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In this study, we show that a lack of MCPH1 or PCNT results in a loss of Chk1 from centrosomes with subsequently deregulated activation of centrosomal cyclin B\u2013Cdk1.<\/jats:p>","DOI":"10.1083\/jcb.200810159","type":"journal-article","created":{"date-parts":[[2009,6,23]],"date-time":"2009-06-23T01:20:56Z","timestamp":1245720056000},"page":"1149-1157","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":82,"title":["Microcephalin and pericentrin regulate mitotic entry via centrosome-associated Chk1"],"prefix":"10.1083","volume":"185","author":[{"given":"Alexandra","family":"Tibelius","sequence":"first","affiliation":[{"name":"Clinical Cooperation Unit Molecular Hematology\/Oncology 1 and 2"},{"name":"Department of Tumor Virology, German Cancer Research Center, 69120 Heidelberg, Germany 1 and 2"},{"name":"Department of Internal Medicine V, University of Heidelberg, 69120 Heidelberg, Germany 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Marhold","sequence":"additional","affiliation":[{"name":"Clinical Cooperation Unit Molecular Hematology\/Oncology 1 and 2"},{"name":"Department of Tumor Virology, German Cancer Research Center, 69120 Heidelberg, Germany 1 and 2"},{"name":"Department of Internal Medicine V, University of Heidelberg, 69120 Heidelberg, Germany 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanswalter","family":"Zentgraf","sequence":"additional","affiliation":[{"name":"Clinical Cooperation Unit Molecular Hematology\/Oncology 1 and 2"},{"name":"Department of Tumor Virology, German Cancer Research Center, 69120 Heidelberg, Germany 1 and 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph E.","family":"Heilig","sequence":"additional","affiliation":[{"name":"Clinical Cooperation Unit Molecular Hematology\/Oncology 1 and 2"},{"name":"Department of Tumor Virology, German Cancer Research Center, 69120 Heidelberg, Germany 1 and 2"},{"name":"Department of Internal Medicine V, University of Heidelberg, 69120 Heidelberg, Germany 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidemarie","family":"Neitzel","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, Charit\u00e9, University of Berlin, 14195 Berlin, Germany 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Ducommun","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Cellulaire et Mol\u00e9culaire du Controle de la Prolif\u00e9ration, Centre National de la Recherche Scientifique, 31062 Toulouse, France 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Rauch","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-N\u00fcrnberg, 91054 Erlangen, Germany 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony D.","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine V, University of Heidelberg, 69120 Heidelberg, Germany 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiri","family":"Bartek","sequence":"additional","affiliation":[{"name":"Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, 2100 Copenhagen, Denmark 7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alwin","family":"Kr\u00e4mer","sequence":"additional","affiliation":[{"name":"Clinical Cooperation Unit Molecular Hematology\/Oncology 1 and 2"},{"name":"Department of Tumor Virology, German Cancer Research Center, 69120 Heidelberg, Germany 1 and 2"},{"name":"Department of Internal Medicine V, University of Heidelberg, 69120 Heidelberg, Germany 3"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2009,6,22]]},"reference":[{"key":"2023072912253847400_bib1","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1093\/hmg\/ddh335","article-title":"Seckel syndrome exhibits cellular features demonstrating defects in the ATR-signalling pathway","volume":"13","author":"Alderton","year":"2004","journal-title":"Hum. 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