{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T12:56:29Z","timestamp":1789908989885,"version":"4.0.1"},"reference-count":27,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2007,1,29]]},"abstract":"<jats:p>Members of the Rab guanosine triphosphatase (GTPase) family are key regulators of membrane traffic. Here we examined the association of 48 Rabs with model phagosomes containing a non-invasive mutant of Salmonella enterica serovar Typhimurium (S. Typhimurium). This mutant traffics to lysosomes and allowed us to determine which Rabs localize to a maturing phagosome. In total, 18 Rabs associated with maturing phagosomes, each with its own kinetics of association. Dominant-negative mutants of Rab23 and 35 inhibited phagosome\u2013lysosome fusion. A large number of Rab GTPases localized to wild-type Salmonella-containing vacuoles (SCVs), which do not fuse with lysosomes. However, some Rabs (8B, 13, 23, 32, and 35) were excluded from wild-type SCVs whereas others (5A, 5B, 5C, 7A, 11A, and 11B) were enriched on this compartment. Our studies demonstrate that a complex network of Rab GTPases controls endocytic progression to lysosomes and that this is modulated by S. Typhimurium to allow its intracellular growth.<\/jats:p>","DOI":"10.1083\/jcb.200611056","type":"journal-article","created":{"date-parts":[[2007,2,2]],"date-time":"2007-02-02T17:15:16Z","timestamp":1170436516000},"page":"263-268","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":149,"title":["A network of Rab GTPases controls phagosome maturation and is modulated by <i>Salmonella enterica<\/i> serovar Typhimurium"],"prefix":"10.1083","volume":"176","author":[{"given":"Adam C.","family":"Smith","sequence":"first","affiliation":[{"name":"1Program in Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada, M5G 1X8"},{"name":"2Department of Medical Genetics and Microbiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Do","family":"Heo","sequence":"additional","affiliation":[{"name":"4Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Braun","sequence":"additional","affiliation":[{"name":"1Program in Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada, M5G 1X8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuju","family":"Jiang","sequence":"additional","affiliation":[{"name":"1Program in Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada, M5G 1X8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chloe","family":"Macrae","sequence":"additional","affiliation":[{"name":"3Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada, M5S 1A8"},{"name":"5Ontario Cancer Institute, Toronto, Ontario, Canada, M5G 2M9"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Casanova","sequence":"additional","affiliation":[{"name":"6Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marci A.","family":"Scidmore","sequence":"additional","affiliation":[{"name":"7Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Grinstein","sequence":"additional","affiliation":[{"name":"1Program in Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada, M5G 1X8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Meyer","sequence":"additional","affiliation":[{"name":"4Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.","family":"Brumell","sequence":"additional","affiliation":[{"name":"1Program in Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada, M5G 1X8"},{"name":"2Department of Medical Genetics and Microbiology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2007,1,29]]},"reference":[{"key":"2023072908411338300_BIB1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.cell.2005.10.031","volume":"124","year":"2006","journal-title":"Cell."},{"key":"2023072908411338300_BIB2","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1128\/IAI.73.2.1204-1208.2005","volume":"73","year":"2005","journal-title":"Infect. 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