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In addition, NCS-1 proteins increased upon treatment with glial cell line\u2013derived neurotrophic factor (GDNF) and mediated GDNF survival signal in an Akt (but not MAPK)-dependent manner. Furthermore, NCS-1 is significantly up-regulated in response to axotomy-induced injury in the dorsal motor nucleus of the vagus neurons of adult rats in vivo, and adenoviral overexpression of E120Q resulted in a significant loss of surviving neurons, suggesting that NCS-1 is involved in an antiapoptotic mechanism in adult motor neurons. We propose that NCS-1 is a novel survival-promoting factor up-regulated in injured neurons that mediates the GDNF survival signal via the phosphatidylinositol 3-kinase\u2013Akt pathway.<\/jats:p>","DOI":"10.1083\/jcb.200508156","type":"journal-article","created":{"date-parts":[[2006,3,20]],"date-time":"2006-03-20T20:33:50Z","timestamp":1142886830000},"page":"1081-1091","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":60,"title":["Novel role of neuronal Ca2+ sensor-1 as a survival factor up-regulated in injured neurons"],"prefix":"10.1083","volume":"172","author":[{"given":"Tomoe Y.","family":"Nakamura","sequence":"first","affiliation":[{"name":"1Department of Molecular Physiology, National Cardiovascular Center Research Institute, Suita, Osaka 565-8565, Japan"},{"name":"2Department of Cellular and System Physiology, Graduate School of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Jeromin","sequence":"additional","affiliation":[{"name":"4Neuroscience, Baylor College of Medicine, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Smith","sequence":"additional","affiliation":[{"name":"5Department of Physiology, University of Kentucky Medical School, Lexington, KY 50536"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Kurushima","sequence":"additional","affiliation":[{"name":"3Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Koga","sequence":"additional","affiliation":[{"name":"2Department of Cellular and System Physiology, Graduate School of Medical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusaku","family":"Nakabeppu","sequence":"additional","affiliation":[{"name":"3Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeo","family":"Wakabayashi","sequence":"additional","affiliation":[{"name":"1Department of Molecular Physiology, National Cardiovascular Center Research Institute, Suita, Osaka 565-8565, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Nabekura","sequence":"additional","affiliation":[{"name":"2Department of Cellular and System Physiology, Graduate School of Medical Sciences"},{"name":"6Division of Homeostatic Development, National Institute of Physiological Sciences, Okazaki 444-8585, Japan"},{"name":"7Core Research for Evolutional Science and Technology, the Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2006,3,20]]},"reference":[{"key":"2023072907071899200_BIB1","doi-asserted-by":"crossref","first-page":"6541","DOI":"10.1002\/j.1460-2075.1996.tb01045.x","volume":"15","year":"1996","journal-title":"EMBO J."},{"key":"2023072907071899200_BIB2","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/nrn1477","volume":"5","year":"2004","journal-title":"Nat. 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