{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:08:02Z","timestamp":1790276882313,"version":"4.1.0"},"reference-count":45,"publisher":"Rockefeller University Press","issue":"2","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2008,7,28]]},"abstract":"<jats:p>OL-protocadherin (OL-pc) is a transmembrane protein belonging to the cadherin superfamily, which has been shown to accumulate at cell\u2013cell contacts via its homophilic interaction, but its molecular roles remain elusive. In this study, we show that OL-pc bound Nck-associated protein 1 (Nap1), a protein that regulates WAVE-mediated actin assembly. In astrocytoma U251 cells not expressing OL-pc, Nap1 was localized only along the lamellipodia. However, exogenous expression of OL-pc in these cells recruited Nap1 as well as WAVE1 to cell\u2013cell contact sites. Although OL-pc expression had no effect on the motility of solitary U251 cells, it accelerated their movement when they were in contact with one another, causing concomitant reorganization of F-actin and N-cadherin at cell junctions. OL-pc mutants lacking the Nap1-binding site exhibited no such effect. N-cadherin knockdown mimicked OL-pc expression in enhancing cell movement. These results suggest that OL-pc remodels the motility and adhesion machinery at cell junctions by recruiting the Nap1\u2013WAVE1 complex to these sites and, in turn, promotes the migration of cells.<\/jats:p>","DOI":"10.1083\/jcb.200802069","type":"journal-article","created":{"date-parts":[[2008,7,21]],"date-time":"2008-07-21T20:45:24Z","timestamp":1216673124000},"page":"395-410","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":109,"title":["Contact-dependent promotion of cell migration by the OL-protocadherin\u2013Nap1 interaction"],"prefix":"10.1083","volume":"182","author":[{"given":"Shinsuke","family":"Nakao","sequence":"first","affiliation":[{"name":"1Graduate School of Biostudies, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan"},{"name":"2RIKEN Center for Developmental Biology, Chuo-ku, Kobe 650-0047, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Platek","sequence":"additional","affiliation":[{"name":"2RIKEN Center for Developmental Biology, Chuo-ku, Kobe 650-0047, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Hirano","sequence":"additional","affiliation":[{"name":"2RIKEN Center for Developmental Biology, Chuo-ku, Kobe 650-0047, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Takeichi","sequence":"additional","affiliation":[{"name":"2RIKEN Center for Developmental Biology, Chuo-ku, Kobe 650-0047, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2008,7,21]]},"reference":[{"key":"2023072915020970200_BIB1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1073\/pnas.0710504105","volume":"105","year":"2008","journal-title":"Proc. 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