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Rejoining of H2O2-induced DNA double-strand breaks (DSBs) was significantly reduced in AOA2 cells compared to controls, and there was no evidence for a defect in DNA single-strand break repair. This defect in DSB repair was corrected by full-length SETX cDNA. These results provide evidence that an additional member of the autosomal recessive AOA is also characterized by a defective response to DNA damage, which may contribute to the neurodegeneration seen in this syndrome.<\/jats:p>","DOI":"10.1083\/jcb.200701042","type":"journal-article","created":{"date-parts":[[2007,6,12]],"date-time":"2007-06-12T02:32:43Z","timestamp":1181615563000},"page":"969-979","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":182,"title":["Senataxin, defective in ataxia oculomotor apraxia type 2, is involved in the defense against oxidative DNA damage"],"prefix":"10.1083","volume":"177","author":[{"given":"Amila","family":"Suraweera","sequence":"first","affiliation":[{"name":"1Radiation Biology and Oncology Laboratory, Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia"},{"name":"2Central Clinical Division, University of Queensland, Brisbane, QLD 4029, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier J.","family":"Becherel","sequence":"additional","affiliation":[{"name":"1Radiation Biology and Oncology Laboratory, Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Chen","sequence":"additional","affiliation":[{"name":"1Radiation Biology and Oncology Laboratory, Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Rundle","sequence":"additional","affiliation":[{"name":"1Radiation Biology and Oncology Laboratory, Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick","family":"Woods","sequence":"additional","affiliation":[{"name":"1Radiation Biology and Oncology Laboratory, Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Nakamura","sequence":"additional","affiliation":[{"name":"3Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magtouf","family":"Gatei","sequence":"additional","affiliation":[{"name":"1Radiation Biology and Oncology Laboratory, Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Criscuolo","sequence":"additional","affiliation":[{"name":"4Department of Neurobiology, University of Naples, Naples, 80131, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Filla","sequence":"additional","affiliation":[{"name":"4Department of Neurobiology, University of Naples, Naples, 80131, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Chessa","sequence":"additional","affiliation":[{"name":"5Department of Experimental Medicine and Pathology, University \u201cLa Sapienza,\u201d Roma, 324-00161, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Fu\u00dfer","sequence":"additional","affiliation":[{"name":"6Institute of Pharmacy, University of Mainz, Mainz, 55099, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Epe","sequence":"additional","affiliation":[{"name":"6Institute of Pharmacy, University of Mainz, Mainz, 55099, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuri","family":"Gueven","sequence":"additional","affiliation":[{"name":"1Radiation Biology and Oncology Laboratory, Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin F.","family":"Lavin","sequence":"additional","affiliation":[{"name":"1Radiation Biology and Oncology Laboratory, Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia"},{"name":"2Central Clinical Division, University of Queensland, Brisbane, QLD 4029, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2007,6,11]]},"reference":[{"key":"2023072911260387700_BIB1","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/nature05164","volume":"443","year":"2006","journal-title":"Nature."},{"key":"2023072911260387700_BIB2","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/ana.410240404","volume":"24","year":"1988","journal-title":"Ann. 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