{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:39:58Z","timestamp":1790786398800,"version":"4.1.0"},"reference-count":38,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2007,11,5]]},"abstract":"<jats:p>Atrial cardiomyocytes, neurons, and endocrine tissues secrete neurotransmitters and peptide hormones via large dense-core vesicles (LDCVs). We describe a new member of the Ras family of G-proteins, named RRP17, which is expressed specifically in cardiomyocytes, neurons, and the pancreas. RRP17 interacts with Ca2+-activated protein for secretion-1 (CAPS1), one of only a few proteins known to be associated exclusively with LDCV exocytosis. Ectopic expression of RRP17 in cardiomyocytes enhances secretion of atrial natriuretic peptide (ANP), a regulator of blood pressure and natriuresis. Conversely, genetic deletion of RRP17 in mice results in dysmorphic LDCVs, impaired ANP secretion, and hypertension. These findings identify RRP17 as a component of the cellular machinery involved in regulated secretion within the heart and potential mediator of the endocrine influence of the heart on other tissues.<\/jats:p>","DOI":"10.1083\/jcb.200707101","type":"journal-article","created":{"date-parts":[[2007,11,5]],"date-time":"2007-11-05T21:23:35Z","timestamp":1194297815000},"page":"527-537","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["Regulation of atrial natriuretic peptide secretion by a novel Ras-like protein"],"prefix":"10.1083","volume":"179","author":[{"given":"Igor I.","family":"Rybkin","sequence":"first","affiliation":[{"name":"1Department of Molecular Biology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi-Sung","family":"Kim","sequence":"additional","affiliation":[{"name":"1Department of Molecular Biology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Bezprozvannaya","sequence":"additional","affiliation":[{"name":"1Department of Molecular Biology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Qi","sequence":"additional","affiliation":[{"name":"1Department of Molecular Biology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Richardson","sequence":"additional","affiliation":[{"name":"2Department of Pathology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig F.","family":"Plato","sequence":"additional","affiliation":[{"name":"4Gilead-Colorado, Westminster, CO 80021"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Hill","sequence":"additional","affiliation":[{"name":"3Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhonda","family":"Bassel-Duby","sequence":"additional","affiliation":[{"name":"1Department of Molecular Biology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric N.","family":"Olson","sequence":"additional","affiliation":[{"name":"1Department of Molecular Biology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2007,11,5]]},"reference":[{"key":"2023072204473219700_BIB1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0022-2828(89)90738-4","volume":"21","year":"1989","journal-title":"J. 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