{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:50:07Z","timestamp":1791298207529,"version":"4.1.0"},"reference-count":61,"publisher":"Rockefeller University Press","issue":"5","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2007,2,26]]},"abstract":"<jats:p>RAD51C is a member of the RecA\/RAD51 protein family, which is known to play an important role in DNA repair by homologous recombination. In mice, it is essential for viability. Therefore, we have generated a hypomorphic allele of Rad51c in addition to a null allele. A subset of mice expressing the hypomorphic allele is infertile. This infertility is caused by sexually dimorphic defects in meiotic recombination, revealing its two distinct functions. Spermatocytes undergo a developmental arrest during the early stages of meiotic prophase I, providing evidence for the role of RAD51C in early stages of RAD51-mediated recombination. In contrast, oocytes can progress normally to metaphase I after superovulation but display precocious separation of sister chromatids, aneuploidy, and broken chromosomes at metaphase II. These defects suggest a possible late role of RAD51C in meiotic recombination. Based on the marked reduction in Holliday junction (HJ) resolution activity in Rad51c-null mouse embryonic fibroblasts, we propose that this late function may be associated with HJ resolution.<\/jats:p>","DOI":"10.1083\/jcb.200608130","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T04:24:39Z","timestamp":1172031879000},"page":"581-592","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":115,"title":["RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females"],"prefix":"10.1083","volume":"176","author":[{"given":"Sergey","family":"Kuznetsov","sequence":"first","affiliation":[{"name":"1Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Pellegrini","sequence":"additional","affiliation":[{"name":"2Experimental Immunology Branch, National Cancer Institute, Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristy","family":"Shuda","sequence":"additional","affiliation":[{"name":"3Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Fernandez-Capetillo","sequence":"additional","affiliation":[{"name":"2Experimental Immunology Branch, National Cancer Institute, Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilun","family":"Liu","sequence":"additional","affiliation":[{"name":"4Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, England, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty K.","family":"Martin","sequence":"additional","affiliation":[{"name":"1Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Burkett","sequence":"additional","affiliation":[{"name":"1Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen","family":"Southon","sequence":"additional","affiliation":[{"name":"1Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debananda","family":"Pati","sequence":"additional","affiliation":[{"name":"5Department of Pediatrics, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lino","family":"Tessarollo","sequence":"additional","affiliation":[{"name":"1Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen C.","family":"West","sequence":"additional","affiliation":[{"name":"4Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, England, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Donovan","sequence":"additional","affiliation":[{"name":"6Institute for Cell Engineering, Johns Hopkins University, Baltimore, MD 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Nussenzweig","sequence":"additional","affiliation":[{"name":"2Experimental Immunology Branch, National Cancer Institute, Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyam K.","family":"Sharan","sequence":"additional","affiliation":[{"name":"1Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2007,2,20]]},"reference":[{"key":"2023072908415082900_BIB1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1093\/genetics\/165.1.197","volume":"165","year":"2003","journal-title":"Genetics."},{"key":"2023072908415082900_BIB2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/BF00352222","volume":"104","year":"1995","journal-title":"Chromosoma."},{"key":"2023072908415082900_BIB3","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/ng0796-336","volume":"13","year":"1996","journal-title":"Nat. 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