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Wild-type RID-\u03b1 rescues lipid-sorting defects in cells from patients with this disease by a mechanism involving a class III phosphatidylinositol-3-kinase. In contrast to NPC disease gene products that are localized to late endosomes\/lysosomes, RID-\u03b1 induces the accumulation of autophagy-like vesicles with a unique molecular composition. Ectopic RID-\u03b1 regulates intracellular cholesterol trafficking at two distinct levels: the egress from endosomes and transport to the endoplasmic reticulum necessary for homeostatic gene regulation. However, RID-\u03b1 also induces a novel cellular phenotype, suggesting that it activates an autonomous cholesterol regulatory mechanism distinct from NPC disease gene products.<\/jats:p>","DOI":"10.1083\/jcb.200903039","type":"journal-article","created":{"date-parts":[[2009,11,16]],"date-time":"2009-11-16T22:10:13Z","timestamp":1258409413000},"page":"537-552","update-policy":"https:\/\/doi.org\/10.1083\/jcb.crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Adenovirus RID-\u03b1 activates an autonomous cholesterol regulatory mechanism that rescues defects linked to Niemann-Pick disease type C"],"prefix":"10.1083","volume":"187","author":[{"given":"Nicholas L.","family":"Cianciola","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Microbiology 1 , 2 , and 3"},{"name":"Department of Physiology and Biophysics 1 , 2 , and 3"},{"name":"Case Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, Cleveland, OH 44106 1 , 2 , and 3"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathleen R.","family":"Carlin","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Microbiology 1 , 2 , and 3"},{"name":"Department of Physiology and Biophysics 1 , 2 , and 3"},{"name":"Case Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, Cleveland, OH 44106 1 , 2 , and 3"},{"name":"Department of Molecular Biology and Microbiology 1 , 2 , and 3"},{"name":"Department of Physiology and Biophysics 1 , 2 , and 3"},{"name":"Case Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, Cleveland, OH 44106 1 , 2 , and 3"},{"name":"Department of Molecular Biology and Microbiology 1 , 2 , and 3"},{"name":"Department of Physiology and Biophysics 1 , 2 , and 3"},{"name":"Case Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, Cleveland, OH 44106 1 , 2 , and 3"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[2009,11,16]]},"reference":[{"key":"2023072912483561700_bib1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/BJ20071427","article-title":"The regulation and function of Class III PI3Ks: novel roles for Vps34","volume":"410","author":"Backer","year":"2008","journal-title":"Biochem. 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