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We show that tuberous sclerosis complex 1 mutations cause increased FOXO levels, resulting in elevated expression of FOXO-regulated genes, some of which are known to antagonize growth-promoting pathways. Analogous transcriptional changes are observed in mammalian cells, which implies that FOXO attenuates TOR-driven growth in diverse species.<\/jats:p>","DOI":"10.1083\/jcb.200710100","type":"journal-article","created":{"date-parts":[[2008,2,26]],"date-time":"2008-02-26T01:14:48Z","timestamp":1203988488000},"page":"691-696","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":41,"title":["FOXO-regulated transcription restricts overgrowth of <i>Tsc<\/i> mutant organs"],"prefix":"10.1083","volume":"180","author":[{"given":"Kieran F.","family":"Harvey","sequence":"first","affiliation":[{"name":"1Cell Growth and Proliferation Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia"},{"name":"2Department of Pathology, University of Melbourne, Parkville, Victoria 3010, Australia"},{"name":"5Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaakko","family":"Mattila","sequence":"additional","affiliation":[{"name":"3Institute of Biotechnology, University of Helsinki, Helsinki 00014, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avi","family":"Sofer","sequence":"additional","affiliation":[{"name":"4Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. 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