{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T01:55:41Z","timestamp":1792288541563,"version":"4.4.0"},"reference-count":42,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2008,11,17]]},"abstract":"<jats:p>HP1 proteins are thought to be modulators of chromatin organization in all mammals, yet their exact physiological function remains unknown. In a first attempt to elucidate the function of these proteins in vivo, we disrupted the murine Cbx1 gene, which encodes the HP1-\u03b2 isotype, and show that the Cbx1\u2212\/\u2212-null mutation leads to perinatal lethality. The newborn mice succumbed to acute respiratory failure, whose likely cause is the defective development of neuromuscular junctions within the endplate of the diaphragm. We also observe aberrant cerebral cortex development in Cbx1\u2212\/\u2212 mutant brains, which have reduced proliferation of neuronal precursors, widespread cell death, and edema. In vitro cultures of neurospheres from Cbx1\u2212\/\u2212 mutant brains reveal a dramatic genomic instability. Our results demonstrate that HP1 proteins are not functionally redundant and that they are likely to regulate lineage-specific changes in heterochromatin organization.<\/jats:p>","DOI":"10.1083\/jcb.200804041","type":"journal-article","created":{"date-parts":[[2008,11,17]],"date-time":"2008-11-17T13:39:09Z","timestamp":1226929149000},"page":"597-606","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":116,"title":["HP1-\u03b2 is required for development of the cerebral neocortex and neuromuscular junctions"],"prefix":"10.1083","volume":"183","author":[{"given":"Rebecca","family":"Aucott","sequence":"first","affiliation":[{"name":"2Division of Genetics and Genomics, Roslin Institute, University of Edinburgh, Midlothian EH25 9PS, Scotland, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u0308rn","family":"Bullwinkel","sequence":"additional","affiliation":[{"name":"1Division of Immunoepigenetics, Department 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