Recherche Scientifique, UMR 8104, F-75014 Paris, France"},{"name":"4Universite\u0301 Paris Descartes, Faculte\u0301 de Me\u0301decine Rene\u0301 Descartes, UMR-S 8104, F-75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Niedergang","sequence":"additional","affiliation":[{"name":"1De\u0301partement de Biologie Cellulaire, Institut Cochin, F-75014 Paris, France"},{"name":"2Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, U567, F-75014 Paris, France"},{"name":"3Centre National de la Recherche Scientifique, UMR 8104, F-75014 Paris, France"},{"name":"4Universite\u0301 Paris Descartes, Faculte\u0301 de Me\u0301decine Rene\u0301 Descartes, UMR-S 8104, F-75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Nassif","sequence":"additional","affiliation":[{"name":"5Laboratoire de Microbiologie, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale U570, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre Olivier","family":"Couraud","sequence":"additional","affiliation":[{"name":"1De\u0301partement de Biologie Cellulaire, Institut Cochin, F-75014 Paris, France"},{"name":"2Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, U567, F-75014 Paris, France"},{"name":"3Centre National de la Recherche Scientifique, UMR 8104, F-75014 Paris, France"},{"name":"4Universite\u0301 Paris Descartes, Faculte\u0301 de Me\u0301decine Rene\u0301 Descartes, UMR-S 8104, F-75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Bourdoulous","sequence":"additional","affiliation":[{"name":"1De\u0301partement de Biologie Cellulaire, Institut Cochin, F-75014 Paris, France"},{"name":"2Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, U567, F-75014 Paris, France"},{"name":"3Centre National de la Recherche Scientifique, UMR 8104, F-75014 Paris, France"},{"name":"4Universite\u0301 Paris Descartes, Faculte\u0301 de Me\u0301decine Rene\u0301 Descartes, UMR-S 8104, F-75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2006,5,22]]},"reference":[{"key":"2023072910190314400_BIB1","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1083\/jcb.200112126","volume":"157","year":"2002","journal-title":"J. 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